ES2336873B1 - Composicion farmaceutica para el tratamiento de cancer. - Google Patents

Composicion farmaceutica para el tratamiento de cancer. Download PDF

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Publication number
ES2336873B1
ES2336873B1 ES200702961A ES200702961A ES2336873B1 ES 2336873 B1 ES2336873 B1 ES 2336873B1 ES 200702961 A ES200702961 A ES 200702961A ES 200702961 A ES200702961 A ES 200702961A ES 2336873 B1 ES2336873 B1 ES 2336873B1
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ES
Spain
Prior art keywords
interferon
ifn
cancer
receptor
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn - After Issue
Application number
ES200702961A
Other languages
English (en)
Spanish (es)
Other versions
ES2336873A1 (es
Inventor
Sandra Hervas Stubbs
Juan Dubrot Armendariz
Ignacio Javier Melero Bermejo
Agnes Laurence Le Bon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proyecto de Biomedicina CIMA SL
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Proyecto de Biomedicina CIMA SL
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200702961A priority Critical patent/ES2336873B1/es
Application filed by Proyecto de Biomedicina CIMA SL, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Proyecto de Biomedicina CIMA SL
Priority to CN2008801242034A priority patent/CN101951955A/zh
Priority to JP2010532625A priority patent/JP2011503039A/ja
Priority to BRPI0820351A priority patent/BRPI0820351A2/pt
Priority to PCT/ES2008/000693 priority patent/WO2009060112A1/es
Priority to RU2010122934/15A priority patent/RU2010122934A/ru
Priority to EP08846883A priority patent/EP2223701A1/en
Priority to AU2008324056A priority patent/AU2008324056A1/en
Priority to US12/741,304 priority patent/US20110059045A1/en
Priority to CA2705105A priority patent/CA2705105A1/en
Priority to MX2010005086A priority patent/MX2010005086A/es
Publication of ES2336873A1 publication Critical patent/ES2336873A1/es
Application granted granted Critical
Publication of ES2336873B1 publication Critical patent/ES2336873B1/es
Withdrawn - After Issue legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7156—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES200702961A 2007-11-07 2007-11-07 Composicion farmaceutica para el tratamiento de cancer. Withdrawn - After Issue ES2336873B1 (es)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ES200702961A ES2336873B1 (es) 2007-11-07 2007-11-07 Composicion farmaceutica para el tratamiento de cancer.
US12/741,304 US20110059045A1 (en) 2007-11-07 2008-11-07 Pharmaceutical composition for cancer treatment
BRPI0820351A BRPI0820351A2 (pt) 2007-11-07 2008-11-07 composição de pelo um ligante agonista receptor de 4-1bb, seu uso, preparado farmacêutico que a compreende, kit de um ou vários recipientes, usos desse kit, uso de um interferon do tipo i´, polinucleotídeo, vetor, célula e usos de um polinucleotídeo
PCT/ES2008/000693 WO2009060112A1 (es) 2007-11-07 2008-11-07 Composición farmacéutica para el tratamiento de cáncer
RU2010122934/15A RU2010122934A (ru) 2007-11-07 2008-11-07 Фармацевтическая композиция для лечения злокачественных опухолей
EP08846883A EP2223701A1 (en) 2007-11-07 2008-11-07 Pharmaceutical composition for cancer treatment
CN2008801242034A CN101951955A (zh) 2007-11-07 2008-11-07 用于治疗癌症的药物组合物
JP2010532625A JP2011503039A (ja) 2007-11-07 2008-11-07 癌治療用医薬組成物
CA2705105A CA2705105A1 (en) 2007-11-07 2008-11-07 Pharmaceutical composition for cancer treatment
MX2010005086A MX2010005086A (es) 2007-11-07 2008-11-07 Composicion farmaceutica para el tratamiento de cancer.
AU2008324056A AU2008324056A1 (en) 2007-11-07 2008-11-07 Pharmaceutical composition for cancer treatment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200702961A ES2336873B1 (es) 2007-11-07 2007-11-07 Composicion farmaceutica para el tratamiento de cancer.

