DE69813622D1 - Verbindungen für massenspektrometrie bestehend aus nukleinsäure-basen und arylether-massmarkern - Google Patents
Verbindungen für massenspektrometrie bestehend aus nukleinsäure-basen und arylether-massmarkernInfo
- Publication number
- DE69813622D1 DE69813622D1 DE69813622T DE69813622T DE69813622D1 DE 69813622 D1 DE69813622 D1 DE 69813622D1 DE 69813622 T DE69813622 T DE 69813622T DE 69813622 T DE69813622 T DE 69813622T DE 69813622 D1 DE69813622 D1 DE 69813622D1
- Authority
- DE
- Germany
- Prior art keywords
- mass
- nucleic acid
- arylether
- connections
- acid bases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6872—Methods for sequencing involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9726953.4A GB9726953D0 (en) | 1997-12-19 | 1997-12-19 | Hybridisation probes |
GBGB9815163.2A GB9815163D0 (en) | 1998-07-13 | 1998-07-13 | Compounds |
GBGB9815166.5A GB9815166D0 (en) | 1998-07-13 | 1998-07-13 | Compounds for mass spectrometry |
GBGB9815164.0A GB9815164D0 (en) | 1998-07-13 | 1998-07-13 | Compounds for mass spectrometry |
GBGB9823646.6A GB9823646D0 (en) | 1997-12-19 | 1998-10-28 | Compounds for mass spectrometry |
PCT/GB1998/003842 WO1999032501A1 (en) | 1997-12-19 | 1998-12-18 | Compounds for mass spectrometry comprising nucleic acid bases and aryl ether mass markers |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69813622D1 true DE69813622D1 (de) | 2003-05-22 |
DE69813622T2 DE69813622T2 (de) | 2003-12-11 |
Family
ID=27517439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69813622T Expired - Fee Related DE69813622T2 (de) | 1997-12-19 | 1998-12-18 | Verbindungen für massenspektrometrie bestehend aus nukleinsäure-basen und arylether-massmarkern |
Country Status (10)
Country | Link |
---|---|
US (1) | US6287780B1 (de) |
EP (1) | EP1042345B1 (de) |
AT (1) | ATE237626T1 (de) |
AU (1) | AU1770499A (de) |
DE (1) | DE69813622T2 (de) |
DK (1) | DK1042345T3 (de) |
ES (1) | ES2196638T3 (de) |
GB (1) | GB9823646D0 (de) |
PT (1) | PT1042345E (de) |
WO (1) | WO1999032501A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ502088A (en) * | 1997-07-11 | 2002-05-31 | Brax Group Ltd | Characterising nucleic acids using mass spectroscopy |
GB9815166D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
GB9815163D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds |
GB9815164D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
US6379971B1 (en) | 1998-02-24 | 2002-04-30 | Target Discovery, Inc. | Methods for sequencing proteins |
US7399844B2 (en) | 1998-07-09 | 2008-07-15 | Agilent Technologies, Inc. | Method and reagents for analyzing the nucleotide sequence of nucleic acids |
US6716636B1 (en) | 1999-04-20 | 2004-04-06 | Target Discovery, Inc. | Methods for sequencing proteins |
US6764817B1 (en) | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
GB0006141D0 (en) | 2000-03-14 | 2000-05-03 | Brax Group Ltd | Mass labels |
WO2002004936A1 (en) * | 2000-07-11 | 2002-01-17 | Japan Science And Technology Corporation | Probe for mass spectrometry of liquid sample |
AU8356201A (en) * | 2000-08-11 | 2002-02-25 | Agilix Corp | Ultra-sensitive detection systems |
CA2426580C (en) | 2000-10-19 | 2011-09-13 | Target Discovery, Inc. | Mass defect labeling for the determination of oligomer sequences |
DE60223696T2 (de) | 2001-09-14 | 2009-01-29 | Electrophoretics Ltd., Cobham | Massenmarker |
AU2003304026B2 (en) | 2002-10-29 | 2010-03-25 | Target Discovery, Inc. | Method for increasing ionization efficiency in mass spectroscopy |
