ES2368036T3 - Composiciones de gel. - Google Patents
Composiciones de gel. Download PDFInfo
- Publication number
- ES2368036T3 ES2368036T3 ES02745605T ES02745605T ES2368036T3 ES 2368036 T3 ES2368036 T3 ES 2368036T3 ES 02745605 T ES02745605 T ES 02745605T ES 02745605 T ES02745605 T ES 02745605T ES 2368036 T3 ES2368036 T3 ES 2368036T3
- Authority
- ES
- Spain
- Prior art keywords
- gel
- glucose
- dextran
- carbomer
- con
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 239000012491 analyte Substances 0.000 claims abstract description 28
- 238000012377 drug delivery Methods 0.000 claims abstract description 7
- 229920002307 Dextran Polymers 0.000 claims description 59
- 108010062580 Concanavalin A Proteins 0.000 claims description 55
- 229940079593 drug Drugs 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 22
- 239000012528 membrane Substances 0.000 claims description 17
- 238000006116 polymerization reaction Methods 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 9
- 229920001577 copolymer Polymers 0.000 claims description 3
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims description 3
- 230000004888 barrier function Effects 0.000 claims description 2
- 230000009466 transformation Effects 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 118
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- 239000008103 glucose Substances 0.000 description 81
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 57
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 52
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- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 21
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 20
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- 238000012360 testing method Methods 0.000 description 9
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- DCUFMVPCXCSVNP-UHFFFAOYSA-N methacrylic anhydride Chemical compound CC(=C)C(=O)OC(=O)C(C)=C DCUFMVPCXCSVNP-UHFFFAOYSA-N 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
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- 108090000317 Chymotrypsin Proteins 0.000 description 3
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- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 3
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- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 2
- SXGZJKUKBWWHRA-UHFFFAOYSA-N 2-(N-morpholiniumyl)ethanesulfonate Chemical compound [O-]S(=O)(=O)CC[NH+]1CCOCC1 SXGZJKUKBWWHRA-UHFFFAOYSA-N 0.000 description 2
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
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- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
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- HBOMLICNUCNMMY-KJFJCRTCSA-N 1-[(4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1C1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-KJFJCRTCSA-N 0.000 description 1
- CSDQQAQKBAQLLE-UHFFFAOYSA-N 4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Chemical compound C1=CC(Cl)=CC=C1C1C(C=CS2)=C2CCN1 CSDQQAQKBAQLLE-UHFFFAOYSA-N 0.000 description 1
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
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- LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
- G01N33/559—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody through a gel, e.g. Ouchterlony technique
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/548—Carbohydrates, e.g. dextran
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0116860 | 2001-07-10 | ||
| GBGB0116860.8A GB0116860D0 (en) | 2001-07-10 | 2001-07-10 | Gel compositions |
Publications (1)
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|---|---|
| ES2368036T3 true ES2368036T3 (es) | 2011-11-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02745605T Expired - Lifetime ES2368036T3 (es) | 2001-07-10 | 2002-07-10 | Composiciones de gel. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8247391B2 (enExample) |
| EP (1) | EP1407267B1 (enExample) |
| JP (2) | JP2004534103A (enExample) |
| AT (1) | ATE513214T1 (enExample) |
| DK (1) | DK1407267T3 (enExample) |
| ES (1) | ES2368036T3 (enExample) |
| GB (1) | GB0116860D0 (enExample) |
| PT (1) | PT1407267E (enExample) |
| WO (1) | WO2003006993A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0116860D0 (en) | 2001-07-10 | 2001-09-05 | Univ Montfort | Gel compositions |
