ES2185042T3 - Inhibidores de la trombina. - Google Patents

Inhibidores de la trombina.

Info

Publication number
ES2185042T3
ES2185042T3 ES97937175T ES97937175T ES2185042T3 ES 2185042 T3 ES2185042 T3 ES 2185042T3 ES 97937175 T ES97937175 T ES 97937175T ES 97937175 T ES97937175 T ES 97937175T ES 2185042 T3 ES2185042 T3 ES 2185042T3
Authority
ES
Spain
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97937175T
Other languages
English (en)
Spanish (es)
Inventor
Mark E Fraley
Randall W Hungate
Adel M Naylor-Olsen
Joseph P Vacca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625311.7A external-priority patent/GB9625311D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2185042T3 publication Critical patent/ES2185042T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
ES97937175T 1996-08-12 1997-08-08 Inhibidores de la trombina. Expired - Lifetime ES2185042T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2382996P 1996-08-12 1996-08-12
GBGB9625311.7A GB9625311D0 (en) 1996-12-05 1996-12-05 Thrombin inhibitors

Publications (1)

Publication Number Publication Date
ES2185042T3 true ES2185042T3 (es) 2003-04-16

Family

ID=26310558

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97937175T Expired - Lifetime ES2185042T3 (es) 1996-08-12 1997-08-08 Inhibidores de la trombina.

Country Status (8)

Country Link
EP (1) EP0949921B1 (enExample)
JP (1) JP2000516929A (enExample)
AT (1) ATE227571T1 (enExample)
AU (1) AU713527B2 (enExample)
CA (1) CA2262686A1 (enExample)
DE (1) DE69717147T2 (enExample)
ES (1) ES2185042T3 (enExample)
WO (1) WO1998006396A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2696009C (en) 2007-08-24 2016-08-02 Marinomed Biotechnologie Gmbh Antiviral composition comprising a sulfated polysaccharide
JP6479749B2 (ja) * 2013-03-15 2019-03-06 ヴァーセオン コーポレイション トロンビン阻害剤としてのハロゲノピラゾール

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6013788A (ja) * 1983-07-05 1985-01-24 Yamanouchi Pharmaceut Co Ltd 新規なクマリン誘導体
EP0446604A3 (en) * 1990-03-16 1992-02-19 American Cyanamid Company Pyridine and related aza heterocycle derivatives as cardiovascular agents
MX9100513A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
WO1992008709A1 (de) * 1990-11-15 1992-05-29 Pentapharm Ag Meta-substituierte phenylalanin-derivate
US5399564A (en) * 1991-09-03 1995-03-21 Dowelanco N-(4-pyridyl or 4-quinolinyl) arylacetamide and 4-(aralkoxy or aralkylamino) pyridine pesticides
FR2695387B1 (fr) * 1992-09-09 1994-10-21 Adir Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6506876B1 (en) * 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use

Also Published As

Publication number Publication date
ATE227571T1 (de) 2002-11-15
WO1998006396A1 (en) 1998-02-19
AU3974997A (en) 1998-03-06
EP0949921A1 (en) 1999-10-20
CA2262686A1 (en) 1998-02-19
AU713527B2 (en) 1999-12-02
EP0949921A4 (enExample) 1999-10-20
DE69717147T2 (de) 2003-07-24
DE69717147D1 (en) 2002-12-19
JP2000516929A (ja) 2000-12-19
EP0949921B1 (en) 2002-11-13

Similar Documents

Publication Publication Date Title
ES2191830T3 (es) Inhibidores de trombina.
NO984928L (no) Pyrazinontrombininhibitorer
PT892780E (pt) Analogos de m-amidino fenilo como inibidores do factor xa
ATE227274T1 (de) 1,3-diheterozyklische metalloprotease inhibitoren
ID18142A (id) Inhibitor metaloprotease 1,4-heterosiklik
DE60010098D1 (de) 28-epirapaloge
PT1109812E (pt) Pirrolobenzodiazepinas
TR199900310T2 (xx) Trombin inhibit�rleri
DK1114032T3 (da) 4-aminosubstituerede-2-substituerede-1,2,3,4-tetrahydroquinoliner som CETB-inhibitorer
EP0760658A4 (en) PREPARATIONS FOR INHIBITING BONE RESORPTION BROUGHT BY OSTEOCLASTIC
DZ2285A1 (fr) Inhibiteurs de protéase de la cystéine.
NO994877L (no) Kalsilytiske forbindelser
ID16104A (id) Inhibitor-inhibitor serin protease.
ES2186807T3 (es) Inhibidores de trombina.
TR200003859T2 (tr) Amidino ve guanidino azetidinon triptaz önleyicileri
NO990849L (no) Substituerte 1,2,3,4-tetrahydro-2-dibenzofuranaminer og 2-aminocyklohepta (b) benzofuraner
BG100248A (bg) Инхибитори на скваленсинтетаза
ES2185042T3 (es) Inhibidores de la trombina.
YU48719B (sh) Lizin so 6-hloro-5-fluoro-3-(2-tenoil)-2-oksindol-1-karboksamida
UY24326A1 (es) Nuevas piperidinas.
TR199801087T2 (xx) 4,10 �- diasetoksi-2alfa-Benzoiloksi- 5 �, 20 epoksi-1- hidroksi-9- okso-19- norsiklopropa(G) taks-11- en- 13alfa-il