ES2191678T3 - Administracion transdermica del eutomero de un farmaco quiral. - Google Patents
Administracion transdermica del eutomero de un farmaco quiral.Info
- Publication number
- ES2191678T3 ES2191678T3 ES94900579T ES94900579T ES2191678T3 ES 2191678 T3 ES2191678 T3 ES 2191678T3 ES 94900579 T ES94900579 T ES 94900579T ES 94900579 T ES94900579 T ES 94900579T ES 2191678 T3 ES2191678 T3 ES 2191678T3
- Authority
- ES
- Spain
- Prior art keywords
- eutomero
- chiral
- pharmaco
- transdermal administration
- levels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE PRESENTA UNA COMPOSICION FARMACEUTICA DEL EUTOMERO DE UN FARMACO QUIRAL CON LA QUE EL EUTOMERO TIENE UN VALOR DE SEPARACION MAYOR QUE EL DE LA MEZCLA RACEMICA DEL FARMACO QUIRAL. LAS COMPOSICIONES FARMACEUTICAS DE LA PRESENTE INVENCION PERMITEN EL SUMINISTRO DE NIVELES TERAPEUTICAMENTE EFECTIVOS DE FARMACOS A NIVELES MUCHO MAS BAJOS DE LO QUE SE NECESITARIA SI EL FARMACO FUERA SUMINISTRADO SEGUN LOS METODOS DE INYECCION CONVENCIONALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97380192A | 1992-11-09 | 1992-11-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2191678T3 true ES2191678T3 (es) | 2003-09-16 |
Family
ID=25521243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94900579T Expired - Lifetime ES2191678T3 (es) | 1992-11-09 | 1993-11-09 | Administracion transdermica del eutomero de un farmaco quiral. |
Country Status (7)
Country | Link |
---|---|
US (2) | US5883115A (es) |
EP (1) | EP0666737B1 (es) |
JP (1) | JPH08503464A (es) |
AU (1) | AU5551294A (es) |
DE (1) | DE69332669T2 (es) |
ES (1) | ES2191678T3 (es) |
WO (1) | WO1994010985A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09503997A (ja) * | 1993-07-08 | 1997-04-22 | シグナス,インコーポレイテッド | モノリシックなマトリックス経皮送達システム |
DE19642043A1 (de) * | 1995-10-23 | 1997-04-24 | Hexal Ag | Transdermales therapeutisches System (TTS) für die Verabreichung von Wirkstoffen zur Behandlung von Drogenabhängigkeit oder Drogensucht |
US5985317A (en) * | 1996-09-06 | 1999-11-16 | Theratech, Inc. | Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents |
US6365178B1 (en) * | 1996-09-06 | 2002-04-02 | Watson Pharmaceuticals, Inc. | Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions |
US6862465B2 (en) * | 1997-03-04 | 2005-03-01 | Dexcom, Inc. | Device and method for determining analyte levels |
US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
US6432203B1 (en) * | 1997-03-17 | 2002-08-13 | Applied Komatsu Technology, Inc. | Heated and cooled vacuum chamber shield |
US20050276836A1 (en) * | 1997-06-11 | 2005-12-15 | Michelle Wilson | Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents |
US6136327A (en) * | 1997-12-01 | 2000-10-24 | Alza Corporation | Stereospecific delivery of a drug using electrotransport |
US6841539B1 (en) * | 1998-05-21 | 2005-01-11 | Isis Pharmaceuticals, Inc. | Compositions and methods for topical delivery of oligonucleotides |
WO1999067645A1 (en) | 1998-06-24 | 1999-12-29 | Transderm Diagnostics, Inc. | Non-invasive transdermal detection of analytes |
WO2000024386A1 (en) * | 1998-09-08 | 2000-05-04 | Theratech, Inc. | Method of making pressure sensitive adhesive matrix patches containing hydrophilic salts of drugs |
WO2000074661A2 (en) | 1999-06-05 | 2000-12-14 | Noven Pharmaceuticals, Inc. | Solubility enhancement of drugs in transdermal drug delivery systems and methods of use |
US6905016B2 (en) * | 2000-03-14 | 2005-06-14 | Noven Pharmaceuticals, Inc. | Packaging system for transdermal drug delivery systems |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
US20040072810A1 (en) * | 2001-11-07 | 2004-04-15 | Besins International Belgique | Pharmaceutical composition in the form of a gel or a solution based on dihydrotestosterone, process for preparing it and uses thereof |
US20030149406A1 (en) * | 2002-02-07 | 2003-08-07 | Lucie Martineau | Multi-layer dressing as medical drug delivery system |
US7166641B2 (en) * | 2002-10-02 | 2007-01-23 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same |
US7132452B2 (en) * | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
US7439268B2 (en) * | 2003-07-18 | 2008-10-21 | Idexx Laboratories | Compositions containing prodrugs of florfenicol and methods of use |
WO2005011644A1 (en) * | 2003-07-28 | 2005-02-10 | Alza Corporation | Transdermal warfarin-containing delivery system |
RS20060605A (en) * | 2004-04-29 | 2008-09-29 | Caldwell Galer Inc., | Topical methadone compositions and methods for using the same |
US7402697B2 (en) * | 2004-09-02 | 2008-07-22 | Idexx Laboratories Inc. | Antibacterial agents |
CN101287470B (zh) | 2005-10-12 | 2012-10-17 | 优尼麦德药物股份有限公司 | 改良的睾酮凝胶及使用方法 |
FR2891833B1 (fr) * | 2005-10-12 | 2008-01-04 | Millet Innovation Sa | Procede de fixation d'une piece en gel polymere |
US20100010096A1 (en) * | 2006-10-27 | 2010-01-14 | John Charin Somberg | Methadone chiral isolate as an improved pharmaceutical |
US20080152592A1 (en) * | 2006-12-21 | 2008-06-26 | Bayer Healthcare Llc | Method of therapeutic drug monitoring |
