ES2275466T3 - CLOSURE OF PLASTIC FOR ROADS AND OTHER MEDICAL CONTAINERS. - Google Patents

Abstract

The plastic closure of this invention is particularly, but not exclusively adapted for sealing pharmaceutical substances within prefilled cartridges and other medical containers or as a collar for retaining a fluid transferset on a medical container. The plastic closure of this invention includes a generally tubular portion which surrounds the rim of the container and a free end portion which is permanently radially deformed or crimped toward the neck of the container. The plastic closure of this invention is formed of a polymer, preferably a polymeric alloy or melt blend, which is sufficiently malleable to permit radial deformation, yet sufficiently rigid to retain its shape following deformation and sufficiently resistant to creep to maintain the seal between the plastic closure and the container following deformation. <IMAGE>

Description

Plastic closure for vials and others medical containers

Field of the invention

The invention relates to a plastic closure improved such as a capsule or cap or collar to close simply or hermetically close containers such as vials that contain a medication that eliminates the associated problems with a malleable metal capsule or collar such as aluminum. The plastic closure of this invention can be used as a capsule to tightly close a traditional vial that has a plug or cap of elastomer or a collar to retain a fluid transfer assembly separated from the collar or from a piece with him.

Background of the invention

It is usual to store such pharmaceutical products as substances of drugs or vaccines in a vial or other container Hermetically sealed for later use. Such substances they can be in dry form or powder to increase their own life and reduce inventory space. Such dry substances or in powder are usually stored in a closed vial hermetically and then reconstituted in liquid form for administration to a patient by adding a diluent or solvent. Alternatively, the substance may be in liquid form or Even soda.

A traditional vial to store a substance pharmaceutical generally includes an open end, a part of radial edge surrounding the open end and a collar part of reduced diameter adjacent to the edge part. The vial is hermetically sealed with a shutter of elastomer that generally includes a tubular part inserted in the vial collar and a flat-edged part that covers the vial edge The shutter is normally secured to the vial with a thin malleable metal capsule or cap, such as from aluminum. The aluminum capsule includes a tubular part that surrounds the edge portions of the shutter and vial, an annular part that protrudes inwardly covering the edge portion of the shutter and a distal end part that is bent inward or radially deformed in the vial collar below the edge of the vial Because aluminum is malleable, the collar accommodates the existence of dimensions tolerances of the shutter and the edge of the vial. The dimensions and tolerances of standard vials and shutters are set by the Organization of International Standardization (ISO).

The radial part of the aluminum capsule that covers the edge part of the shutter may be closed, in in which case the aluminum capsule is removed "by taking off or pulling of "the aluminum capsule of the vial. An appendix is provided pre-cut located in the middle area that covers the edge of the vial, allowing the capsule to be separated by breaking the part upper and detached from the vial before use. This realization Closed aluminum capsule has several disadvantages. In First, the breakage of the metal capsule creates sharp edges that can cut or damage sterile gloves and cut the person that administers the drug, exposing therefore both the worker health as the patient to damage and contamination of the drug. In second, the breakage of the aluminum capsule generates particles Metals that can also contaminate the drug. The dangers associated with the breakage of an aluminum capsule have been partially solved by adding a plastic capsule "superimposed." In such an embodiment, the aluminum collar includes a central opening and a shallow cup-shaped capsule plastic is received on the aluminum collar that has a central protruding riveting part that is received and secured in the central opening of the aluminum collar. The capsule of plastic is then removed forcing the capsule superimposed away from the aluminum collar, which breaks or tears an annular toothed part that surrounds the central opening and exposes a opening in the collar for the reception of a hypodermic needle or Similary. This embodiment reduces but does not eliminate the possibility of break or tear the sterile gloves of the healthcare worker. More important, however, aluminum powder is still created what It can contaminate the medicine. It is also important to observe that metallic dust is also created simply by forming and fixing the aluminum collar to the vial since the aluminum powder It is created by forming the aluminum collar, the highlight of the collar and the removal of the plastic capsule superimposed. Aluminum collars have also been used to ensure a fluid transfer assembly in vials. The sets of transfer can be used, for example, to transfer fluid from a syringe to a vial, such as to reconstitute a dry or powdered substance in a vial by adding a diluent or solvent The reconstituted substance can then be withdrawn from the vial using the syringe. Inner surface of the transfer set may be part of the path of fluid and the aluminum collar or ring can carry particles of aluminum to the sterile room where the substance is added to the vial or to the fluid path that contaminates the substance. Has been attempts to reduce this problem by applying a coating to the Aluminum capsule or collar. Finally the prior art also includes plastic cup-shaped capsules that are fixed by elastic jump they have a protruding limb part radially inward which is fixed by elastic jump on the edge of the vial The plastic collars that are fixed by elastic jump, however, does not ensure a tight seal adequate vial or complete accommodation of the tolerances of standard vials and shutters as required.