CA2488584C (en) * | 2003-01-30 | 2011-10-11 | Applera Corporation | Methods, mixtures, kits and compositions pertaining to analyte determination |
JP4838725B2 (ja) * | 2003-11-26 | 2011-12-14 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | クワイエットゾーン中の質量スペクトルデータの分析 |
US7307169B2 (en) * | 2004-01-05 | 2007-12-11 | Applera Corporation | Isotopically enriched N-substituted piperazines and methods for the preparation thereof |
US20050148087A1 (en) * | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
US7355045B2 (en) * | 2004-01-05 | 2008-04-08 | Applera Corporation | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof |
CA2557997C (en) * | 2004-03-01 | 2012-01-31 | Applera Corporation | Determination of analyte characteristics based upon binding properties |
CA2572754A1 (en) * | 2004-07-12 | 2006-02-16 | Applera Corporation | Mass tags for quantitative analyses |
US20070048752A1 (en) * | 2004-07-12 | 2007-03-01 | Applera Corporation | Mass tags for quantitative analyses |
US20070037286A1 (en) * | 2005-02-09 | 2007-02-15 | Subhasish Purkayastha | Thyroxine-containing compound analysis methods |
US20060183238A1 (en) | 2005-02-09 | 2006-08-17 | Applera Corporation | Amine-containing compound analysis methods |
GB0518585D0 (en) | 2005-09-12 | 2005-10-19 | Electrophoretics Ltd | Mass labels |
US8975404B2 (en) | 2006-01-24 | 2015-03-10 | Dh Technologies Development Pte. Ltd. | Labeling reagents for analyte determination and methods and compounds used in making the same |
WO2007140380A2 (en) * | 2006-05-26 | 2007-12-06 | Applera Corporation | Tagging reagents and methods for hydroxylated compounds |
US7906341B2 (en) * | 2006-06-30 | 2011-03-15 | Dh Technologies Development Pte, Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
US8362242B2 (en) * | 2006-06-30 | 2013-01-29 | Dh Technologies Development Pte. Ltd. | Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label |
US8486712B2 (en) | 2009-03-10 | 2013-07-16 | University Of Maryland, College Park | Deuterium isobaric tag reagents for quantitative analysis |
US8492163B2 (en) | 2011-01-31 | 2013-07-23 | Dh Technologies Development Pte. Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
US10345281B2 (en) | 2014-04-04 | 2019-07-09 | Massachusetts Institute Of Technology | Reagents for enhanced detection of low volatility analytes |
US9588095B2 (en) | 2012-07-24 | 2017-03-07 | Massachusetts Institute Of Technology | Reagents for oxidizer-based chemical detection |
US9891193B2 (en) | 2012-07-24 | 2018-02-13 | Massachusetts Institute Of Technology | Reagent impregnated swipe for chemical detection |
WO2014058508A2 (en) * | 2012-07-24 | 2014-04-17 | Massachusetts Institute Of Technology | Reagents for oxidizer-based chemical detection |
US10816530B2 (en) | 2013-07-23 | 2020-10-27 | Massachusetts Institute Of Technology | Substrate containing latent vaporization reagents |
CN116496335B (zh) * | 2023-03-21 | 2024-03-08 | 中国药科大学 | 一种修饰核苷酸及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2924332A1 (de) | 1978-06-22 | 1980-01-03 | Miles Lab | Flavin-adenin-dinukleotid-markiertes konjugat und dessen verwendung in spezifischen bindungsversuchen |
CA2114355A1 (en) | 1993-01-29 | 1994-07-30 | Hidehiko Furukawa | Modified oligodeoxyribonucleotides, their preparation and their therapeutic use |
DE69700902T2 (de) | 1996-01-23 | 2000-07-20 | Rapigene Inc | Verfahren zur erkennung von ligandenpaar bindung mit erhöter empfindlichkeit |
