ES2191837T3 - Derivados de 1,2,4-triazina para la inhibicion de glicosilacion de proteinas. - Google Patents

Derivados de 1,2,4-triazina para la inhibicion de glicosilacion de proteinas.

Info

Publication number
ES2191837T3
ES2191837T3 ES97919945T ES97919945T ES2191837T3 ES 2191837 T3 ES2191837 T3 ES 2191837T3 ES 97919945 T ES97919945 T ES 97919945T ES 97919945 T ES97919945 T ES 97919945T ES 2191837 T3 ES2191837 T3 ES 2191837T3
Authority
ES
Spain
Prior art keywords
protein
glycosilation
inhibition
triazine derivatives
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97919945T
Other languages
English (en)
Spanish (es)
Inventor
Dilip R Wagle
Michael E Lankin
San-Bao Hwang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synvista Therapeutics Inc
Original Assignee
Alteon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/825,114 external-priority patent/US5932578A/en
Application filed by Alteon Inc filed Critical Alteon Inc
Application granted granted Critical
Publication of ES2191837T3 publication Critical patent/ES2191837T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
ES97919945T 1996-03-28 1997-03-28 Derivados de 1,2,4-triazina para la inhibicion de glicosilacion de proteinas. Expired - Lifetime ES2191837T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62304596A 1996-03-28 1996-03-28
US64324296A 1996-05-03 1996-05-03
US08/825,114 US5932578A (en) 1996-03-28 1997-03-27 Triazine compounds and methods of use therefor

Publications (1)

Publication Number Publication Date
ES2191837T3 true ES2191837T3 (es) 2003-09-16

Family

ID=27417336

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97919945T Expired - Lifetime ES2191837T3 (es) 1996-03-28 1997-03-28 Derivados de 1,2,4-triazina para la inhibicion de glicosilacion de proteinas.

Country Status (8)

Country Link
EP (1) EP0889884B1 (fr)
JP (1) JP2002515870A (fr)
AT (1) ATE231845T1 (fr)
AU (1) AU727846B2 (fr)
CA (1) CA2249999A1 (fr)
DE (1) DE69718775T2 (fr)
ES (1) ES2191837T3 (fr)
WO (1) WO1997035849A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036632A (en) * 1966-04-16 1977-07-19 Bayer Aktiengesellschaft Herbicidal agents
US5114943A (en) * 1984-03-19 1992-05-19 The Rockefeller University Amino-substituted pyrimidines, derivatives and methods of use therefor
US5399560A (en) * 1984-03-19 1995-03-21 The Rockefeller University 1,2,4-triazine products resulting from the inhibition of advanced glycosylation

Also Published As

Publication number Publication date
AU2425497A (en) 1997-10-17
JP2002515870A (ja) 2002-05-28
DE69718775T2 (de) 2003-10-16
DE69718775D1 (de) 2003-03-06
EP0889884A1 (fr) 1999-01-13
ATE231845T1 (de) 2003-02-15
EP0889884B1 (fr) 2003-01-29
CA2249999A1 (fr) 1997-10-02
WO1997035849A1 (fr) 1997-10-02
AU727846B2 (en) 2001-01-04

Similar Documents

Publication Publication Date Title
MX9705449A (es) Uso de compuestos de tiazolio para evitar y revertir la formacion de productos finales de glicosilacion avanzada.
ES2174132T3 (es) N-acil-a,omp-alquil-hidrazino-carboximidamidas.
ES2061435T3 (es) Procedimiento y agentes para la inhibicion del envejecimiento de las proteinas.
WO1993014750A3 (fr) Acides amines utiles comme inhibiteurs de la glycosylation avancee des proteines
EP0316852A3 (fr) Inhibiteurs du croisement non enzymatique
WO1999006545A8 (fr) Composition et nouveau procede pour depister les maladies dues a la formation d'agregats de proteines ou de fibrilles du type amyloide
EA200200262A1 (ru) Пиперазиновые производные и их применение в качестве противовоспалительных агентов
EP1128830A4 (fr) Inversion des liaisons croisees de glycosylation avancee a l'aide de sels de thiazolium a substitution heterocyclique
DK0757720T3 (da) Trimiserende polypeptider, fremstilling og anvendelse deraf
ATE227293T1 (de) 2,3-disubstituierte-(5,6)-heteroarylkondensiert - pyrimidin-4-one
RU94046295A (ru) L-аспартил-d- альфа -аминоалканоил-(s)-n-d-алкилбензиламиды, используемые в качестве искусственных подслащивающих агентов, пищевой состав, способ подслащивания пищевого состава
BR9811099A (pt) Inibidores de urocinase
BR9708460A (pt) Composto, composição farmacêutica e processo para prevenir ou tratar uma condição patológica em um humano ou animal não-humano.
ATE265409T1 (de) Von aminosauren und hydroxysauren substituierte benzamidinderivate und deren verwendung als antikoagulantien
AU5813794A (en) Aminoacid derivatives of heterocycles as protein kinase c inhibitors
LV10108A (lv) Sunu proliferacijas inhibitori farmaceitiska kompozicija savienojumu iegusanas metode sunu proliferacijas inhibesanas panemieni
ES2191837T3 (es) Derivados de 1,2,4-triazina para la inhibicion de glicosilacion de proteinas.
WO1996021450A3 (fr) Bis-(hydrazones)
AU2825897A (en) Substituted imidazolium salts and their use for the inhibition of protein ageing
WO1997042175B1 (fr) Sels d'imidazolium substitues et leur emploi pour inhiber le vieillissement de proteines
MC2042A1 (fr) Derives de propanolamine
FR2654430B1 (fr) Nouveaux derives de peptides, utilisables comme inhibiteurs des collagenases bacteriennes.
ATE204853T1 (de) Schädlingsbekämpfungsmittel
WO1998029436A3 (fr) Peptides de lebetine utilises comme inhibiteurs de l'agregation plaquettaire
MX9704733A (es) Monomeros de ciclohesan-1-ona 4,4-disubstituidos y compuestos relacionados.