A plastic closure to close tightly a container corresponding to the first part of the claim 1 is described in the document FR-A-1,328,635. The closure of plastic comprises a limb wall and a skirt that depends Of the same. When the closure has been positioned on the neck of a container, the skirt is deformed by L-shaped appendages of so that the closure is anchored in the container.

Summary of the invention

It is an object of the invention to provide a closure. for vials and other medical containers that can be used with traditional containers, such as vials or cartridges pharmacists, which ensures the tightness of the container and that get a good level of cleanliness, without metal particles or dust that can contaminate the contents, and that do not expose the Sanitary worker with sharp metal edges.

The plastic closure of this invention that solves these problems and that allows the use of the closure of plastic of this invention to join and close tightly containers is defined by claim 1. In accordance with the invention, the polymer has a creep elongation of between the 5% and 10%, an elongation at break greater than 100% and a module of flexion greater than 1,900 MPa.

The plastic closure to close tightly a cartridge or other medical container of this invention eliminates the problems associated with a metal capsule or collar or of malleable aluminum, but accommodates the accumulation of tolerances of the edge part of the container and the elastomer shutter when it's used. The plastic closure of this invention is relatively Cheap to manufacture and use. The plastic closure of this invention It can be used as a capsule to tightly close a Traditional pharmaceutical cartridge As used here, the Closure term is generic for any capsule or collar.

The plastic closure to close tightly A container of this invention can be used with any number of traditional cartridges that have an open end and a neck portion of reduced diameter adjacent to the end open. The plastic closure of this invention includes a part generally tubular and a part that is radially deformed or bent inward towards the small diameter part of the container to retain the closure of in the container and as a capsule to tightly close the open end of the container. The plastic closure of this invention can also be used as a capsule or collar with a vial and shutter of traditional elastomer. In the preferred embodiment, the closure of plastic of this invention is formed of a polymer that is malleable enough to allow radial deformation, but still rigid enough to retain its shape after deformation and drag resistant enough to maintain the seal between the plastic capsule and the container after radial deformation

The preferred embodiment of the plastic closure of this invention is formed of a composite polymer that includes a polymer alloy or molten mixture that includes a copolymer relatively tenacious soft malleable and a relatively polymer rigid. In the most preferred embodiment of the plastic closure of This invention, the composite polymer is a polymer alloy of a relatively soft malleable copolymer and a polymer relatively rigid The preferred relatively rigid polymer is a polyamide or a polycarbonate and the copolymer relatively Preferred soft can be selected from among the polyesters or polyolefins The resulting alloy or polymer compound has preferably a creep elongation of between 5% and 10% and an elongation at break greater than 100% with a flexural modulus greater than 1900 MPa.

When the container or cartridge includes a radial edge portion adjacent to the open end, the plastic closure of this invention includes a generally cylindrical tubular portion that preferably has an inner diameter generally equal to or slightly greater than the outer diameter of the edge portion of the container intended to be received on the edge portion of the container having a free distal end intended to be radially inwardly deformed or folded inwardly below the edge portion of the container and sealed. The plastic capsule or collar of this invention may also include a radially inwardly projecting proximal portion that covers the edge portion of the container and / or the obturator. This radial part can be closed or more preferably includes a central opening that can be closed with a plastic closure or hermetic closure of the start or take off type. In the preferred embodiment, the detached seal includes a loop-shaped end portion that is welded or glued in situ to provide an indication of violation of the closure and a free end that can be taken to remove the seal.