| DE10254636A1 (de) * | 2002-11-22 | 2004-06-09 | Capsulution Nanoscience Ag | Verfahren zum Modifizieren von Mikropartikeln sowie Vorrichtung zum Modifizieren von Mikropartikeln |
| CA3066594A1 (en) * | 2004-10-08 | 2006-04-20 | Georgia Tech Research Corporation | Microencapsulation of cells in hydrogels using electrostatic potentials |
| CN102325814B (zh) * | 2009-01-14 | 2014-03-12 | 康奈尔大学 | 用于生物医学用途的生物可降解型水凝胶的制备 |
| CN101745114B (zh) * | 2009-12-25 | 2013-01-23 | 浙江工业大学 | 一种对葡萄糖敏感可自控释胰岛素的生物材料的制备方法 |
| US20140350370A1 (en) * | 2013-04-08 | 2014-11-27 | The Texas A&M University System | Glucose sensing assay |
| GB201310185D0 (en) | 2013-06-07 | 2013-07-24 | Univ Montfort | Container |
| GB201314640D0 (en) * | 2013-08-15 | 2013-10-02 | Univ Montfort | Matrix gel |
| CN113350489A (zh) | 2015-04-21 | 2021-09-07 | 北卡罗来纳州立大学 | 使用缺氧敏感性纳米复合材料的葡萄糖响应性胰岛素递送系统 |
| CN108366960B (zh) * | 2015-10-23 | 2022-04-19 | 国立大学法人东京医科齿科大学 | 药物递送装置 |
| WO2018085809A1 (en) | 2016-11-07 | 2018-05-11 | North Carolina State University | Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery |
| NO343313B1 (en) * | 2017-03-15 | 2019-01-28 | Lifecare As | Fluid composition, method for preparing the composition and use |
| BR112021011103A8 (pt) * | 2018-12-18 | 2022-08-09 | Currahee Holding Company Inc | Emplastro personalizado para aplicação tópica |
| US20220370493A1 (en) * | 2019-06-04 | 2022-11-24 | Thirty Holdings Limited | Methods and compositions for generating nitric oxide and uses thereof |
| AU2020286987B2 (en) * | 2019-06-04 | 2025-09-11 | Thirty Respiratory Limited | Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract |
| TWI899548B (zh) * | 2023-03-13 | 2025-10-01 | 羅怡情 | 染髮用凝膠的用途及製法 |
| CN121243060B (zh) * | 2025-11-07 | 2026-08-11 | 江苏知原药业股份有限公司 | 一种高稳定性的阿达帕林凝胶的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705503A (en) * | 1986-02-03 | 1987-11-10 | Regents Of The University Of Minnesota | Metabolite sensor including a chemical concentration sensitive flow controller for a drug delivery system |
| GB9200638D0 (en) | 1992-01-10 | 1992-03-11 | Leicester Polytechnic | Drug system |
| DE4203466A1 (de) | 1992-02-04 | 1993-08-05 | Rudolf Prof Dr Ehwald | Affinitaets-sensor |
| GB9313484D0 (en) * | 1993-06-30 | 1993-08-11 | Univ Montfort | Drug system ii |
| US5562917A (en) * | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
| JP3536186B2 (ja) * | 1995-02-27 | 2004-06-07 | 独立行政法人 科学技術振興機構 | 生体内分解性高分子ヒドロゲル |
| US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| WO1998022097A2 (en) * | 1996-11-20 | 1998-05-28 | Bio Advances, Llc | Controlled release matrix composition using polar polymer or monomer and poly(acrylic acid) blend |
| GB9805896D0 (en) | 1998-03-20 | 1998-05-13 | Eglise David | Remote analysis system |
| CA2337667C (en) | 1998-08-10 | 2008-04-29 | Amgen Inc. | Dextran-leptin conjugates, pharmaceutical compositions and related methods |
| AU6931500A (en) | 1999-08-27 | 2001-03-26 | M-Biotech, Inc. | Glucose biosensor |
| GB0116860D0 (en) | 2001-07-10 | 2001-09-05 | Univ Montfort | Gel compositions |
-
2001
- 2001-07-10 GB GBGB0116860.8A patent/GB0116860D0/en not_active Ceased
-
2002
- 2002-07-10 JP JP2003512710A patent/JP2004534103A/ja not_active Withdrawn
- 2002-07-10 EP EP02745605A patent/EP1407267B1/en not_active Expired - Lifetime
- 2002-07-10 AT AT02745605T patent/ATE513214T1/de active
- 2002-07-10 ES ES02745605T patent/ES2368036T3/es not_active Expired - Lifetime
- 2002-07-10 PT PT02745605T patent/PT1407267E/pt unknown
- 2002-07-10 WO PCT/GB2002/003183 patent/WO2003006993A2/en not_active Ceased
- 2002-07-10 US US10/483,313 patent/US8247391B2/en not_active Expired - Fee Related
- 2002-07-10 DK DK02745605.2T patent/DK1407267T3/da active
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2011
- 2011-03-16 JP JP2011058397A patent/JP5405511B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB0116860D0 (en) | 2001-09-05 |
| ATE513214T1 (de) | 2011-07-15 |
| PT1407267E (pt) | 2011-09-19 |
| EP1407267A2 (en) | 2004-04-14 |
| WO2003006993A2 (en) | 2003-01-23 |
| JP2004534103A (ja) | 2004-11-11 |
| US8247391B2 (en) | 2012-08-21 |
| US20040265386A1 (en) | 2004-12-30 |
| WO2003006993A3 (en) | 2003-09-25 |
| JP5405511B2 (ja) | 2014-02-05 |
| EP1407267B1 (en) | 2011-06-15 |
| JP2011144197A (ja) | 2011-07-28 |
| DK1407267T3 (da) | 2011-09-19 |
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