ES2186734T3 - Quinazolinas como inhibidores de la enzima de conversion de la endotelina. - Google Patents
Quinazolinas como inhibidores de la enzima de conversion de la endotelina.Info
- Publication number
- ES2186734T3 ES2186734T3 ES95941477T ES95941477T ES2186734T3 ES 2186734 T3 ES2186734 T3 ES 2186734T3 ES 95941477 T ES95941477 T ES 95941477T ES 95941477 T ES95941477 T ES 95941477T ES 2186734 T3 ES2186734 T3 ES 2186734T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- endothelin
- kinazolins
- endotheline
- ischemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE DESCRIBEN NUEVAS QUINAZOLINAS INHIBIDORAS DE LA ENZIMA CONVERTIDORA DE ENDOTELINA, ASI COMO METODOS PARA LA PREPARACION Y COMPUESTOS FARMACEUTICOS DE LAS MISMAS, UTILES PARA EL TRATAMIENTO DE NIVELES ELEVADOS DE ENDOTELINA Y EN EL CONTROL DE LA HIPERTENSION, INFARTO DE MIOCARDIO E ISQUEMIA, ALTERACIONES METABOLICAS, ENDOCRINAS Y NEUROLOGICAS, INSUFICIENCIA CARDIACA CONGESTIVA, SHOCK ENDOTOXICO Y HEMORRAGICO, SHOCK SEPTICO, HEMORRAGIA SUBARACNOIDEA, ARRITMIAS, ASMA, INSUFICIENCIA RENAL AGUDA Y CRONICA, NEFROTOXICIDAD INDUCIDA POR CICLOSPORINA A, ANGINA, DAÑO DE LA MUCOSA GASTRICA, ENFERMEDAD INTESTINAL ISQUEMICA, CANCER, HIPERTENSION PULMONAR, PREECLAMPSIA, ALTERACIONES ATEROSCLEROTICAS INCLUYENDO LA ENFERMEDAD DE RAYNAUD Y RESTENOSIS, ISQUEMIA CEREBRAL Y VASOSPASMO Y DIABETES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/363,104 US5658902A (en) | 1994-12-22 | 1994-12-22 | Quinazolines as inhibitors of endothelin converting enzyme |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2186734T3 true ES2186734T3 (es) | 2003-05-16 |
Family
ID=23428818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95941477T Expired - Lifetime ES2186734T3 (es) | 1994-12-22 | 1995-11-27 | Quinazolinas como inhibidores de la enzima de conversion de la endotelina. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5658902A (es) |
EP (1) | EP0799221B1 (es) |
JP (1) | JPH10510834A (es) |
AT (1) | ATE226951T1 (es) |
CA (1) | CA2206046A1 (es) |
DE (1) | DE69528711T2 (es) |
DK (1) | DK0799221T3 (es) |
ES (1) | ES2186734T3 (es) |
PT (1) | PT799221E (es) |
SI (1) | SI0799221T1 (es) |
WO (1) | WO1996019474A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
DE19916719A1 (de) * | 1999-04-13 | 2000-10-19 | Basf Ag | Neue ECE-Inhibitoren, ihre Herstellung und Verwendung |
JP4105948B2 (ja) * | 2000-09-15 | 2008-06-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
CN1474815A (zh) * | 2000-09-20 | 2004-02-11 | Ĭ��ר���ɷ�����˾ | 4-氨基-喹唑啉 |
US7192939B2 (en) * | 2002-01-30 | 2007-03-20 | Montana State University | Pestalotiopsis microsporia isolates and compounds derived therefrom |
US7345018B2 (en) | 2002-04-25 | 2008-03-18 | Reception Aps | Method of treating side effects induced by therapeutic agents |
EA200501518A1 (ru) * | 2003-03-26 | 2006-04-28 | Ресептикон Апс | Применение соединений для профилактики лекарственно-индуцированной клеточной токсичности |
US7217794B2 (en) * | 2003-04-02 | 2007-05-15 | Daiamed, Inc. | Compounds and methods for treatment of thrombosis |
WO2005042501A1 (en) * | 2003-11-03 | 2005-05-12 | Warner-Lambert Company Llc | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders |
WO2007030582A2 (en) * | 2005-09-09 | 2007-03-15 | Bristol-Myers Squibb Company | Acyclic ikur inhibitors |
JP2017001954A (ja) * | 2013-11-08 | 2017-01-05 | 石原産業株式会社 | 含窒素飽和複素環化合物 |
WO2020214537A1 (en) * | 2019-04-15 | 2020-10-22 | Tosk, Inc. | Modulators of ras gtpase |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB857362A (en) * | 1958-12-03 | 1960-12-29 | Ici Ltd | Quinazoline derivatives |