The method of this invention includes forming a plastic closure that has a generally tubular part cylindrical having a generally equal inside diameter or slightly larger than an outside diameter of the edge part of the container and a part of integral radial edge, arranging the closure on the edge of the container with the radial edge part which covers the edge part of the vial and the tubular part surrounding the edge of the container, and then warp or bend towards radially permanently in the free end of the part tubular collar towards the neck part of the container, by under the edge part, permanently ensuring closure over the container and tightly closing the open end of the  container. In the most preferred embodiment of the method of this invention, the plastic closure of this invention is formed injection molding the plastic closure from a alloy or polymeric compound having a polymer or copolymer relatively soft malleable and a relatively rigid polymer, in which an alloy or polymeric compound is formed during the injection molding. When an elastic ring is used or polymeric to prevent rotation of the closure in the container, the ring can be co-injected with the polymer that forms the closure or an annular throat may form in the tubular part of the closure, next to the free end. The method below includes insert the elastic ring ring in the throat before deformation permanent radial of the free end of the closure as described, such that the elastic ring is loaded against the part of container edge. A thermoplastic elastomer can also be co-injected with the polymer that forms the closure to form a coating or film on the inner surface of the closure which is integral to the polymer of the capsule.

The plastic closure of this invention can be used with a cartridge or other medical container that has a traditional elastomer shutter or as a collar in combination with a transfer set that has a member Hermetic closure as described in the prior art or more preferably the collar part can be formed so integral with transfer set components. When he plastic closure of this invention is used to close tightly a container that has an elastomer shutter, the radial proximal lip of the closure is received on and preferably loaded against the radial elastic lip of the shutter during deformation or radial stressing of the end free of the tubular part of the closure below the edge of the container. The plastic closure of this invention thus eliminates the problems associated with malleable collars or metal capsules, such as aluminum, and it is relatively cheap, and simple to manufacture, particularly when compared with capsules of Aluminum that have a protective coating. The closure of The plastic of this invention ensures an excellent seal of the container and can be injection molded in a clean environment or wash, if necessary. Finally, the plastic closure of This invention accommodates the tolerances of the vial and particularly the accumulation of tolerance variations in the combination of a Traditional elastomer vial and shutter. Other advantages and Merit characteristics of the present invention will be more fully understood from the following description of the preferred embodiments, the appended claims and the drawings, a brief description of which has been given to continuation.

Brief description of the drawings

Fig. 1 is a sectional side view cross section of a preferred embodiment of the plastic closure of this invention secured to a traditional vial that has a shutter of elastomer and the one that closes tightly;

Fig. 2 is a sectional side view cross section exploited from the open end of a traditional vial, elastomer shutter and plastic closure shown in fig. 1 before radial deformation of the free end of the closure;

Fig. 3 is a partially side view cross section of the assembly shown in fig. one illustrates the radial deformation or stress of the closure;

Fig. 4 is a cross-sectional view of a plastic closure of this invention mounted on a cartridge used in an injector device;

Fig. 5 is a close-up view of parts selected from fig. 4;

Fig. 6 is a cross-sectional view of another exemplary cartridge that has this plastic collar invention;

Fig. 7 is a close-up view of parts selected from fig. 6;

Fig. 8 is a cross-sectional view of another exemplary cartridge that has the closure designed in accordance with this invention.

