ES233176A1 - A procedure for the preparation of amidas of alpha-N-alkyl-piperidin and alpha-N-alkyl-pyrrolidine carboxylic acid (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of amidas of alpha-N-alkyl-piperidin and alpha-N-alkyl-pyrrolidine carboxylic acid (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES233176A1 ES233176A1 ES0233176A ES233176A ES233176A1 ES 233176 A1 ES233176 A1 ES 233176A1 ES 0233176 A ES0233176 A ES 0233176A ES 233176 A ES233176 A ES 233176A ES 233176 A1 ES233176 A1 ES 233176A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- carboxylic acid
- alpha
- piperidin
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 241000670727 Amida Species 0.000 title 1
- 150000001408 amides Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- -1 polymethylene Polymers 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pyrrole Compounds (AREA)
Abstract
A process for the preparation of amides of α-N-alkyl-piperidin and α-N-alkyl-pyrrolidine carboxylic acid according to the formulas: ** (See formula) ** wherein R designates an alkyl group and Ar a 2-alkylbenzene or 2,6-dialkylbenzene group, characterized in that an arylamide ester of maleic acid, of the general formula: ** (See formula) ** wherein R1 designates alkyl and Ar has the same meaning as above, it is nitrated, reduced and linked with a polymethylene dihalogenide, whereby a product of the general formula is obtained: ** (See formula) ** where n indicates 3 or 4, whose product by treatment with mineral acids is brought to close the ring and is decarboxylated with the formation of 2-piperidinecarboxylic acid and amide of α -pyrrole carboxylic acid respectively, which by alkalization of ring nitrogen give rise to the amides of α -N-alkyl-piperidine carboxylic acid and αN-alkyl-pyrrolidine carboxylic acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE60756 | 1956-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES233176A1 true ES233176A1 (en) | 1957-07-01 |
Family
ID=38526806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0233176A Expired ES233176A1 (en) | 1956-01-23 | 1957-01-17 | A procedure for the preparation of amidas of alpha-N-alkyl-piperidin and alpha-N-alkyl-pyrrolidine carboxylic acid (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES233176A1 (en) |
-
1957
- 1957-01-17 ES ES0233176A patent/ES233176A1/en not_active Expired
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