ES2191309T3 - Tratamiento de superficies metalicas para aumentar su biocompatibilidad y/o sus caracteristicas fisicas. - Google Patents

Tratamiento de superficies metalicas para aumentar su biocompatibilidad y/o sus caracteristicas fisicas.

Info

Publication number
ES2191309T3
ES2191309T3 ES98925811T ES98925811T ES2191309T3 ES 2191309 T3 ES2191309 T3 ES 2191309T3 ES 98925811 T ES98925811 T ES 98925811T ES 98925811 T ES98925811 T ES 98925811T ES 2191309 T3 ES2191309 T3 ES 2191309T3
Authority
ES
Spain
Prior art keywords
heparin
molecules
compatibility
incorporating
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98925811T
Other languages
English (en)
Inventor
Yousef Samih Taktak
Kadem Gayad Al-Lamee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polybiomed Ltd
Original Assignee
Polybiomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polybiomed Ltd filed Critical Polybiomed Ltd
Application granted granted Critical
Publication of ES2191309T3 publication Critical patent/ES2191309T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F13/00—Arrangements for modifying heat-transfer, e.g. increasing, decreasing
    • F28F13/18—Arrangements for modifying heat-transfer, e.g. increasing, decreasing by applying coatings, e.g. radiation-absorbing, radiation-reflecting; by surface treatment, e.g. polishing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Chemically Coating (AREA)
  • Prostheses (AREA)

Abstract

La invención se refiere a una superficie de metal, vidrio o cerámica tratada para mejorar su compatibilidad con materiales biológicos tales como sangre o productos relacionados con la sangre. El tratamiento implica una unión covalente de la superficie por medio de moléculas funcionalmente catalíticas, cada una de las cuales tiene al menos un grupo alcoxilano que puede formar al menos un primer enlace covalente mediante reacción con el óxido o hidróxido de dicha superficie y a menos otro grupo que pueda participar en una polimerización de radical libre. La polimerización por radical libre desde dicha molécula funcional se ve afectada entonces para construir cadenas de polímeros biocompatibles y/o hidrofílicos. La compatibilidad de la superficie metálica con materiales biológicos se puede mejorar además mediante enlaces con moléculas bioactivas tales como heparina o moléculas derivadas de la heparina con las cadenas de polímeros. Superficies metálicas adecuadas son aquellas de los dispositivos médicos tales como intercambiadores de calor, válvulas coronarias y periféricas y cables guía empleados en angioplastia.
ES98925811T 1997-06-03 1998-06-03 Tratamiento de superficies metalicas para aumentar su biocompatibilidad y/o sus caracteristicas fisicas. Expired - Lifetime ES2191309T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9711377A GB2325934A (en) 1997-06-03 1997-06-03 Treating metal surfaces to enhance bio-compatibility and/or physical characteristics

Publications (1)

Publication Number Publication Date
ES2191309T3 true ES2191309T3 (es) 2003-09-01

Family

ID=10813448

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98925811T Expired - Lifetime ES2191309T3 (es) 1997-06-03 1998-06-03 Tratamiento de superficies metalicas para aumentar su biocompatibilidad y/o sus caracteristicas fisicas.

Country Status (10)

Country Link
US (1) US6599558B1 (es)
EP (1) EP0988071B1 (es)
JP (1) JP4357005B2 (es)
AT (1) ATE233110T1 (es)
AU (1) AU740161B2 (es)
CA (1) CA2293266C (es)
DE (1) DE69811666T2 (es)
ES (1) ES2191309T3 (es)
GB (1) GB2325934A (es)
WO (1) WO1998055162A2 (es)

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Also Published As

Publication number Publication date
ATE233110T1 (de) 2003-03-15
WO1998055162A3 (en) 1999-03-04
EP0988071B1 (en) 2003-02-26
JP4357005B2 (ja) 2009-11-04
AU7778998A (en) 1998-12-21
GB2325934A (en) 1998-12-09
CA2293266C (en) 2008-08-12
WO1998055162A2 (en) 1998-12-10
JP2002502286A (ja) 2002-01-22
DE69811666D1 (de) 2003-04-03
CA2293266A1 (en) 1998-12-10
GB9711377D0 (en) 1997-07-30
AU740161B2 (en) 2001-11-01
DE69811666T2 (de) 2003-12-18
US6599558B1 (en) 2003-07-29
EP0988071A2 (en) 2000-03-29

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