ES2179550T3 - 15-metil-ciclopropanoesteroides y proceso para su preparacion. - Google Patents

15-metil-ciclopropanoesteroides y proceso para su preparacion.

Info

Publication number
ES2179550T3
ES2179550T3 ES98965592T ES98965592T ES2179550T3 ES 2179550 T3 ES2179550 T3 ES 2179550T3 ES 98965592 T ES98965592 T ES 98965592T ES 98965592 T ES98965592 T ES 98965592T ES 2179550 T3 ES2179550 T3 ES 2179550T3
Authority
ES
Spain
Prior art keywords
methyl
group
cyclopropanosteroids
hydrogen atom
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98965592T
Other languages
English (en)
Inventor
Sigfrid Schwarz
Walter Elger
Gunter Kaufmann
Wolfgang Romer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jenapharm GmbH and Co KG
Original Assignee
Jenapharm GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm GmbH and Co KG filed Critical Jenapharm GmbH and Co KG
Application granted granted Critical
Publication of ES2179550T3 publication Critical patent/ES2179550T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

15-metil-ciclopropanoesteroides de la fórmula general I, en la cual R1 significa un átomo de hidrógeno, un grupo alquilo, un grupo acilo o un grupo sulfamoílo, R2 y R3, independientemente uno de otro, significan un átomo de hidrógeno o un átomo de halógeno, R4 representa un grupo oxo o un átomo de hidrógeno y un grupo hidroxi, y el grupo 14,15-metileno presenta configuración á o â, donde el grupo 15-metilo está en posición â, cuando el grupo 14,15-metileno está dispuesto en á, y viceversa.
ES98965592T 1997-12-02 1998-11-30 15-metil-ciclopropanoesteroides y proceso para su preparacion. Expired - Lifetime ES2179550T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19753363A DE19753363A1 (de) 1997-12-02 1997-12-02 15-Methyl-cyclopropanosteroide und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ES2179550T3 true ES2179550T3 (es) 2003-01-16

Family

ID=7850458

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98965592T Expired - Lifetime ES2179550T3 (es) 1997-12-02 1998-11-30 15-metil-ciclopropanoesteroides y proceso para su preparacion.

Country Status (9)

Country Link
EP (1) EP1056769B1 (es)
JP (1) JP2001525334A (es)
AT (1) ATE219497T1 (es)
AU (1) AU2148899A (es)
DE (2) DE19753363A1 (es)
DK (1) DK1056769T3 (es)
ES (1) ES2179550T3 (es)
PT (1) PT1056769E (es)
WO (1) WO1999028337A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766224A (en) * 1971-06-03 1973-10-16 Sandoz Ag 15-methyl-substituted steroids
DE4239945C2 (de) * 1992-11-27 2002-11-28 Jenapharm Gmbh 14 alpha, 15 alpha-Methylensteroide und Verfahren zu ihrer Herstellung
DE4239946C2 (de) * 1992-11-27 2001-09-13 Jenapharm Gmbh Estranderivate mit einer 14alpha,15alpha-Methylengruppe und Verfahren zu ihrer Herstellung
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie

Also Published As

Publication number Publication date
DE59804539D1 (de) 2002-07-25
EP1056769A1 (de) 2000-12-06
EP1056769B1 (de) 2002-06-19
DK1056769T3 (da) 2002-10-14
DE19753363A1 (de) 1999-06-10
AU2148899A (en) 1999-06-16
PT1056769E (pt) 2002-11-29
ATE219497T1 (de) 2002-07-15
JP2001525334A (ja) 2001-12-11
WO1999028337A1 (de) 1999-06-10

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