ES2196571T3 - Uso de dextrano y otros polisacaridos para mejorar la depuracion de mucosidades. - Google Patents

Uso de dextrano y otros polisacaridos para mejorar la depuracion de mucosidades.

Info

Publication number
ES2196571T3
ES2196571T3 ES98930598T ES98930598T ES2196571T3 ES 2196571 T3 ES2196571 T3 ES 2196571T3 ES 98930598 T ES98930598 T ES 98930598T ES 98930598 T ES98930598 T ES 98930598T ES 2196571 T3 ES2196571 T3 ES 2196571T3
Authority
ES
Spain
Prior art keywords
improve
mucus
dextran
polysacarids
mucosities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98930598T
Other languages
English (en)
Inventor
Malcolm King
David P Speert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Alberta
University of British Columbia
Original Assignee
University of Alberta
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Alberta, University of British Columbia filed Critical University of Alberta
Application granted granted Critical
Publication of ES2196571T3 publication Critical patent/ES2196571T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Esta invención se refiere al empleo de un polisacárido tal como polidextran para mejorar la limpieza de mucosa. En la presente invención, el dextran ha mostrado reducir la viscoelasticidad y aumentar la eliminación de mucus de esputum de pacientes con fibrosis cística. El dextran también reduce la viscoelasticidad del mucus de perros sanos. La presente invención se puede emplear para mejorar la limpieza o eliminación de mucus en pacientes con fibrosis cística y tratamiento de otros trastornos asociados con defecto en la limpieza de mucus de las vías aéreas incluyendo bronquitis crónica, bronquiectasis y asma bronquial.
ES98930598T 1997-06-30 1998-06-30 Uso de dextrano y otros polisacaridos para mejorar la depuracion de mucosidades. Expired - Lifetime ES2196571T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002209342A CA2209342A1 (en) 1997-06-30 1997-06-30 Use of dextran and other oligomeric saccharides to improve airway clearance
CA002233805A CA2233805A1 (en) 1997-06-30 1998-03-31 Use of dextran and other polysaccharides to improve mucus clearance

Publications (1)

Publication Number Publication Date
ES2196571T3 true ES2196571T3 (es) 2003-12-16

Family

ID=25679458

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98930598T Expired - Lifetime ES2196571T3 (es) 1997-06-30 1998-06-30 Uso de dextrano y otros polisacaridos para mejorar la depuracion de mucosidades.

Country Status (9)

Country Link
EP (1) EP0988041B1 (es)
AT (1) ATE237335T1 (es)
AU (1) AU741849B2 (es)
CA (2) CA2209342A1 (es)
DE (1) DE69813549T2 (es)
ES (1) ES2196571T3 (es)
HK (1) HK1026854A1 (es)
NZ (1) NZ501802A (es)
WO (1) WO1999001141A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001269263A1 (en) * 2000-07-01 2002-01-14 Innovata Biomed Limited Medicaments containing dextrin for treating respiratory disorders such as cysticfibrosis
GB0327723D0 (en) 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
WO2008003682A1 (en) * 2006-07-06 2008-01-10 Novartis Ag Non invasive method for assessing mucus clearance

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015216A1 (en) * 1990-04-05 1991-10-17 Kennedy Thomas P Method and medicament for prevention or medication of human leucocyte elastase-mediated pulmonary diseases
US5514665A (en) * 1993-12-30 1996-05-07 University Of British Columbia Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans

Also Published As

Publication number Publication date
DE69813549T2 (de) 2004-02-26
WO1999001141A1 (en) 1999-01-14
AU741849B2 (en) 2001-12-13
ATE237335T1 (de) 2003-05-15
NZ501802A (en) 2002-03-28
EP0988041B1 (en) 2003-04-16
AU8098098A (en) 1999-01-25
EP0988041A1 (en) 2000-03-29
CA2209342A1 (en) 1998-12-30
DE69813549D1 (de) 2003-05-22
CA2233805A1 (en) 1998-12-30
HK1026854A1 (en) 2000-12-29

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