ES2307511T3 - Derivados de eritromicina c-2 modificados. - Google Patents
Derivados de eritromicina c-2 modificados. Download PDFInfo
- Publication number
- ES2307511T3 ES2307511T3 ES00930370T ES00930370T ES2307511T3 ES 2307511 T3 ES2307511 T3 ES 2307511T3 ES 00930370 T ES00930370 T ES 00930370T ES 00930370 T ES00930370 T ES 00930370T ES 2307511 T3 ES2307511 T3 ES 2307511T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- formula
- modified
- bacterial infections
- erythromycin derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
A compuesto seleccionado del grupo que consiste en un compuesto de fórmula (I) (Ver fórmula) un compuesto de fórmula (II) (Ver fórmula) y un compuesto de fórmula (III) (Ver fórmula) y sus sales, ésteres, y profármacos farmacéuticamente aceptables, donde, en las fórmulas (I)-(III), Y y Z se seleccionan juntos del grupo que consiste en (1) oxo, (2) =N-OH, (3) =N-OR 1 donde R 1 se selecciona del grupo que consiste en (a) -alquilo C1-C12, (b) -alquilo C1-C12 sustituido con arilo, (c) -alquilo C1-C12 sustituido con arilo sustituido, (d) -alquilo C1-C12 sustituido con heteroarilo...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US312517 | 1989-02-21 | ||
US09/312,517 US6355620B1 (en) | 1999-05-14 | 1999-05-14 | C-2 modified erythromycin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2307511T3 true ES2307511T3 (es) | 2008-12-01 |
Family
ID=23211820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00930370T Expired - Lifetime ES2307511T3 (es) | 1999-05-14 | 2000-05-04 | Derivados de eritromicina c-2 modificados. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6355620B1 (es) |
EP (1) | EP1181299B1 (es) |
JP (1) | JP2002544284A (es) |
AT (1) | ATE398627T1 (es) |
CA (1) | CA2372270C (es) |
DE (1) | DE60039238D1 (es) |
DK (1) | DK1181299T3 (es) |
ES (1) | ES2307511T3 (es) |
MX (1) | MXPA01011633A (es) |
PT (1) | PT1181299E (es) |
WO (1) | WO2000069875A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0105190A3 (en) | 1999-01-27 | 2003-03-28 | Pfizer Prod Inc | Ketolide antibiotics, medicaments containing them and their use |
JP2003500414A (ja) * | 1999-05-24 | 2003-01-07 | ファイザー・プロダクツ・インク | 13−メチルエリスロマイシン誘導体 |
EP1167376B1 (en) * | 2000-06-30 | 2004-07-14 | Pfizer Products Inc. | Macrolide antibiotics |
ATE345350T1 (de) * | 2000-12-21 | 2006-12-15 | Glaxo Group Ltd | Makrolidantibiotika |
DE10122139A1 (de) * | 2001-05-08 | 2002-11-21 | Daniel Swarovski | Verfahren und Vorrichtung zur Bestimmung der Verteilung von Inhaltsstoffen in fluiden Medien |
HUP0500018A3 (en) | 2001-12-05 | 2009-09-28 | Ortho Mcneil Pharm Inc | 6-o-acyl ketolide derivatives of erythromycine processes for preparing them and using them as antibacterials |
US7273853B2 (en) * | 2002-05-13 | 2007-09-25 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic ketolide derivatives |
US7910558B2 (en) * | 2002-05-13 | 2011-03-22 | Enanta Pharmaceuticals, Inc. | Bridged macrocyclic compounds and processes for the preparation thereof |
US6841664B2 (en) * | 2002-07-25 | 2005-01-11 | Enanra Pharmaceuticals, Inc. | 6,11-4-carbon bridged ketolides |
EP1618120A2 (en) | 2003-04-25 | 2006-01-25 | Chiron Corporation | Novel ketolide derivatives |
US7414030B2 (en) * | 2004-01-07 | 2008-08-19 | Enanta Pharmaceuticals, Inc. | 6-11 Bicyclic erythromycin derivatives |
WO2005070113A2 (en) * | 2004-01-09 | 2005-08-04 | Enanta Pharmaceuticals, Inc. | 9n-substituted 6-11 bicyclic erythromycin derivatives |
US7384921B2 (en) * | 2004-02-20 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | Polymorphic forms of 6-11 bicyclic ketolide derivatives |