WO2008115224A2 (en) * | 2007-03-20 | 2008-09-25 | Bayer Healthcare Llc | Method of analyzing an analyte |
US7550625B2 (en) * | 2007-10-19 | 2009-06-23 | Idexx Laboratories | Esters of florfenicol |
JP6150240B2 (ja) * | 2012-09-21 | 2017-06-21 | 東洋製罐株式会社 | 包装材およびそれを用いてなる包装構造 |
WO2014066653A1 (en) * | 2012-10-26 | 2014-05-01 | Allergan, Inc. | Ketorolac-containing sustained release intraocular drug delivery systems |
MX2017015623A (es) * | 2017-12-04 | 2018-11-09 | Federico Amezcua Amezcua | Novedoso compuesto quimico que contiene el enantiomero activo s-(-) ketorolaco trometamina para el tratamiento del dolor. |
WO2023278400A1 (en) * | 2021-06-30 | 2023-01-05 | University Of Padova | Modified release formulations of methadone and its isomers, esmethadone and levomethadone and derivatives |
CN116459237B (zh) * | 2023-03-29 | 2024-06-11 | 长沙晶易医药科技股份有限公司 | 一种酮咯酸贴剂组合物、酮咯酸贴剂及其制备方法 |
Family Cites Families (29)
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US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
IE54286B1 (en) * | 1983-01-18 | 1989-08-16 | Elan Corp Plc | Drug delivery device |
US4927687A (en) * | 1984-10-01 | 1990-05-22 | Biotek, Inc. | Sustained release transdermal drug delivery composition |
US4687481A (en) * | 1984-10-01 | 1987-08-18 | Biotek, Inc. | Transdermal drug delivery system |
US4624665A (en) * | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
EP0186019B1 (de) * | 1984-12-22 | 1993-10-06 | Schwarz Pharma Ag | Wirkstoffpflaster |
US5049386A (en) * | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4615699A (en) * | 1985-05-03 | 1986-10-07 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
US4690683A (en) * | 1985-07-02 | 1987-09-01 | Rutgers, The State University Of New Jersey | Transdermal varapamil delivery device |
US4940761A (en) * | 1986-05-29 | 1990-07-10 | E. I. Du Pont De Nemours And Company | Group transfer polymerization of glycidyl (meth)acrylate copolymers to form oxirane group-terminated block copolymers |
US4940586A (en) * | 1987-02-26 | 1990-07-10 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
US5114946A (en) * | 1987-06-12 | 1992-05-19 | American Cyanamid Company | Transdermal delivery of pharmaceuticals |
US4992445A (en) * | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
US4818541A (en) * | 1987-08-19 | 1989-04-04 | Schering Corporation | Transdermal delivery of enantiomers of phenylpropanolamine |
US4943435A (en) * | 1987-10-05 | 1990-07-24 | Pharmetrix Corporation | Prolonged activity nicotine patch |
US4983395A (en) * | 1987-11-12 | 1991-01-08 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
US4927854A (en) * | 1987-12-24 | 1990-05-22 | Analgesic Associates | Sustained/enhanced analgesia |
US4898734A (en) * | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
US4885154A (en) * | 1988-03-01 | 1989-12-05 | Alza Corporation | Method for reducing sensitization or irritation in transdermal drug delivery and means therefor |
US4910205A (en) * | 1988-05-02 | 1990-03-20 | Schering Corporation | Transdermal delivery of loratadine |
US5028435A (en) * | 1989-05-22 | 1991-07-02 | Advanced Polymer Systems, Inc. | System and method for transdermal drug delivery |
US5132119A (en) * | 1989-07-31 | 1992-07-21 | Massachusetts Institute Of Technology | Treatment of hypertrophic wound healing disorders with calcium channel blockers |
US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
US5069909A (en) * | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
US5091182A (en) * | 1990-07-23 | 1992-02-25 | Syntex (U.S.A.) Inc. | Dispensing units for ketorolac topical gel formlations |
GB9111732D0 (en) * | 1991-05-31 | 1991-07-24 | Orion Yhtymae Oy | The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs |
IT1250691B (it) * | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
AU669492B2 (en) * | 1991-11-11 | 1996-06-13 | Hisamitsu Pharmaceutical Co., Inc. | Fomentation containing ketorolac |
-
1993
- 1993-11-08 US US08/148,704 patent/US5883115A/en not_active Expired - Fee Related
- 1993-11-09 AU AU55512/94A patent/AU5551294A/en not_active Abandoned
- 1993-11-09 EP EP94900579A patent/EP0666737B1/en not_active Expired - Lifetime
- 1993-11-09 ES ES94900579T patent/ES2191678T3/es not_active Expired - Lifetime
- 1993-11-09 DE DE69332669T patent/DE69332669T2/de not_active Expired - Fee Related
- 1993-11-09 JP JP6512267A patent/JPH08503464A/ja active Pending
- 1993-11-09 WO PCT/US1993/010759 patent/WO1994010985A1/en active IP Right Grant
-
1995
- 1995-06-06 US US08/470,648 patent/US5589498A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0666737B1 (en) | 2003-01-29 |
US5589498A (en) | 1996-12-31 |
DE69332669T2 (de) | 2003-11-27 |
EP0666737A4 (en) | 1996-03-06 |
US5883115A (en) | 1999-03-16 |
JPH08503464A (ja) | 1996-04-16 |
EP0666737A1 (en) | 1995-08-16 |
WO1994010985A1 (en) | 1994-05-26 |
AU5551294A (en) | 1994-06-08 |
DE69332669D1 (de) | 2003-03-06 |
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