ES2181601A1 - Derivados de acido araquidonico con afinidad por el transportador de anandamida - Google Patents
Derivados de acido araquidonico con afinidad por el transportador de anandamidaInfo
- Publication number
- ES2181601A1 ES2181601A1 ES200101769A ES200101769A ES2181601A1 ES 2181601 A1 ES2181601 A1 ES 2181601A1 ES 200101769 A ES200101769 A ES 200101769A ES 200101769 A ES200101769 A ES 200101769A ES 2181601 A1 ES2181601 A1 ES 2181601A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- acid derivatives
- arachidonic acid
- tumors
- neurodegenerative diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a los compuestos derivados de ácido araquidónico de fórmula general I, así como a sus estereoisómeros y sus mezclas, y las sales y solvatos farmacéuticamente aceptables de todos ellos. También se describe un procedimiento para la preparación de los compuestos mencionados, la caracterización farmacológica y las aplicaciones terapéuticas. **FIGURA** En donde: X representa CO, CS o CH{sub, 2} Y representa CH{sub, 2}, O, S, NH, o NR (R representa alquilo, alquilarilo o arilo) Z representa H o un grupo alquilo, alquilarilo o arilo Heterociclo representa una subunidad monocíclica aromática o una subunidad monocíclica alifática constituida por uno o dos heteroátomos y unidades metilénicas o los derivados benzofusionados de ambas subunidades.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/ES2001/000305 WO2002012167A1 (es) | 2000-07-28 | 2001-07-27 | Derivados de acido araquidonico con afinidad por el transportador de anandamida |
AU2001284061A AU2001284061A1 (en) | 2000-07-28 | 2001-07-27 | Novel araquidonic acid derivatives with affinity toward the anandamide transporter |
ES200101769A ES2181601B2 (es) | 2001-07-27 | 2001-07-27 | Derivados de acido araquidonico con afinidad por el transportador de anandamida |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200101769A ES2181601B2 (es) | 2001-07-27 | 2001-07-27 | Derivados de acido araquidonico con afinidad por el transportador de anandamida |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2181601A1 true ES2181601A1 (es) | 2003-02-16 |
ES2181601B2 ES2181601B2 (es) | 2004-04-01 |
Family
ID=8498544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200101769A Expired - Lifetime ES2181601B2 (es) | 2000-07-28 | 2001-07-27 | Derivados de acido araquidonico con afinidad por el transportador de anandamida |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2181601B2 (es) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997045407A1 (en) * | 1996-05-31 | 1997-12-04 | University Of Connecticut | Novel anandamide amidase inhibitors as analgesic agents |
WO1999064389A1 (en) * | 1998-06-09 | 1999-12-16 | Alexandros Makriyannis | Inhibitors of the anandamide transporter as analgesic agents |
WO2000032200A1 (en) * | 1998-11-24 | 2000-06-08 | Alexandros Makriyannis | Cannabimimetic lipid amides as useful medications |
WO2001028498A2 (en) * | 1999-10-18 | 2001-04-26 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
-
2001
- 2001-07-27 ES ES200101769A patent/ES2181601B2/es not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997045407A1 (en) * | 1996-05-31 | 1997-12-04 | University Of Connecticut | Novel anandamide amidase inhibitors as analgesic agents |
WO1999064389A1 (en) * | 1998-06-09 | 1999-12-16 | Alexandros Makriyannis | Inhibitors of the anandamide transporter as analgesic agents |
WO2000032200A1 (en) * | 1998-11-24 | 2000-06-08 | Alexandros Makriyannis | Cannabimimetic lipid amides as useful medications |
WO2001028498A2 (en) * | 1999-10-18 | 2001-04-26 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
Non-Patent Citations (1)
Title |
---|
BASE DE DATOS CAPLUS en STN, AN 1999:314488 & Proc. Nat. Acad. Sci., USA, 1999, Vol. 96, pßginas 5802-5807. D. PIOMELLI et al. "Structural determinants for recognition and translocation by the anandamide transporter". Resumen. * |
Also Published As
Publication number | Publication date |
---|---|
ES2181601B2 (es) | 2004-04-01 |
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