Detailed description of the preferred embodiments

Figs. 1 to 3 illustrate an embodiment preferred of a capsule and shutter set 20, container Pharmaceutical substance of this invention. As described before, the closure of this invention can be used to close hermetically distinct containers and is particularly useful for tightly close containers to contain products Pharmacists such as the traditional vial 22 illustrated in the figs. 1 to 3 and the cartridges shown in figs. 4 to 8. The vial includes an open end 24, an annular edge portion 26 that is extends radially and a neck part 28 adjacent to the part Edge The neck portion 28 of the vial has a reduced diameter when compared to the edge part 26 and the part of container 30. The inner surface 31 of the vial adjacent to the open end 24 is generally cylindrical. The vials of Drugs of this type are usually formed from glass or from a sterilizable plastic The open end 24 of the vial is typically closed with an elastomer shutter 32 having a tubular body part 34 that is received at the open end 24 of the vial and a flat edge portion 36 that covers the portion of edge 26 of the vial as shown in fig. 1. The shutter it is generally formed of an elastic elastomer material such as synthetic or natural rubber. The central part 38 of the part of flat edge 36 can be pierced with a hypodermic needle, by example, to either extract the fluid from the vial or add a solvent or diluent to the vial in which the substance in the vial It is in dry or powdered form. The tubular part 34 of the plug has an outside diameter generally larger than the diameter inside of the inner cylindrical surface 31 of the vial for provide a tight fit or interference.

A preferred embodiment of closure 40 is shown in fig. 1 attached to a set of vial 22 and shutter 32, before assembling in fig. 2 and during assembly in fig. 3. This embodiment of collar 40 includes a tubular part 42 surrounding the edge part 26 of the vial and the flat edge part 36 Shutter When the outer surface of the edge part 26 of the vial is cylindrical, the tubular part 42 of the collar will be also generally cylindrical. As shown in fig. one, the free end 44 of the tubular part 42 is deformed or highlighted below the adjacent surface of the edge part 26 of the vial, permanently securing collar 40 over the vial and tightly closing the vial. This realization of collar 40 also includes a radial integral part proximal 46 covering the edge portions 26 and 36 of the vial and plug, respectively. The radial part 46 is preferably one piece with the tubular part 42 of the collar. This embodiment of the collar 40 also includes a central opening 48 that covers the part central 38 of the shutter, preferably coaxially aligned with the central part of the shutter. As described below, however, the central opening 48 can be removed in certain Applications of this invention. As used here, the terms proximal and distal are used only to facilitate description, in which the proximal term refers to elements or parts of elements closest to the edge part 36 of the shutter and distal refers to elements or parts of elements more away from the edge part of the shutter. In addition, the terms Capsule and collar are used interchangeably here.

Illustrated collar 40 includes a capsule 50 Shallow cup shaped. In the described embodiment, the capsule 50 includes a tubular part 52 that surrounds the proximal part of the part tubular 42 of the collar, a radial integral bridge part 54 central and a plurality of U-shaped appendages that, in the described embodiment, they are one piece with the bridge part central 54. The U-shaped appendices 56 are received through of the central opening 48 of the collar and fixed by elastic jump in place to safely retain capsule 50 in the collar 40. As shown in fig. 2, the capsule 50 can be previously mounted on collar 40 before mounting the collar in the vial. Appendices 56 may also be members separated or the central part of the capsule 50 which includes the Appendices 56 may be a separate member.

The collar 40 is then assembled in vial 22 as shown in fig. 2. In an application typical, the tubular part 34 of the plug is first inserted into the opening 24 of vial 22 generally after the vial is fill. As described above, the plastic collar 40 of This invention can be used with different containers that include Traditional medication vials as shown. So in A typical application, vial 22 will be filled first with a medicine. The tubular part 42 of the collar 40 is then received on the edge part 36 of the shutter and the part of edge 26 of the vial as shown in fig. 3. The end free 44 (shown before deformation in dashed lines in fig. 3) is then deformed radially below the radial edge 26 of the vial by a suitable tool, such as the highlighting tool 58 shown in fig. 3. The realization described of the highlighting tool includes a tapered edge 60 that deforms or highlights the free end 44 of the collar below from the edge 26 of the vial. In a typical application, tool 58 it is rotated around the edge 26 of the collar 40, deforming or highlighting the free end 44 as shown in figs. 1 and 3. In certain applications, it may be desirable to heat either the free end 44 of the collar or tool 58 for facilitate highlighting. The sealed vial can now Be stored for later use.