IL130885A (en) * | 1997-01-15 | 2005-05-17 | Xzillion Gmbh & Co Kg | Hybridisation probes comprising a base sequence cleavably linked to a mass label and uses thereof |
-
1998
- 1998-10-28 GB GBGB9823646.6A patent/GB9823646D0/en not_active Ceased
- 1998-12-18 DE DE69813622T patent/DE69813622T2/de not_active Expired - Fee Related
- 1998-12-18 US US09/581,792 patent/US6287780B1/en not_active Expired - Fee Related
- 1998-12-18 ES ES98962569T patent/ES2196638T3/es not_active Expired - Lifetime
- 1998-12-18 PT PT98962569T patent/PT1042345E/pt unknown
- 1998-12-18 AU AU17704/99A patent/AU1770499A/en not_active Abandoned
- 1998-12-18 AT AT98962569T patent/ATE237626T1/de not_active IP Right Cessation
- 1998-12-18 EP EP98962569A patent/EP1042345B1/de not_active Expired - Lifetime
- 1998-12-18 DK DK98962569T patent/DK1042345T3/da active
- 1998-12-18 WO PCT/GB1998/003842 patent/WO1999032501A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DE69813622T2 (de) | 2003-12-11 |
WO1999032501A1 (en) | 1999-07-01 |
PT1042345E (pt) | 2003-09-30 |
GB9823646D0 (en) | 1998-12-23 |
ES2196638T3 (es) | 2003-12-16 |
DK1042345T3 (da) | 2003-08-11 |
AU1770499A (en) | 1999-07-12 |
EP1042345B1 (de) | 2003-04-16 |
US6287780B1 (en) | 2001-09-11 |
EP1042345A1 (de) | 2000-10-11 |
ATE237626T1 (de) | 2003-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69813622T2 (de) | Verbindungen für massenspektrometrie bestehend aus nukleinsäure-basen und arylether-massmarkern | |
RS49673B (sr) | Inhibitori sintaze azot-monoksida | |
ATE37375T1 (de) | Phosphonyl-hydroxyacyl-aminosaeure-derivate und ihre verwendung als antihypertensiva. | |
BR9810163B1 (pt) | compostos liberadores de àxido nÍtricos. | |
DK1095053T3 (da) | Arylsulfonlinkere til massespektrometrisk analyse | |
ATE310009T1 (de) | Reaktionssysteme zur herstellung von n- (phosphonomethyl)glyzin verbindungen | |
DE69812634D1 (de) | Metalloproteinase-inhibitoren | |
HRPK20030233B3 (en) | Process for the preparation of substituted phenylacetonitriles | |
BR9902084A (pt) | Heterociclos. | |
DE60106277D1 (de) | Katalysatoren | |
DE60101784D1 (de) | Synthese von wasserlöslischem 9-dihydroplacitaxel derivate aus 9-dihydro-13-acetylbacchatin iii | |
DE60213986D1 (de) | Neuen reagenzien in chemilumineszenz-nachweisverfahren | |
ATE346087T1 (de) | Hepatitis e-virus aus dem schwein und dessen verwendungen | |
BR0004787A (pt) | Processo para a preparação de compostos pirazolo[4,3-d] pirimidin-7-onas-3-piridilsulfonila bem como intermediários dos mesmos | |
DK1347965T3 (da) | Hidtil ukendte desloratidinsalte, fremgangsmåde til syntese deraf samt farmaceutiske præparater deraf | |
HN1999000027A (es) | Nuevas composiciones herbicidas | |
DK1250335T3 (da) | Fremgangsmåde og mellemprodukter til fremstilling af imidazopyridiner | |
ATE157985T1 (de) | Antiparasitisches mittel | |
CA2337207A1 (en) | SILICON-CONTAINING BINDERS FOR NUCLEIC ACID MASS MARKERS | |
DK1423385T3 (da) | Mellemprodukter til fremstilling af neuraminidaseinhibitorkonjugater | |
TH26544A (th) | อนุพันธ์กรด -4 - อัลคิลไทโอ -ไพรมิดิน -5 - อิล อาซีติก | |
GB1467942A (en) | Amine condensate | |
AR029484A4 (es) | Sistema de recaudacion dirigida de ingresos | |
TH53194A (th) | สารประกอบอะมิดีน และการใช้พวกมันเป็นเสมือนสารกำจัดสัตว์รบกวน | |
TH55761B (th) | โพรดรักของสารประกอบแอโซลชนิดที่ละลายน้ำได้ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |