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Pfizer Health AB
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Pharmacia AB
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Publication date
Application filed by Pharmacia ABfiledCriticalPharmacia AB
Publication of ES224450A1publicationCriticalpatent/ES224450A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Process for producing barbituric acids of general formula: ** (See formula) ** and salts thereof, in which formula R is a tertiary alkyl group preferably containing at most 7 carbon atoms, and denote hydrogen, alkyl or alkenyl groups, which preferably contain at most 4 carbon atoms each, and X is oxygen, NH or sulfur, characterized in that an ester of the general formula ** (See formula) ** wherein R and R1 have the same meaning as indicated above, denotes an alcohol group, which preferably contains at most 5 carbon atoms, and Y denotes the CN or COOR4 group where R4 is an alcohol group, which preferably contains at most 5 carbon atoms, is condensed with a carbamide derivative of the formula NH2CXNHR2 or salts thereof, where R2 and X have the same meaning as indicated above, in the presence of a solvent and a strongly basic catalyst, after whereof the compound thus obtained, if desired, is subjected to hydrolysis. (Machine-translation by Google Translate, not legally binding)
ES0224450A1954-10-141955-10-13A procedure to produce new barbituric acid derivatives (Machine-translation by Google Translate, not legally binding)
ExpiredES224450A1
(en)