ES2186734T3 - Quinazolinas como inhibidores de la enzima de conversion de la endotelina. - Google Patents

Quinazolinas como inhibidores de la enzima de conversion de la endotelina.

Info

Publication number
ES2186734T3
ES2186734T3 ES95941477T ES95941477T ES2186734T3 ES 2186734 T3 ES2186734 T3 ES 2186734T3 ES 95941477 T ES95941477 T ES 95941477T ES 95941477 T ES95941477 T ES 95941477T ES 2186734 T3 ES2186734 T3 ES 2186734T3
Authority
ES
Spain
Prior art keywords
inhibitors
endothelin
kinazolins
endotheline
ischemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95941477T
Other languages
English (en)
Inventor
Kyunghye Ahn
Xue-Min Cheng
Annette Marian Doherty
Edward Faith Elslager
Brian Kornberg
Chitase Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2186734T3 publication Critical patent/ES2186734T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN NUEVAS QUINAZOLINAS INHIBIDORAS DE LA ENZIMA CONVERTIDORA DE ENDOTELINA, ASI COMO METODOS PARA LA PREPARACION Y COMPUESTOS FARMACEUTICOS DE LAS MISMAS, UTILES PARA EL TRATAMIENTO DE NIVELES ELEVADOS DE ENDOTELINA Y EN EL CONTROL DE LA HIPERTENSION, INFARTO DE MIOCARDIO E ISQUEMIA, ALTERACIONES METABOLICAS, ENDOCRINAS Y NEUROLOGICAS, INSUFICIENCIA CARDIACA CONGESTIVA, SHOCK ENDOTOXICO Y HEMORRAGICO, SHOCK SEPTICO, HEMORRAGIA SUBARACNOIDEA, ARRITMIAS, ASMA, INSUFICIENCIA RENAL AGUDA Y CRONICA, NEFROTOXICIDAD INDUCIDA POR CICLOSPORINA A, ANGINA, DAÑO DE LA MUCOSA GASTRICA, ENFERMEDAD INTESTINAL ISQUEMICA, CANCER, HIPERTENSION PULMONAR, PREECLAMPSIA, ALTERACIONES ATEROSCLEROTICAS INCLUYENDO LA ENFERMEDAD DE RAYNAUD Y RESTENOSIS, ISQUEMIA CEREBRAL Y VASOSPASMO Y DIABETES.
ES95941477T 1994-12-22 1995-11-27 Quinazolinas como inhibidores de la enzima de conversion de la endotelina. Expired - Lifetime ES2186734T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/363,104 US5658902A (en) 1994-12-22 1994-12-22 Quinazolines as inhibitors of endothelin converting enzyme

Publications (1)

Publication Number Publication Date
ES2186734T3 true ES2186734T3 (es) 2003-05-16

Family

ID=23428818

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95941477T Expired - Lifetime ES2186734T3 (es) 1994-12-22 1995-11-27 Quinazolinas como inhibidores de la enzima de conversion de la endotelina.

Country Status (11)

Country Link
US (2) US5658902A (es)
EP (1) EP0799221B1 (es)
JP (1) JPH10510834A (es)
AT (1) ATE226951T1 (es)
CA (1) CA2206046A1 (es)
DE (1) DE69528711T2 (es)
DK (1) DK0799221T3 (es)
ES (1) ES2186734T3 (es)
PT (1) PT799221E (es)
SI (1) SI0799221T1 (es)
WO (1) WO1996019474A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
DE19916719A1 (de) * 1999-04-13 2000-10-19 Basf Ag Neue ECE-Inhibitoren, ihre Herstellung und Verwendung
JP4105948B2 (ja) * 2000-09-15 2008-06-25 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼインヒビターとして有用なピラゾール化合物
CN1474815A (zh) * 2000-09-20 2004-02-11 Ĭ��ר���ɷ����޹�˾ 4-氨基-喹唑啉
US7192939B2 (en) * 2002-01-30 2007-03-20 Montana State University Pestalotiopsis microsporia isolates and compounds derived therefrom
US7345018B2 (en) 2002-04-25 2008-03-18 Reception Aps Method of treating side effects induced by therapeutic agents
EA200501518A1 (ru) * 2003-03-26 2006-04-28 Ресептикон Апс Применение соединений для профилактики лекарственно-индуцированной клеточной токсичности
US7217794B2 (en) * 2003-04-02 2007-05-15 Daiamed, Inc. Compounds and methods for treatment of thrombosis
WO2005042501A1 (en) * 2003-11-03 2005-05-12 Warner-Lambert Company Llc Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders
WO2007030582A2 (en) * 2005-09-09 2007-03-15 Bristol-Myers Squibb Company Acyclic ikur inhibitors
JP2017001954A (ja) * 2013-11-08 2017-01-05 石原産業株式会社 含窒素飽和複素環化合物
WO2020214537A1 (en) * 2019-04-15 2020-10-22 Tosk, Inc. Modulators of ras gtpase

