ES2196638T3 - Compuestos para espectrometria de masa conteniendo bases de acidos nucleicos y marcadores de masa con eter de arilo. - Google Patents
Compuestos para espectrometria de masa conteniendo bases de acidos nucleicos y marcadores de masa con eter de arilo.Info
- Publication number
- ES2196638T3 ES2196638T3 ES98962569T ES98962569T ES2196638T3 ES 2196638 T3 ES2196638 T3 ES 2196638T3 ES 98962569 T ES98962569 T ES 98962569T ES 98962569 T ES98962569 T ES 98962569T ES 2196638 T3 ES2196638 T3 ES 2196638T3
- Authority
- ES
- Spain
- Prior art keywords
- mass
- arilo
- eter
- compounds
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6872—Methods for sequencing involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Una serie de marcadores de masa, comprendiendo cada marcador de masa en la serie un éter arílico, donde la serie comprende una pluralidad de series de marcadores de masa, comprendiendo cada serie de marcadores de masa una pluralidad de diferentes marcadores de masa, difiriendo en masa, cada marcador de masa de una serie cualquiera, de todos los los demás marcadores en esa serie por una masa de al menos sustancialmente 4 Daltons y teniendo cada marcador de masas en una serie cualquiera el mismo número de unidades de éter arílico que los otros marcadores de masa de esa serie y un número diferente de unidades de éter arílico de los demás marcadores de otra serie cualquiera.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9726953.4A GB9726953D0 (en) | 1997-12-19 | 1997-12-19 | Hybridisation probes |
GBGB9815163.2A GB9815163D0 (en) | 1998-07-13 | 1998-07-13 | Compounds |
GBGB9815164.0A GB9815164D0 (en) | 1998-07-13 | 1998-07-13 | Compounds for mass spectrometry |
GBGB9815166.5A GB9815166D0 (en) | 1998-07-13 | 1998-07-13 | Compounds for mass spectrometry |
GBGB9823646.6A GB9823646D0 (en) | 1997-12-19 | 1998-10-28 | Compounds for mass spectrometry |
PCT/GB1998/003842 WO1999032501A1 (en) | 1997-12-19 | 1998-12-18 | Compounds for mass spectrometry comprising nucleic acid bases and aryl ether mass markers |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196638T3 true ES2196638T3 (es) | 2003-12-16 |
Family
ID=27517439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98962569T Expired - Lifetime ES2196638T3 (es) | 1997-12-19 | 1998-12-18 | Compuestos para espectrometria de masa conteniendo bases de acidos nucleicos y marcadores de masa con eter de arilo. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6287780B1 (es) |
EP (1) | EP1042345B1 (es) |
AT (1) | ATE237626T1 (es) |
AU (1) | AU1770499A (es) |
DE (1) | DE69813622T2 (es) |
DK (1) | DK1042345T3 (es) |
ES (1) | ES2196638T3 (es) |
GB (1) | GB9823646D0 (es) |
PT (1) | PT1042345E (es) |
WO (1) | WO1999032501A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU734636B2 (en) * | 1997-07-11 | 2001-06-21 | Xzillion Gmbh & Co. Kg | Characterising nucleic acids |
GB9815163D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds |
GB9815164D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
GB9815166D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
US6379971B1 (en) | 1998-02-24 | 2002-04-30 | Target Discovery, Inc. | Methods for sequencing proteins |
US7399844B2 (en) | 1998-07-09 | 2008-07-15 | Agilent Technologies, Inc. | Method and reagents for analyzing the nucleotide sequence of nucleic acids |
US6764817B1 (en) | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
US6716636B1 (en) | 1999-04-20 | 2004-04-06 | Target Discovery, Inc. | Methods for sequencing proteins |
GB0006141D0 (en) * | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
WO2002004936A1 (en) * | 2000-07-11 | 2002-01-17 | Japan Science And Technology Corporation | Probe for mass spectrometry of liquid sample |
JP2004506900A (ja) * | 2000-08-11 | 2004-03-04 | アジリックス・コーポレイション | 超高感度検出システム |
WO2002061661A2 (en) * | 2000-10-19 | 2002-08-08 | Target Discovery, Inc. | Methods for determining protein and peptide terminal sequences |
DE60223696T2 (de) | 2001-09-14 | 2009-01-29 | Electrophoretics Ltd., Cobham | Massenmarker |
JP4754831B2 (ja) | 2002-10-29 | 2011-08-24 | ターゲット・ディスカバリー・インコーポレイテッド | 質量分析法のイオン化効率の増大方法 |
WO2004070352A2 (en) * | 2003-01-30 | 2004-08-19 | Applera Corporation | Methods, mixtures, kits and compositions pertaining to analyte determination |
JP4838725B2 (ja) * | 2003-11-26 | 2011-12-14 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | クワイエットゾーン中の質量スペクトルデータの分析 |
