ATE227571T1 - Thrombin inhibitoren - Google Patents

Thrombin inhibitoren

Info

Publication number
ATE227571T1
ATE227571T1 AT97937175T AT97937175T ATE227571T1 AT E227571 T1 ATE227571 T1 AT E227571T1 AT 97937175 T AT97937175 T AT 97937175T AT 97937175 T AT97937175 T AT 97937175T AT E227571 T1 ATE227571 T1 AT E227571T1
Authority
AT
Austria
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
compound
formula
Prior art date
Application number
AT97937175T
Other languages
German (de)
English (en)
Inventor
Mark E Fraley
Randall W Hungate
Adel M Naylor-Olsen
Joseph P Vacca
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625311.7A external-priority patent/GB9625311D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE227571T1 publication Critical patent/ATE227571T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
AT97937175T 1996-08-12 1997-08-08 Thrombin inhibitoren ATE227571T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2382996P 1996-08-12 1996-08-12
GBGB9625311.7A GB9625311D0 (en) 1996-12-05 1996-12-05 Thrombin inhibitors
PCT/US1997/014019 WO1998006396A1 (en) 1996-08-12 1997-08-08 Thrombin inhibitors

Publications (1)

Publication Number Publication Date
ATE227571T1 true ATE227571T1 (de) 2002-11-15

Family

ID=26310558

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97937175T ATE227571T1 (de) 1996-08-12 1997-08-08 Thrombin inhibitoren

Country Status (8)

Country Link
EP (1) EP0949921B1 (enExample)
JP (1) JP2000516929A (enExample)
AT (1) ATE227571T1 (enExample)
AU (1) AU713527B2 (enExample)
CA (1) CA2262686A1 (enExample)
DE (1) DE69717147T2 (enExample)
ES (1) ES2185042T3 (enExample)
WO (1) WO1998006396A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2406684T3 (es) 2007-08-24 2013-06-07 Marinomed Biotechnologie Gmbh Composición antiviral que comprende un polisacárido sulfatado: iota carragenano
BR112015023214A8 (pt) * 2013-03-15 2019-12-24 Verseon Corp composto, composição farmacêutica, e, uso de um composto ou composição farmacêutica

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6013788A (ja) * 1983-07-05 1985-01-24 Yamanouchi Pharmaceut Co Ltd 新規なクマリン誘導体
EP0446604A3 (en) * 1990-03-16 1992-02-19 American Cyanamid Company Pyridine and related aza heterocycle derivatives as cardiovascular agents
IE912759A1 (en) * 1990-08-06 1992-02-12 Smith Kline French Lab Compounds
WO1992008709A1 (de) * 1990-11-15 1992-05-29 Pentapharm Ag Meta-substituierte phenylalanin-derivate
US5399564A (en) * 1991-09-03 1995-03-21 Dowelanco N-(4-pyridyl or 4-quinolinyl) arylacetamide and 4-(aralkoxy or aralkylamino) pyridine pesticides
FR2695387B1 (fr) * 1992-09-09 1994-10-21 Adir Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6506876B1 (en) * 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use

Also Published As

Publication number Publication date
EP0949921B1 (en) 2002-11-13
JP2000516929A (ja) 2000-12-19
ES2185042T3 (es) 2003-04-16
CA2262686A1 (en) 1998-02-19
EP0949921A1 (en) 1999-10-20
AU713527B2 (en) 1999-12-02
DE69717147D1 (en) 2002-12-19
DE69717147T2 (de) 2003-07-24
WO1998006396A1 (en) 1998-02-19
AU3974997A (en) 1998-03-06
EP0949921A4 (enExample) 1999-10-20

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties