ES2192870T3 - Derivados de benzofurano, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de benzofurano, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2192870T3
ES2192870T3 ES99956121T ES99956121T ES2192870T3 ES 2192870 T3 ES2192870 T3 ES 2192870T3 ES 99956121 T ES99956121 T ES 99956121T ES 99956121 T ES99956121 T ES 99956121T ES 2192870 T3 ES2192870 T3 ES 2192870T3
Authority
ES
Spain
Prior art keywords
benzofuran
derivatives
application
compositions containing
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99956121T
Other languages
English (en)
Inventor
Denis Carniato
Thomas R Gadek
Jean-Francois Gourvest
Jochen Knolle
Anurschirwan Peyman
Sarah C Bodary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Genentech Inc
Original Assignee
Aventis Pharma SA
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA, Genentech Inc filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2192870T3 publication Critical patent/ES2192870T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención tiene por objeto los compuestos de fórmula (I) **(Fórmula)** en la que R1, R2, R4, R5 y R7 tienen los significados indicados más abajo, sus sales fisiológicamente aceptables y sus profármacos. Los compuestos de fórmula (I) son compuestos que tienen actividad farmacológica y por tanto se pueden utilizar en calidad de medicamentos. Son antagonistas del receptor de la vitronectina e inhibidores de la adhesión celular e inhiben la resorción ósea mediada por los osteoclastos. Son por tanto útiles para el tratamiento terapéutico o la profilaxis de enfermedades que se deben, al menos en parte, a un aumento no deseado de la resorción ósea, por ejemplo la osteoporosis.
ES99956121T 1998-11-24 1999-11-23 Derivados de benzofurano, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2192870T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9814779A FR2786184B1 (fr) 1998-11-24 1998-11-24 Nouveaux derives du benzofurane, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ES2192870T3 true ES2192870T3 (es) 2003-10-16

Family

ID=9533118

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99956121T Expired - Lifetime ES2192870T3 (es) 1998-11-24 1999-11-23 Derivados de benzofurano, su procedimiento de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.

Country Status (8)

Country Link
US (2) US6458801B1 (es)
EP (1) EP1133491B1 (es)
JP (1) JP4522586B2 (es)
AT (1) ATE232859T1 (es)
DE (1) DE69905490T2 (es)
ES (1) ES2192870T3 (es)
FR (1) FR2786184B1 (es)
WO (1) WO2000031070A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1176145A1 (en) * 2000-07-28 2002-01-30 Aventis Pharma Deutschland GmbH Novel guanidino derivatives as inhibitors of cell adhesion
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559127A (en) * 1992-10-14 1996-09-24 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9408577D0 (en) * 1994-04-29 1994-06-22 Fujisawa Pharmaceutical Co New compound
WO1995032710A1 (en) * 1994-05-27 1995-12-07 Merck & Co., Inc. Compounds for inhibiting osteoclast-mediated bone resorption
GB9522007D0 (en) * 1995-10-27 1996-01-03 Fujisawa Pharmaceutical Co New compound
US5955495A (en) * 1996-05-03 1999-09-21 Hoffmann-La Roche Inc. Method of treating diseases of the CNS
GB9614347D0 (en) * 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
DE19629816A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
US5981514A (en) * 1998-02-12 1999-11-09 Somberg; John C. (N-alkyl-N-hydroxymethylamino)alkoxybenzoylbenzofurans and the phosphate esters thereof

Also Published As

Publication number Publication date
US6586442B2 (en) 2003-07-01
JP2002530403A (ja) 2002-09-17
EP1133491A1 (fr) 2001-09-19
WO2000031070A1 (fr) 2000-06-02
DE69905490T2 (de) 2003-07-24
US6458801B1 (en) 2002-10-01
JP4522586B2 (ja) 2010-08-11
FR2786184A1 (fr) 2000-05-26
EP1133491B1 (fr) 2003-02-19
FR2786184B1 (fr) 2002-09-20
US20020187976A1 (en) 2002-12-12
DE69905490D1 (de) 2003-03-27
ATE232859T1 (de) 2003-03-15

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