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB857362A (en) * 1958-12-03 1960-12-29 Ici Ltd Quinazoline derivatives
NL265777A (es) * 1960-06-09
US3340260A (en) * 1962-12-03 1967-09-05 Ciba Geigy Corp 4-amino-pyrimidines
US3301855A (en) * 1963-04-22 1967-01-31 Ciba Geigy Corp Derivatives of 4-nu-(2-nu, nu-dimethylaminolower alkyl)-amino quinazoline
GB1199768A (en) * 1966-10-31 1970-07-22 Pfizer & Co C Nitrogen Heterocycles and process for their preparation
US3470182A (en) * 1967-02-09 1969-09-30 Sandoz Ag 4-amino-substituted quinazolines
CH509039A (de) * 1967-10-02 1971-06-30 Ici Ltd Handelsfähiges fungizides Mittel und Verwendung zur Bekämpfung von Pilzkrankheiten von Pflanzen
CH578556A5 (en) * 1973-02-20 1976-08-13 Sandoz Ag 2-(5-Nitro-heterocyclyl)-substd 4-amino-quinazolines - with bactericidal, trichomonacidal and amoebicidal activity
SU466233A1 (ru) * 1973-06-08 1975-04-05 Всесоюзный научно-исследовательский химико-фармацевтический институт им. С.Орджоникидзе Способ получени производных 2-метил-4-диалкиламиноалкиламинохиназолина
US3997538A (en) * 1975-12-29 1976-12-14 Morton-Norwich Products, Inc. 2-(3,4-Dichlorophenyl)-4-(substituted amino)-quinazolines
JPS542327A (en) * 1977-06-07 1979-01-09 Sankyo Co Ltd Agricultural and horticultural pesticide
EP0126087A1 (en) * 1982-09-24 1984-11-28 Beecham Group Plc Amino-azabicycloalkyl derivatives as dopamine antagonists
FR2582514B1 (fr) * 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation
IL89029A (en) * 1988-01-29 1993-01-31 Lilly Co Eli Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
WO1992013944A1 (en) * 1991-02-04 1992-08-20 Berlex Laboratories, Inc. Endothelin converting enzyme
JPH05105698A (ja) * 1991-06-13 1993-04-27 Takeda Chem Ind Ltd ホスホン酸誘導体、その製造法および用途
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US5187168A (en) * 1991-10-24 1993-02-16 American Home Products Corporation Substituted quinazolines as angiotensin II antagonists
DE4208254A1 (de) * 1992-03-14 1993-09-16 Hoechst Ag Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品

Also Published As

Publication number Publication date
DE69528711T2 (de) 2003-08-14
PT799221E (pt) 2003-03-31
US5773444A (en) 1998-06-30
DE69528711D1 (de) 2002-12-05
WO1996019474A1 (en) 1996-06-27
CA2206046A1 (en) 1996-06-27
JPH10510834A (ja) 1998-10-20
EP0799221B1 (en) 2002-10-30
MX9704040A (es) 1997-09-30
ATE226951T1 (de) 2002-11-15
EP0799221A1 (en) 1997-10-08
US5658902A (en) 1997-08-19
DK0799221T3 (da) 2003-02-24
SI0799221T1 (en) 2003-02-28

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