Publications (2)

Publication Number Publication Date
ES2336873A1 ES2336873A1 (es) 2010-04-16
ES2336873B1 true ES2336873B1 (es) 2011-01-24

Family

ID=40351964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200702961A Withdrawn - After Issue ES2336873B1 (es) 2007-11-07 2007-11-07 Composicion farmaceutica para el tratamiento de cancer.

Country Status (11)

Country Link
US (1) US20110059045A1 (enExample)
EP (1) EP2223701A1 (enExample)
JP (1) JP2011503039A (enExample)
CN (1) CN101951955A (enExample)
AU (1) AU2008324056A1 (enExample)
BR (1) BRPI0820351A2 (enExample)
CA (1) CA2705105A1 (enExample)
ES (1) ES2336873B1 (enExample)
MX (1) MX2010005086A (enExample)
RU (1) RU2010122934A (enExample)
WO (1) WO2009060112A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103611163A (zh) * 2011-09-05 2014-03-05 韩美科学株式会社 一种包含干扰素α-缀合物的抗癌用药物组合物
CA2879066C (en) 2012-07-13 2019-08-13 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
TWI718086B (zh) * 2013-01-07 2021-02-11 英屬維爾京群島商遠東超級實驗室有限公司 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物
US20170000850A1 (en) * 2013-12-20 2017-01-05 National University Of Singapore Differentiation therapy with cd137 ligand agonists
WO2016156291A1 (en) 2015-03-31 2016-10-06 F. Hoffmann-La Roche Ag Antigen binding molecules comprising a trimeric tnf family ligand
WO2019036855A1 (en) 2017-08-21 2019-02-28 Adagene Inc. Anti-cd137 molecules and use thereof
WO2019104716A1 (en) * 2017-12-01 2019-06-06 Adagene Inc. Methods for using cd137 ligand as biomarker for treatment with anti-cd137 antibody
WO2019148445A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Precision/context-dependent activatable antibodies, and methods of making and using the same
WO2019148444A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Anti-ctla4 antibodies and methods of making and using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007048077A2 (en) * 2005-10-21 2007-04-26 Gtc Biotherapeutics, Inc. Antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040197312A1 (en) * 2003-04-02 2004-10-07 Marina Moskalenko Cytokine-expressing cellular vaccine combinations
EP1851244A4 (en) * 2005-02-15 2009-04-15 Gtc Biotherapeutics Inc ANTI-CD137 ANTIBODY AS A MEANS FOR THE TREATMENT OF CANCER, AND GLYCOSYLATION VARIANTS THEREOF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007048077A2 (en) * 2005-10-21 2007-04-26 Gtc Biotherapeutics, Inc. Antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JU SEONG-A et al. "{}Immunity to melanoma mediated by 4-1BB is associated with enhanced activity of tumour-infiltrating lymphocytes."{} Immunology and Cell Biology (2005) Vol. 83, páginas 344-351. Páginas 344,347-351. *
LE BON AGNES et al. "{}Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN."{} Journal of immunology (2006) Vol. 176, no. 4, páginas 2074-2078. Páginas 2074-2075. *
LE BON AGNES et al. "{}Direct stimulation of T cells by type I IFN enhances the CD8(+) T cell response during cross-priming."{} Journal of immunology (2006) Vol. 176, no. 8, páginas 4682-4689. Páginas 4682-4684,4687-4688. *

Also Published As

Publication number Publication date
CN101951955A (zh) 2011-01-19
MX2010005086A (es) 2010-08-10
CA2705105A1 (en) 2009-05-14
EP2223701A1 (en) 2010-09-01
WO2009060112A1 (es) 2009-05-14
ES2336873A1 (es) 2010-04-16
US20110059045A1 (en) 2011-03-10
RU2010122934A (ru) 2011-12-20
AU2008324056A1 (en) 2009-05-14
BRPI0820351A2 (pt) 2015-10-27
JP2011503039A (ja) 2011-01-27

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