When the vial is ready to use, the capsule 50 can be removed simply by forcing one side of the capsule 50 upwards away from collar 40, removing capsule 50 from collar 40 and exposing the central opening 48 of the collar and the central part 38 of the shutter. The central part 38 of the shutter it can then be pierced with a hypodermic needle traditional, for example, providing access to the part of vial container 30. When the material of the capsule 50 is selected to provide elasticity, such as polyethylene or Polypropylene, Appendices 56 will bend under the pressure of thumb, allowing easy removal of closure 50. Alternatively, when the capsule material is relatively rigid, at least some of the appendices 56 will break allowing also the withdrawal of the capsule. It should also be noted that the radial part 46 of the collar is preferably compressed against the elastic edge portion 32 of the elastomer seal during the radial deformation of the free end 44 of the collar to ensure a secure seal of the vial after installation. The Appendices 56 are thus compressed at the radial edge 32 of the shutter as shown in fig. one.

The polymer selected for the closure of plastic of this invention can be best described by its required physical properties The polymer must be malleable enough to allow radial deformation or stressed, and rigid enough to retain its shape after of deformation. The polymer must also be sufficiently drag resistant to keep the seal between the plastic capsule and container after deformation radial. It has been found that a polymer that has an elongation to creep between 5% and 10% and elongation at break greater than 100%, combined with a flexural modulus greater than 1,900 Mpa has superior performance. When closing plastic of this invention is used to seal vials containing a medication, the polymer must also be sterilizable and, in certain applications such as the collar of plastic for a vial transfer assembly described more below, the polymer is preferably relatively transparent and maintains its transparency under the strain of deformation or stressed. It has been found that certain polymer alloys or compound polymers including molten mixtures or alloys and copolymers having malleability and stiffness polymers Different are preferred in many applications. That is, the plastic closure of this invention is preferably formed of a polymer alloy, composite polymer or copolymer that includes a relatively rigid polymer and a malleable copolymer Tenacious relatively soft. Most preferred polymers they are an alloy of polymers or a molten mixture that includes a polyamide or polycarbonate as the rigid polymer that provides the desired mechanical strength and drag resistance to This application. The relatively soft malleable copolymer can be selected from different polymers that include polyester and polyolefins; however, a polymer alloy that includes a polycarbonate or polyamide and a Polyester, particularly suitable for this application.

As will be understood, different molten mixtures alloys, polymeric compounds, and copolymers are being developed on a rapidly growing basis and therefore the Plastic collar of this invention is not limited to a polymer specific, provided that the polymer has the properties desired physics described above. Suitable polymers for The plastic collar of this invention includes EASTAR® polymers MB, which are molten mixtures and alloy polymers and polymers EASTAR® thermoplastics, which are pure polymers sold by Eastman Chemical Company of Kingsport, Tennessee and Eastman Chemical AG of Zug, Switzerland under the trade names "DA003, DN003" and "DN004". These materials are molten mixtures, alloys of polymers and copolymers of polycarbonate or polyamide and polyester. As used herein, the terms molten mixtures and alloys refer to polymeric compositions that have two or more polymers of different physical properties or characteristics, such as EASTAR® polymers from Eastman Chemical Company before described that include a polycarbonate or polyamide and a polyester. The polymer selected for this plastic collar invention may also include filters and other constituents that they would be described more exactly as a compound. Although base polymers can still be a molten mixture or alloy polymeric As used herein, the term compound is used in its broadest sense to include alloys or molten mixtures, compounds and copolymers. As will be understood, the manufacturer or Raw material supplier will normally mix the polymers based on customer specifications. Polymers can be co-injected to form a molten mixture, alloy or polymeric compound or formed by any other suitable process. It has been anticipated, however, that other polymers that have the described physical characteristics can also be used in the plastic collar or capsule of this invention. In certain applications, it may also be desirable to coat at least the inner surface 43 of the collar shown in fig. 2 with a thermoplastic elastomer, or the complete collar may have a thin layer of a thermoplastic elastomer. The lining of thermoplastic elastomer can be applied as a film or by co-injection with the polymer that forms the collar 40. The collar 40 and the closure 50 can be formed by processes Traditional injection molding.

