ES2192494A1 - Derivados de 1,2,4-triazol con propiedades cannabinoides. - Google Patents
Derivados de 1,2,4-triazol con propiedades cannabinoides.Info
- Publication number
- ES2192494A1 ES2192494A1 ES200200740A ES200200740A ES2192494A1 ES 2192494 A1 ES2192494 A1 ES 2192494A1 ES 200200740 A ES200200740 A ES 200200740A ES 200200740 A ES200200740 A ES 200200740A ES 2192494 A1 ES2192494 A1 ES 2192494A1
- Authority
- ES
- Spain
- Prior art keywords
- triazole derivatives
- cannabinoid
- properties
- cannabinoid properties
- sufferers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de 1,2,4-triazol con propiedades cannabinoides. La presente invención se refiere a nuevos derivados de triazol con propiedades cannabinoides, en concreto derivados de 1,2,4-triazol con propiedades cannabinoides. Las aplicaciones terapéuticas principales de los compuestos según la invención y debido a su naturaleza antagonista, entre otros, son la supresión del apetito, la reducción de disquinesia provocada por L-dopa en enfermos de Parkinson, el tratamiento de esquizofrenia aguda y una mejora de las disfunciones cognitivas y de memoria asociadas a la enfermedad de Alzheimer.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200200740A ES2192494B1 (es) | 2002-03-27 | 2002-03-27 | Derivados de 1,2,4-triazol con propiedades cannabinoides. |
AU2003215687A AU2003215687A1 (en) | 2002-03-27 | 2003-03-18 | 1,2,4-triazole derivatives with cannabinoid properties |
PCT/ES2003/000126 WO2003082833A1 (es) | 2002-03-27 | 2003-03-18 | Derivados de 1,2,4-triazol con propiedades cannabinoides. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200200740A ES2192494B1 (es) | 2002-03-27 | 2002-03-27 | Derivados de 1,2,4-triazol con propiedades cannabinoides. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2192494A1 true ES2192494A1 (es) | 2003-10-01 |
ES2192494B1 ES2192494B1 (es) | 2005-02-16 |
Family
ID=28459667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200200740A Expired - Fee Related ES2192494B1 (es) | 2002-03-27 | 2002-03-27 | Derivados de 1,2,4-triazol con propiedades cannabinoides. |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003215687A1 (es) |
ES (1) | ES2192494B1 (es) |
WO (1) | WO2003082833A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
US7247628B2 (en) | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
AU2003300967B2 (en) | 2002-12-19 | 2009-05-28 | Merck Sharp & Dohme Corp. | Substituted amides |
US7176210B2 (en) | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
US7268133B2 (en) | 2003-04-23 | 2007-09-11 | Pfizer, Inc. Patent Department | Cannabinoid receptor ligands and uses thereof |
US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
US7232823B2 (en) | 2003-06-09 | 2007-06-19 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
JP4436369B2 (ja) | 2004-01-28 | 2010-03-24 | エフ.ホフマン−ラ ロシュ アーゲー | スピロ−ベンゾジオキソール類およびそれらのcb1アンタゴニストとしての使用 |
TW200602314A (en) | 2004-05-28 | 2006-01-16 | Tanabe Seiyaku Co | A novel pyrrolidine compound and a process for preparing the same |
US20060025448A1 (en) | 2004-07-22 | 2006-02-02 | Cadila Healthcare Limited | Hair growth stimulators |
EP1812418B1 (en) | 2004-11-09 | 2010-10-27 | F. Hoffmann-La Roche AG | Dibenzosuberone derivatives |
US7632837B2 (en) | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
AU2006264649A1 (en) | 2005-06-30 | 2007-01-11 | Prosidion Limited | GPCR agonists |
GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
CL2008000018A1 (es) | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
WO2008081208A1 (en) | 2007-01-04 | 2008-07-10 | Prosidion Limited | Piperidine gpcr agonists |
AR064736A1 (es) | 2007-01-04 | 2009-04-22 | Prosidion Ltd | Agonistas de gpcr |
WO2008081204A1 (en) | 2007-01-04 | 2008-07-10 | Prosidion Limited | Piperidine gpcr agonists |
GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
TW201021797A (en) | 2008-12-04 | 2010-06-16 | Nat Univ Tsing Hua | 1,2,3-triazole derivatives as new cannabinoid-1 receptor antagonists |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3984558A (en) * | 1973-05-21 | 1976-10-05 | Merck & Co., Inc. | 1,3,5-Trisubstituted-1,2,4-triazole compounds used as bronchodilators |
JPH08245315A (ja) * | 1995-03-16 | 1996-09-24 | Nippon Soda Co Ltd | トリアゾール誘導体および有害生物防除剤 |
WO1997049395A1 (en) * | 1996-06-25 | 1997-12-31 | Novartis-Erfindungen Verwaltungsgesellschaft M.B.H. | Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators |
-
2002
- 2002-03-27 ES ES200200740A patent/ES2192494B1/es not_active Expired - Fee Related
-
2003
- 2003-03-18 AU AU2003215687A patent/AU2003215687A1/en not_active Abandoned
- 2003-03-18 WO PCT/ES2003/000126 patent/WO2003082833A1/es not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3984558A (en) * | 1973-05-21 | 1976-10-05 | Merck & Co., Inc. | 1,3,5-Trisubstituted-1,2,4-triazole compounds used as bronchodilators |
JPH08245315A (ja) * | 1995-03-16 | 1996-09-24 | Nippon Soda Co Ltd | トリアゾール誘導体および有害生物防除剤 |
WO1997049395A1 (en) * | 1996-06-25 | 1997-12-31 | Novartis-Erfindungen Verwaltungsgesellschaft M.B.H. | Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators |
Non-Patent Citations (3)
Title |
---|
CZOLLNER, L. et al.: Synthesis of new 1,5-diphenyl-3-1-H-1,2,4 triazoles substituted with H-alkyl, or carboxyl groups at C-3. Arch. Pharm., 1990, Vol. 323, pßginas 225-227. Pßgina 225, compuesto VII. * |
HOQUE, A.K.M. et al.: 1,3 dipolar cyclo additions induced by cation radicals. Formation of 1,2,4 triazoles from oxidative addition of 1,4 diphenylazomethane and aryl aldehyde phenylhydrazones to nitriles. Tetrahedron Letters, 1985, Vol. 26, nö 46, páginas 5655-5658. Compuesto 3, páginas 5655 y compuestos 1,2, página 5656. * |
Patent Abstracts of Japan [CD-ROM] & JP 08245315 A (NIPPON SODA CO LTD) 24.09.1996, resumen * |
Also Published As
Publication number | Publication date |
---|---|
AU2003215687A1 (en) | 2003-10-13 |
ES2192494B1 (es) | 2005-02-16 |
WO2003082833A1 (es) | 2003-10-09 |
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Legal Events
Date | Code | Title | Description |
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EC2A | Search report published |
Date of ref document: 20031001 Kind code of ref document: A1 |
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FD2A | Announcement of lapse in spain |
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