ES2323813T3 - Alteraciones especificas de la enfermedad de alzheimer de la proporcion de fosforilacion erk1/erk2 - biomarcadores moleculares especificos de la enfermedad de alzheimer (adsmb). - Google Patents
Alteraciones especificas de la enfermedad de alzheimer de la proporcion de fosforilacion erk1/erk2 - biomarcadores moleculares especificos de la enfermedad de alzheimer (adsmb). Download PDFInfo
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- ES2323813T3 ES2323813T3 ES06825096T ES06825096T ES2323813T3 ES 2323813 T3 ES2323813 T3 ES 2323813T3 ES 06825096 T ES06825096 T ES 06825096T ES 06825096 T ES06825096 T ES 06825096T ES 2323813 T3 ES2323813 T3 ES 2323813T3
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- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
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- Toxicology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Hospice & Palliative Care (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US246524 | 1994-05-20 | ||
| WOUS2005/036014 | 2005-10-11 | ||
| US11/246,524 US7595167B2 (en) | 2005-10-11 | 2005-10-11 | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio |
| PCT/US2005/036014 WO2007043998A1 (en) | 2005-10-11 | 2005-10-11 | Alzheimer’s disease-specific alterations of the erk1/erk2 phosphorylation ratio |
| WOUS2006/022156 | 2006-06-07 | ||
| PCT/US2006/022156 WO2007044094A1 (en) | 2005-10-11 | 2006-06-07 | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
Publications (1)
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| ES2323813T3 true ES2323813T3 (es) | 2009-07-24 |
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| ES08020258T Active ES2412268T3 (es) | 2005-10-11 | 2006-09-25 | Alteraciones específicas de la Enfermedad de Alzheimer de la relación de fosforilación ERK1/ERK2 como biomarcadores moleculares específicos de la Enfermedad de Alzheimer (ADSMB) |
| ES10012836.2T Active ES2477284T3 (es) | 2005-10-11 | 2006-09-25 | Método de monitorización de la progresión de la enfermedad de Alzheimer por medición de un biomarcador |
| ES10011288.7T Active ES2588376T3 (es) | 2005-10-11 | 2006-09-25 | Procedimientos para la identificación de tratamientos de la enfermedad de Alzheimer |
| ES10011289.5T Active ES2596881T3 (es) | 2005-10-11 | 2006-09-25 | Kit para el diagnóstico de la Enfermedad de Alzheimer |
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| Application Number | Title | Priority Date | Filing Date |
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| ES08020258T Active ES2412268T3 (es) | 2005-10-11 | 2006-09-25 | Alteraciones específicas de la Enfermedad de Alzheimer de la relación de fosforilación ERK1/ERK2 como biomarcadores moleculares específicos de la Enfermedad de Alzheimer (ADSMB) |
| ES10012836.2T Active ES2477284T3 (es) | 2005-10-11 | 2006-09-25 | Método de monitorización de la progresión de la enfermedad de Alzheimer por medición de un biomarcador |
| ES10011288.7T Active ES2588376T3 (es) | 2005-10-11 | 2006-09-25 | Procedimientos para la identificación de tratamientos de la enfermedad de Alzheimer |
| ES10011289.5T Active ES2596881T3 (es) | 2005-10-11 | 2006-09-25 | Kit para el diagnóstico de la Enfermedad de Alzheimer |
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| Country | Link |
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| US (1) | US20180024146A1 (https=) |
| EP (5) | EP2322936A1 (https=) |
| JP (1) | JP4908514B2 (https=) |
| KR (2) | KR20140002073A (https=) |
| AT (1) | ATE431558T1 (https=) |
| CA (1) | CA2625300C (https=) |
| DE (1) | DE602006006855D1 (https=) |
| ES (5) | ES2323813T3 (https=) |
| TW (2) | TW201413246A (https=) |
| WO (1) | WO2007044094A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2002254029A1 (en) | 2001-02-27 | 2002-09-12 | Daniel L. Alkon | Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation |
| US20050065205A1 (en) | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
| US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| TW201206425A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
| US7595167B2 (en) | 2005-10-11 | 2009-09-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio |
| US20090029873A1 (en) | 2005-10-11 | 2009-01-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb) |
| US20080025961A1 (en) * | 2006-07-28 | 2008-01-31 | Alkon Daniel L | Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory |
| EP3332797A3 (en) | 2007-02-09 | 2018-08-01 | Blanchette Rockefeller Neurosciences Institute | Therapeutic effects of bryostatins, bryologs and other related substances on head trauma-induced memory impairment and brain injury |
| EP2669386A1 (en) | 2008-07-28 | 2013-12-04 | Blanchette Rockefeller Neurosciences Institute | Stimulus-elicited genomic profile markers of alzheimer's disease |
| CA2731171C (en) | 2008-07-28 | 2016-10-18 | Blanchette Rockefeller Neurosciences Institute | Pkc-activating compounds for the treatment of neurodegenerative diseases |
| BRPI0914859A2 (pt) * | 2008-08-27 | 2015-11-03 | Lundbeck & Co As H | método para diagnosticar um distúrbio afetivo, produto de programa de computador, computador, e, método para determinar uma probabilidade de que um indivíduo de teste exiba um sintoma de um distúrbio afetivo |
| EP2483695A2 (en) * | 2009-10-02 | 2012-08-08 | Blanchette Rockefeller Neurosciences, Institute | Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells |
| EP2483684B1 (en) * | 2009-10-02 | 2018-04-18 | Blanchette Rockefeller Neurosciences, Institute | Fibroblast growth patterns to diagnose alzheimer's disease |
| EP2707693B1 (en) * | 2011-05-12 | 2016-10-12 | Florin V. Chirila | Peripheral diagnostic methods for screening alzheimer's disease using beta amyloid and intercellular communication |
| EP2780316B1 (en) | 2011-11-13 | 2020-04-15 | Blanchette Rockefeller Neurosciences Institute | Esters of dcpla and methods of treatment using the same |
| KR101351978B1 (ko) * | 2012-10-30 | 2014-01-16 | 주식회사 코씨드바이오팜 | 참치 안구 파쇄물을 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물 및 식품 조성물 |
| US20170023552A1 (en) * | 2014-01-03 | 2017-01-26 | Blanchette Rockefeller Neurosciences Institute | Convergence of aggregation rate with validated peripheral diagnostic for alzheimer's disease |
| EP3600027B1 (en) | 2017-03-31 | 2026-02-18 | Neurodiagnostics LLC | Lymphocyte-based morphometric test for alzheimer's disease |
| CA3141059A1 (en) * | 2019-05-23 | 2020-11-26 | Indiana University Research And Technology Corporation | Methods for objective assessment of memory, early detection of risk for alzheimer's disease, matching individuals with treatments, monitoring response to treatment, and new methods of use for drugs |
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| JP4374316B2 (ja) * | 1993-01-25 | 2009-12-02 | 武田薬品工業株式会社 | β−アミロイドまたはその誘導体に対する抗体およびその用途 |
| US6107050A (en) | 1993-05-03 | 2000-08-22 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic test for alzheimers disease |
| US20030108956A1 (en) * | 1993-05-03 | 2003-06-12 | Alkon Daniel L. | Cell tests for Alzheimer's disease |
| US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| US20030165481A1 (en) * | 2000-02-24 | 2003-09-04 | Hersh Louis B. | Amyloid peptide inactivating enzyme to treat Alzheimer's disease |
| AU2002254029A1 (en) | 2001-02-27 | 2002-09-12 | Daniel L. Alkon | Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation |
| US6825229B2 (en) * | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| KR100574017B1 (ko) | 2003-08-11 | 2006-04-26 | 삼성전자주식회사 | 잉크젯 프린터의 잉크 카트리지 |
| US7199386B2 (en) | 2004-07-29 | 2007-04-03 | General Electric Company | System and method for detecting defects in a light-management film |
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2006
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- 2006-09-25 EP EP10011290A patent/EP2322936A1/en not_active Withdrawn
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- 2006-09-25 KR KR1020137031223A patent/KR20140002073A/ko not_active Withdrawn
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2008
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2017
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2588376T3 (es) | 2016-11-02 |
| ES2477284T3 (es) | 2014-07-16 |
| JP4908514B2 (ja) | 2012-04-04 |
| EP2322934B1 (en) | 2016-08-31 |
| EP2031398B1 (en) | 2013-02-13 |
| EP2031398A1 (en) | 2009-03-04 |
| CA2625300A1 (en) | 2007-04-26 |
| TWI448688B (zh) | 2014-08-11 |
| EP2322936A1 (en) | 2011-05-18 |
| EP2317321A1 (en) | 2011-05-04 |
| JP2009511905A (ja) | 2009-03-19 |
| TW201413246A (zh) | 2014-04-01 |
| EP2339349A1 (en) | 2011-06-29 |
| TW200801515A (en) | 2008-01-01 |
| ES2596881T3 (es) | 2017-01-12 |
| ES2412268T3 (es) | 2013-07-10 |
| US20180024146A1 (en) | 2018-01-25 |
| ATE431558T1 (de) | 2009-05-15 |
| EP2317321B1 (en) | 2014-04-02 |
| EP2339349B1 (en) | 2016-08-17 |
| DE602006006855D1 (de) | 2009-06-25 |
| WO2007044094A1 (en) | 2007-04-19 |
| EP2322934A1 (en) | 2011-05-18 |
| KR20140002073A (ko) | 2014-01-07 |
| CA2625300C (en) | 2018-01-02 |
| KR101375552B1 (ko) | 2014-03-24 |
| KR20080066785A (ko) | 2008-07-16 |
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