Although figures 1 to 3 include a illustration of a generic vial or container for a substance pharmaceutical, this invention is particularly useful for closing Hermetically sealed cartridges that are prefilled with pharmaceutical substances Such cartridges are well known and are typically used with injector devices in which the cartridge is inserted into the appropriate part of the injector device by a medical professional before administering an injection. Typically the cartridges are prefilled with the substance desired pharmaceutical. A variety of cartridge designs are used to accommodate substances in different ways.

Figs. 4 and 5 illustrate an example cartridge which includes a plastic closure 140 designed in accordance with this invention. In this example, cartridge 122 is used within a injector device that has been schematically illustrated in 180. The cartridge 122 includes an open end 124 which is closed by a elastomer shutter member 132 in cooperation with the closure of plastic 140. At the opposite end of cartridge 122, a member shutter 170 serves to keep a substance inside 131 of cartridge 122. Seal member 170 also cooperates with the injector mechanisms schematically illustrated in 160 of the 180 injector in a traditional way.

As can be seen better in fig. 5, the member elastomer shutter 132 extends through opening 124 and includes a part 136 that rests against the edge part 126 of the cartridge 122. A central part 138 of the sealing member 132 is extends through opening 124 and is pierceable by a hypodermic needle device, for example, so that a Pharmaceutical substance inside the cartridge 122 can be injected in the desired way.

Capsule 140 has a part 144 that is stressed or radially deformed inward towards the part of reduced neck 128 of cartridge 122. The radial part 146 of the capsule 140 effectively keeps the sealing member 132 in its site against the end of the step portion 126 of the cartridge 122.

Figs. 6 and 7 illustrate another embodiment specimen in which a plastic closure designed in accordance with This invention is provided at the end of a cartridge 222. In this example, cartridge 222 includes two sealing members 270 and 272. A first substance 276 is held between the shutters 270 and 272 when the cartridge 222 is previously filled by a Pharmaceutical provider, for example. A second substance 278 is held between the shutter 272 and the shutter member 232 in the open end of cartridge 222. A bypass or bypass step 274 is provided so that when an injector mechanism is used and a sealing member 270 is moved towards the end of the cartridge 222 including sealing member 232, sealing member 272 continues in the same direction and the substance or fluid 276 is allowed to flow through bypass 274 to blend with the substance 278. Those skilled in the art will recognize that this type cartridge is especially useful for filled cartridges previously with pharmaceutical substances that are kept in a dry, powdered or lyophilized form. Substance 276 is used typically to reconstitute substances 278 before injecting the substance in a patient.

As can be seen better in fig. 7, the capsule 240 includes the tubular collar part 242 and part 244 stressed or radially deformed that both are applied at least partially to the step part 226 and to the end of the cartridge 222. The sealing member 232 in this embodiment includes a part center 238 and an additional skirt part near end 236 to be applied to the end of the cartridge 222. Otherwise, the operation of the example in figs. 6 and 7 is the same as described previously.

Fig. 8 illustrates another embodiment in which a 340 plastic capsule designed in accordance with this invention is used to seal the end of a 322 cartridge. this example, the cartridge 322 includes a sealing member 338 in the open end 324 and a plunger or plunger member 370 at the opposite end. There are two different cameras 380 and 382 between the diver piston member 370 and sealing member 338. One part 384 that separates the chambers serve to keep substances inside cameras 380 and 382 separated from each other until a sequence desired injection or a desired mixing operation you need be completed The operation of a cartridge multi-camera such as the one illustrated in the fig. 8 is known in the art. The inclusion of a capsule of 340 plastic designed in accordance with this invention provides additional advantages compared to the use of aluminum capsules traditional as described above.

Although several examples of cartridges for maintaining pharmaceutical substances, this invention does not It is limited to these examples. Any number of styles or cartridge configurations that have a neck portion of reduced diameter near the open end, which will accommodate a plastic capsule or closure designed in accordance with this invention, It can be used as will be appreciated by those skilled in the art They have the benefit of this description.