US7355045B2 (en) * | 2004-01-05 | 2008-04-08 | Applera Corporation | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof |
US20050148771A1 (en) * | 2004-01-05 | 2005-07-07 | Applera Corporation. | Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof |
US20050148087A1 (en) * | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
CA2557997C (en) * | 2004-03-01 | 2012-01-31 | Applera Corporation | Determination of analyte characteristics based upon binding properties |
US20070048752A1 (en) * | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
EP1776588A1 (en) * | 2004-07-12 | 2007-04-25 | Applera Corporation | Mass tags for quantitative analyses |
US20060183238A1 (en) * | 2005-02-09 | 2006-08-17 | Applera Corporation | Amine-containing compound analysis methods |
US20070037286A1 (en) * | 2005-02-09 | 2007-02-15 | Subhasish Purkayastha | Thyroxine-containing compound analysis methods |
GB0518585D0 (en) | 2005-09-12 | 2005-10-19 | Electrophoretics Ltd | Mass labels |
US8975404B2 (en) | 2006-01-24 | 2015-03-10 | Dh Technologies Development Pte. Ltd. | Labeling reagents for analyte determination and methods and compounds used in making the same |
CN101454488A (zh) * | 2006-05-26 | 2009-06-10 | 阿普里拉股份有限公司 | 用于羟基化化合物的标签试剂和方法 |
US7906341B2 (en) * | 2006-06-30 | 2011-03-15 | Dh Technologies Development Pte, Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
US8362242B2 (en) * | 2006-06-30 | 2013-01-29 | Dh Technologies Development Pte. Ltd. | Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label |
US8486712B2 (en) | 2009-03-10 | 2013-07-16 | University Of Maryland, College Park | Deuterium isobaric tag reagents for quantitative analysis |
US8492163B2 (en) | 2011-01-31 | 2013-07-23 | Dh Technologies Development Pte. Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
US10345281B2 (en) | 2014-04-04 | 2019-07-09 | Massachusetts Institute Of Technology | Reagents for enhanced detection of low volatility analytes |
US9588095B2 (en) | 2012-07-24 | 2017-03-07 | Massachusetts Institute Of Technology | Reagents for oxidizer-based chemical detection |
US9891193B2 (en) | 2012-07-24 | 2018-02-13 | Massachusetts Institute Of Technology | Reagent impregnated swipe for chemical detection |
WO2014058508A2 (en) * | 2012-07-24 | 2014-04-17 | Massachusetts Institute Of Technology | Reagents for oxidizer-based chemical detection |
US10816530B2 (en) | 2013-07-23 | 2020-10-27 | Massachusetts Institute Of Technology | Substrate containing latent vaporization reagents |
CN116496335B (zh) * | 2023-03-21 | 2024-03-08 | 中国药科大学 | 一种修饰核苷酸及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL57571A (en) | 1978-06-22 | 1983-03-31 | Miles Lab | Flavin adenine dinucleotide-labeled conjugates and their use in a homogeneous immunoassay method for determining haptens |
CA2114355A1 (en) | 1993-01-29 | 1994-07-30 | Hidehiko Furukawa | Modified oligodeoxyribonucleotides, their preparation and their therapeutic use |
ES2143848T3 (es) * | 1996-01-23 | 2000-05-16 | Rapigene Inc | Metodos para detectar la fijacion de una pareja de ligandos con sensibilidad mejorada. |
DE69836013T2 (de) | 1997-01-15 | 2007-05-24 | Xzillion Gmbh & Co. Kg | Massenmarkierte hybridisierungssonden |
-
1998
- 1998-10-28 GB GBGB9823646.6A patent/GB9823646D0/en not_active Ceased
- 1998-12-18 DK DK98962569T patent/DK1042345T3/da active
- 1998-12-18 ES ES98962569T patent/ES2196638T3/es not_active Expired - Lifetime
- 1998-12-18 DE DE69813622T patent/DE69813622T2/de not_active Expired - Fee Related
- 1998-12-18 EP EP98962569A patent/EP1042345B1/en not_active Expired - Lifetime
- 1998-12-18 AT AT98962569T patent/ATE237626T1/de not_active IP Right Cessation
- 1998-12-18 WO PCT/GB1998/003842 patent/WO1999032501A1/en active IP Right Grant
- 1998-12-18 PT PT98962569T patent/PT1042345E/pt unknown
- 1998-12-18 AU AU17704/99A patent/AU1770499A/en not_active Abandoned
- 1998-12-18 US US09/581,792 patent/US6287780B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB9823646D0 (en) | 1998-12-23 |
ATE237626T1 (de) | 2003-05-15 |
EP1042345B1 (en) | 2003-04-16 |
US6287780B1 (en) | 2001-09-11 |
DE69813622T2 (de) | 2003-12-11 |
DK1042345T3 (da) | 2003-08-11 |
EP1042345A1 (en) | 2000-10-11 |
DE69813622D1 (de) | 2003-05-22 |
PT1042345E (pt) | 2003-09-30 |
AU1770499A (en) | 1999-07-12 |
WO1999032501A1 (en) | 1999-07-01 |
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