ES2183714B1 - A PROCEDURE FOR THE MANUFACTURE OF OXALATE (1R, 2R-CYCLHEXANODIAMINE) -PLATINO (II). - Google Patents

A PROCEDURE FOR THE MANUFACTURE OF OXALATE (1R, 2R-CYCLHEXANODIAMINE) -PLATINO (II).

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Publication number
ES2183714B1
ES2183714B1 ES200101213A ES200101213A ES2183714B1 ES 2183714 B1 ES2183714 B1 ES 2183714B1 ES 200101213 A ES200101213 A ES 200101213A ES 200101213 A ES200101213 A ES 200101213A ES 2183714 B1 ES2183714 B1 ES 2183714B1
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ES
Spain
Prior art keywords
aqueous solution
oxalate
cyclohexanediamine
platinum
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200101213A
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Spanish (es)
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ES2183714A1 (en
Inventor
Carlos Gaozza
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DESYNTH S A
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DESYNTH S A
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Publication date
Application filed by DESYNTH S A filed Critical DESYNTH S A
Priority to ES200101213A priority Critical patent/ES2183714B1/en
Publication of ES2183714A1 publication Critical patent/ES2183714A1/en
Application granted granted Critical
Publication of ES2183714B1 publication Critical patent/ES2183714B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un procedimiento para la fabricación de oxalato de (1R, 2R- ciclohexanodiamina)-platino (II) que consiste en proceder según las siguientes etapas. a- Tratar una solución acuosa de una sal neutra de elevada pureza óptica de (1R, 2R)- ciclohexanodiamina, b- La solución acuosa resultante de la etapa "a" se mezcla con una solución acuosa de tetraiodoplatinito de potasio(I{sub,4} PtK {sub,2}), obteniéndose(1R, 2R)- ciclohexanodiaminadiiodoplatino (II) (compuesto D) que precipita y se separa por filtración. c- El compuesto D se suspende en agua destilada apirógena y se trata con una solución acuosa de nitrato de plata obtenida empleando agua destilada apirógena, calentando y agitando durante todo el tiempo necesario para transformar todo el iodo del compuesto D en ioduro de plata. La mezcla resultante se enfría y se filtra. d- A la solución acuosa de nitrato de (1R, 2R)-ciclohexanodiamindiacuoplatino (II) se le agrega, un exceso de solución acuosa de oxalato de potasio, cristalizando el productofinal, oxalato (1R, 2R-ciclohexanodiamina) platino (II), e- Separar el oxalato de (1R, 2R-ciclohexanodiamina) platino (II) cristalizado en la etapa (d). El producto fabricado mediante el procedimiento de la presente invención tiene aplicación terapéutica oncológica y está especialmente indicado para el tratamiento de blastomas sólidos tales como el de colón.A process for the manufacture of (1R, 2R-cyclohexanediamine) -platinum (II) oxalate which consists in proceeding according to the following steps. a- Treat an aqueous solution of a neutral salt of high optical purity of (1R, 2R) -cyclohexanediamine, b- The aqueous solution resulting from step "a" is mixed with an aqueous solution of potassium tetraiodoplatinite (I {sub, 4} PtK {sub, 2}), obtaining (1R, 2R) -cyclohexanedianediiodoplatin (II) (compound D) that precipitates and is filtered off. c- Compound D is suspended in pyrogenic distilled water and treated with an aqueous solution of silver nitrate obtained using distilled distilled water, heating and stirring for the entire time necessary to transform the entire iodine of compound D into silver iodide. The resulting mixture is cooled and filtered. d- To the aqueous solution of nitrate of (1R, 2R) -cyclohexanodiamindiacuoplatin (II) is added, an excess of aqueous solution of potassium oxalate, crystallizing the final product, oxalate (1R, 2R-cyclohexanediamine) platinum (II), e- Separate the (1R, 2R-cyclohexanediamine) platinum (II) oxalate crystallized in step (d). The product manufactured by the process of the present invention has an oncological therapeutic application and is especially suitable for the treatment of solid blastomas such as that of colon.

ES200101213A 2001-05-25 2001-05-25 A PROCEDURE FOR THE MANUFACTURE OF OXALATE (1R, 2R-CYCLHEXANODIAMINE) -PLATINO (II). Expired - Fee Related ES2183714B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES200101213A ES2183714B1 (en) 2001-05-25 2001-05-25 A PROCEDURE FOR THE MANUFACTURE OF OXALATE (1R, 2R-CYCLHEXANODIAMINE) -PLATINO (II).

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101213A ES2183714B1 (en) 2001-05-25 2001-05-25 A PROCEDURE FOR THE MANUFACTURE OF OXALATE (1R, 2R-CYCLHEXANODIAMINE) -PLATINO (II).

Publications (2)

Publication Number Publication Date
ES2183714A1 ES2183714A1 (en) 2003-03-16
ES2183714B1 true ES2183714B1 (en) 2004-01-16

Family

ID=8497855

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200101213A Expired - Fee Related ES2183714B1 (en) 2001-05-25 2001-05-25 A PROCEDURE FOR THE MANUFACTURE OF OXALATE (1R, 2R-CYCLHEXANODIAMINE) -PLATINO (II).

Country Status (1)

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ES (1) ES2183714B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR072238A1 (en) * 2009-01-13 2010-08-18 Eriochem Sa PROCESS TO PREPARE NEUTRAL ANATYNOPLASIC DERIVATIVES OF PLATINUM (II) PHARMACEUTICAL DEGREE WITH LOW SILVER CONTENT
EP2208731B1 (en) 2009-06-26 2012-08-15 Umicore AG & Co. KG Process for preparation of 1,2-diamino-cyclohexane-platinum(II) complexes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0776230B2 (en) * 1992-01-13 1995-08-16 田中貴金属工業株式会社 Method for producing platinum compound
JPH06287021A (en) * 1992-04-22 1994-10-11 Tanaka Kikinzoku Kogyo Kk Optical resolution of optically active platinum complex compound
JP3025602B2 (en) * 1993-05-21 2000-03-27 デビオファーム エス．アー． Method for producing optically high purity cis-oxalate (trans-l-l, 2-cyclohexanediamine) platinum (II) complex

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Publication number Publication date
ES2183714A1 (en) 2003-03-16

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