US20050250713A1 (en) * | 2004-04-26 | 2005-11-10 | Bin Zhu | 11,12-Cyclic thiocarbamate macrolide antibacterial agents |
WO2006065743A2 (en) * | 2004-12-13 | 2006-06-22 | Enanta Pharmaceuticals, Inc. | Tetracylic bicyclolides |
EP2233493A1 (en) * | 2004-12-21 | 2010-09-29 | Pfizer Products Inc. | Macrolides |
US7384922B2 (en) * | 2005-05-04 | 2008-06-10 | Enanta Pharmaceuticals, Inc. | 6-11 bridged oxime erythromycin derivatives |
US20060252710A1 (en) * | 2005-05-04 | 2006-11-09 | Guoqiang Wang | 6-11 Bridged oxime erythromycin derivatives |
US8293715B2 (en) | 2007-08-06 | 2012-10-23 | Taisho Pharmaceutical Co., Ltd. | 10a-Azalide compound crosslinked at 10a- and 12-positions |
US8273720B2 (en) * | 2007-09-17 | 2012-09-25 | Enanta Pharmaceuticals, Inc. | 6,11-bicyclolides: bridged biaryl macrolide derivatives |
US8354383B2 (en) * | 2007-09-17 | 2013-01-15 | Enanta Pharmaceuticals, Inc. | 6,11-bridged biaryl macrolides |
CA2699733C (en) * | 2007-09-17 | 2013-01-22 | Enanta Pharmaceuticals, Inc. | 6,11-bridged biaryl macrolides |
TW200946109A (en) * | 2008-05-09 | 2009-11-16 | Enanta Pharm Inc | Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides |
US8299035B2 (en) | 2008-05-15 | 2012-10-30 | Taisho Pharmaceutucal Co., Ltd. | 10a-azalide compound having 4-membered ring structure |
CN104650166B (zh) * | 2014-11-17 | 2017-12-05 | 广东东阳光药业有限公司 | 一种大环内酯的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL114589A (en) * | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of the history of erythromycin |
DE69127457T2 (de) | 1990-11-28 | 1998-01-22 | Taisho Pharmaceutical Co., Ltd., Tokio/Tokyo | 6-0-methylerythromycin a-derivat |
US5591837A (en) | 1992-04-22 | 1997-01-07 | Taisho Pharmaceutical Co., Ltd. | 5-O-desosaminylerythronolide a derivative |
FR2742757B1 (fr) | 1995-12-22 | 1998-01-30 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
US5940488A (en) * | 1996-11-15 | 1999-08-17 | Active Voice Corporation | Telecommunication management system and user interface |
DK1025114T3 (da) * | 1997-09-30 | 2004-07-05 | Abbott Lab | 3'-N-modificerede 6-O-substituerede erythromycin-ketolidderivater med antibakteriel aktivitet |
-
1999
- 1999-05-14 US US09/312,517 patent/US6355620B1/en not_active Expired - Lifetime
-
2000
- 2000-05-04 PT PT00930370T patent/PT1181299E/pt unknown
- 2000-05-04 DK DK00930370T patent/DK1181299T3/da active
- 2000-05-04 CA CA002372270A patent/CA2372270C/en not_active Expired - Fee Related
- 2000-05-04 WO PCT/US2000/012202 patent/WO2000069875A1/en active Application Filing
- 2000-05-04 ES ES00930370T patent/ES2307511T3/es not_active Expired - Lifetime
- 2000-05-04 EP EP00930370A patent/EP1181299B1/en not_active Expired - Lifetime
- 2000-05-04 MX MXPA01011633A patent/MXPA01011633A/es active IP Right Grant
- 2000-05-04 JP JP2000618291A patent/JP2002544284A/ja active Pending
- 2000-05-04 AT AT00930370T patent/ATE398627T1/de not_active IP Right Cessation
- 2000-05-04 DE DE60039238T patent/DE60039238D1/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2372270C (en) | 2008-07-22 |
US6355620B1 (en) | 2002-03-12 |
CA2372270A1 (en) | 2000-11-23 |
PT1181299E (pt) | 2008-09-18 |
EP1181299A1 (en) | 2002-02-27 |
DE60039238D1 (de) | 2008-07-31 |
WO2000069875A9 (en) | 2002-02-21 |
ATE398627T1 (de) | 2008-07-15 |
MXPA01011633A (es) | 2002-07-30 |
DK1181299T3 (da) | 2008-10-27 |
JP2002544284A (ja) | 2002-12-24 |
WO2000069875A1 (en) | 2000-11-23 |
EP1181299B1 (en) | 2008-06-18 |
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