NL265777A (es) * | 1960-06-09 | |||
US3340260A (en) * | 1962-12-03 | 1967-09-05 | Ciba Geigy Corp | 4-amino-pyrimidines |
US3301855A (en) * | 1963-04-22 | 1967-01-31 | Ciba Geigy Corp | Derivatives of 4-nu-(2-nu, nu-dimethylaminolower alkyl)-amino quinazoline |
GB1199768A (en) * | 1966-10-31 | 1970-07-22 | Pfizer & Co C | Nitrogen Heterocycles and process for their preparation |
US3470182A (en) * | 1967-02-09 | 1969-09-30 | Sandoz Ag | 4-amino-substituted quinazolines |
CH509039A (de) * | 1967-10-02 | 1971-06-30 | Ici Ltd | Handelsfähiges fungizides Mittel und Verwendung zur Bekämpfung von Pilzkrankheiten von Pflanzen |
CH578556A5 (en) * | 1973-02-20 | 1976-08-13 | Sandoz Ag | 2-(5-Nitro-heterocyclyl)-substd 4-amino-quinazolines - with bactericidal, trichomonacidal and amoebicidal activity |
SU466233A1 (ru) * | 1973-06-08 | 1975-04-05 | Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе | Способ получени производных 2-метил-4-диалкиламиноалкиламинохиназолина |
US3997538A (en) * | 1975-12-29 | 1976-12-14 | Morton-Norwich Products, Inc. | 2-(3,4-Dichlorophenyl)-4-(substituted amino)-quinazolines |
JPS542327A (en) * | 1977-06-07 | 1979-01-09 | Sankyo Co Ltd | Agricultural and horticultural pesticide |
EP0126087A1 (en) * | 1982-09-24 | 1984-11-28 | Beecham Group Plc | Amino-azabicycloalkyl derivatives as dopamine antagonists |
FR2582514B1 (fr) * | 1985-05-30 | 1988-02-19 | Rhone Poulenc Sante | Medicaments a base d'amides, nouveaux amides et leur preparation |
IL89029A (en) * | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them |
CA2032559C (en) * | 1989-12-28 | 2001-11-06 | Kiyofumi Ishikawa | Endothelin antagonistic cyclic pentapeptides |
WO1992013944A1 (en) * | 1991-02-04 | 1992-08-20 | Berlex Laboratories, Inc. | Endothelin converting enzyme |
JPH05105698A (ja) * | 1991-06-13 | 1993-04-27 | Takeda Chem Ind Ltd | ホスホン酸誘導体、その製造法および用途 |
PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
US5187168A (en) * | 1991-10-24 | 1993-02-16 | American Home Products Corporation | Substituted quinazolines as angiotensin II antagonists |
DE4208254A1 (de) * | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | 4−アミノキナゾリン誘導体およびそれを含有する医薬品 |
-
1994
- 1994-12-22 US US08/363,104 patent/US5658902A/en not_active Expired - Fee Related
-
1995
- 1995-11-27 EP EP95941477A patent/EP0799221B1/en not_active Expired - Lifetime
- 1995-11-27 PT PT95941477T patent/PT799221E/pt unknown
- 1995-11-27 AT AT95941477T patent/ATE226951T1/de not_active IP Right Cessation
- 1995-11-27 CA CA002206046A patent/CA2206046A1/en not_active Abandoned
- 1995-11-27 DE DE69528711T patent/DE69528711T2/de not_active Expired - Fee Related
- 1995-11-27 ES ES95941477T patent/ES2186734T3/es not_active Expired - Lifetime
- 1995-11-27 SI SI9530621T patent/SI0799221T1/xx unknown
- 1995-11-27 WO PCT/US1995/015366 patent/WO1996019474A1/en active IP Right Grant
- 1995-11-27 DK DK95941477T patent/DK0799221T3/da active
- 1995-11-27 JP JP8519802A patent/JPH10510834A/ja not_active Ceased
-
1997
- 1997-04-14 US US08/837,176 patent/US5773444A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69528711T2 (de) | 2003-08-14 |
PT799221E (pt) | 2003-03-31 |
US5773444A (en) | 1998-06-30 |
DE69528711D1 (de) | 2002-12-05 |
WO1996019474A1 (en) | 1996-06-27 |
CA2206046A1 (en) | 1996-06-27 |
JPH10510834A (ja) | 1998-10-20 |
EP0799221B1 (en) | 2002-10-30 |
MX9704040A (es) | 1997-09-30 |
ATE226951T1 (de) | 2002-11-15 |
EP0799221A1 (en) | 1997-10-08 |
US5658902A (en) | 1997-08-19 |
DK0799221T3 (da) | 2003-02-24 |
SI0799221T1 (en) | 2003-02-28 |
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