As will be understood, they can be made different modifications to the described exemplary plastic closures of this invention within the purpose of the appended claims. Therefore, the legal protection framework given to this invention only can be determined by studying the claims following.

Claims (18)

1. A plastic closure (40) for sealing a container (22, 122, 222, 322) that has an open end (24, 124, 324) and a small diameter part (28, 128, 228, 328) adjacent to said open end, said plastic closure comprising a polymer that is sufficiently malleable to allow radial deformation, and still rigid enough to retain its shape after deformation and sufficiently resistant to drag to remain in a desired position on said container afterwards of the radial deformation, characterized in that said polymer has a creep elongation of between 5% and 10%, an elongation at break greater than 100%, and a flexural modulus greater than 1,900 Mpa. 2. The plastic closure of the claim 1st, wherein said polymer is relatively transparent and maintains its transparency under strain strain. 3. The plastic closure of the claims 1st or 2nd, wherein said plastic closure comprises a polymer compound that includes a relatively soft malleable polymer and a relatively rigid polymer. 4. The plastic closure of the claim 3rd, wherein said plastic closure comprises an alloy polymer comprising a soft malleable copolymer and said relatively rigid polymer. 5. The plastic closure of claim 3 or 4th, wherein said relatively rigid polymer is a polycarbonate or polyamide. 6. The plastic closure of the claims 3rd or 4th, wherein said relatively soft polymer is a Polyester or polyolefin. 7. The plastic closure of the claim 1st, wherein said plastic closure includes a coating of elastomer on an internal surface of a free end of said tubular part and said bonded elastomer liner entirely to said internal surface. 8. A combination comprising the closure of plastic of one of claims 1 to 7 and a container, in which said container (22, 122, 222, 322) includes a radial edge (26, 126, 226, 326) adjacent to said open end, having said plastic closure a tubular part (42, 142, 242, 342) that surrounding said container edge and a part (44, 144, 244, 344) that is permanently radially deformed towards said part of reduced diameter (28, 128, 228, 328) of said container, said tubular part of said closure including an elastic ring ring retained on an inner surface adjacent to said end free that prevents the rotation of said closure in said container. 9. A combination comprising the closure of plastic of one of claims 1 to 7 and a container, in which said container includes a radial edge (26, 126, 226, 326) adjacent to said open end and an elastomer seal (32, 132, 232, 332) extending through said open end of said container and covering said edge portion of said container, said closure having a tubular part (42, 142, 242, 342) surrounding said edge portion of said container having a free distal end radially deformed inward and that applies to said edge part of said container and a radial part proximal (46, 146, 246, 346) covering said edge portion of said shutter. 10. The combination of claim 9, in which said proximal radial part (46, 146, 246, 346) of said closure includes a central opening (48) that covers a central part (38) of said shutter and said closure that includes a capsule (50) cup-shaped having a tubular part (52) that covers a proximal part of said closure and a radial part covering said central opening of said closure and said capsule secured to said closing by retaining elements received within said opening center of said closure. 11. The combination of claim 10, in which said retaining elements are U-shaped appendages spaced one piece with said capsule received through said central opening of said closure each having a free end which is applied to a part of said closure adjacent to said opening central. 12. The combination of claim 11, in which said container is a cartridge intended to contain a pharmaceutical substance 13. The combination of claim 12, in which said cartridge has at least two cameras. 14. The combination of claim 12, in which said cartridge includes more than one sealing member that moves selectively multiple substances within said cartridge. 15. The combination of claim 12, in which the cartridge has a plurality of cameras. 16. The combination of claim 15, which includes a plurality of shutter members that move inside of the cartridge to selectively separate or mix different substances maintained in the plurality of chambers, respectively. 17. The combination of claim 15, which includes a bypass or bypass that allows selective movement of the substance from one of the plurality of chambers to another of the plurality of cameras. 18. The combination of claim 12, which includes a shutter seal member of elastomer