ES2175930T3 - Procedimiento de preparacion de poliazacicloalcano inmovilizado sobre gel de silice y uso de compuestos inmovilizados. - Google Patents
Procedimiento de preparacion de poliazacicloalcano inmovilizado sobre gel de silice y uso de compuestos inmovilizados.Info
- Publication number
- ES2175930T3 ES2175930T3 ES99900983T ES99900983T ES2175930T3 ES 2175930 T3 ES2175930 T3 ES 2175930T3 ES 99900983 T ES99900983 T ES 99900983T ES 99900983 T ES99900983 T ES 99900983T ES 2175930 T3 ES2175930 T3 ES 2175930T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- carbon atoms
- radical
- alkyl radical
- immobilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- -1 alkyl radical Chemical class 0.000 abstract 10
- 125000004432 carbon atom Chemical group C* 0.000 abstract 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000003254 radicals Chemical class 0.000 abstract 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 4
- 239000000741 silica gel Substances 0.000 abstract 4
- 229910002027 silica gel Inorganic materials 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 abstract 2
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 abstract 2
- KRTGJZMJJVEKRX-UHFFFAOYSA-N 2-phenylethan-1-yl Chemical compound [CH2]CC1=CC=CC=C1 KRTGJZMJJVEKRX-UHFFFAOYSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000732 arylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
- B01J20/3263—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. an heterocyclic or heteroaromatic structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
- B01J20/3259—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J45/00—Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Catalysts (AREA)
- Silicon Polymers (AREA)
Abstract
Procedimiento de preparación de un poliazacicloalcano inmovilizado sobre gel de sílice, a partir de un poliazacicloalcano de fórmula (A): **formula** (A) en la cual R1 y R2, iguales o diferentes, representan cada uno independientemente uno de otro un átomo de hidrógeno, un radical alquilo, lineal o ramificado, que comprende de 1 a 15 átomos de carbono o un radical [hetero(aril)]alquilo que comprende de 7 a 12 átomos de carbono, W1, W2 y W3, iguales o diferentes, representan independientemente uno de otro un radical divalente escogido entre los representados por la fórmula general (B): -[(CT1T2)n-[N(R3)]p-(CT3T4)m]l(B) en la cual p representa un número entero igual a 1 o igual a 0, l representa un número entero igual a 1 ó 2, n y m, iguales o diferentes, representan cada uno independientemente uno de otro un número entero inferior o igual a 3 y superior o igual a 1, T1, T2, T3 y T4, iguales o diferentes, representan o bien cada uno independientemente uno de otro un átomo de hidrógeno, un radical alquilo, lineal o ramificado, que comprende de 1 a 15 átomos de carbono, o un radical [hetero(aril)]alquilo que comprende de 7 a 12 átomos de carbono, o bien CT1T2 y/o CT3T4 representan el grupo divalente -(C=O)-, R3 representa, independientemente de R1 o R2, unátomo de hidrógeno, un radical alquilo, lineal o ramificado, que comprende de 1 a 15 átomos de carbono, o un radical [hetero(aril)]alquilo que comprende de 7 a 12 átomos de carbono, debiendo entenderse que el núcleo de poliazacicloalcano del compuesto de fórmula (A) comprende como máximo 30 átomos de carbono cíclicos, y como máximo 6 átomos de nitrógeno cíclicos, caracterizado porque: a) el compuesto de fórmula (A) se hace reaccionar con un compuesto de fórmula (C) Z-R4-Si(X1)(X2)(X3) (C) en la cual: X1, X2 y X3, iguales o diferentes, representan cada uno independientemente uno de otro un átomo de hidrógeno, un átomo de halógeno o un radical OR5, en el que R5 representa un átomo de hidrógeno o un radical alquilo que comprende de1 a 4 átomos de carbono, R4 representa un radical divalente derivado de una cadena hidrocarbonada alifática saturada o insaturada que comprende de 1 a 10 átomos de carbono, en la que están eventualmente intercalados uno o varios eslabones estructurales escogidos entre el grupo arileno, o los fragmentos -O-, -S-, -O-C(=O)-, -N(R6)-C(=O)o -N(R6)-, en los que R6 representa un átomo de hidrógeno, un radical hidrocarbonado alifático que comprende de 1 a 6 átomos de carbono, un radical bencilo o un radical fenetilo, estando no sustituida o sustituida dicha cadena con uno o varios radicales escogidos entre átomos de halógenos, un grupo hidroxi, radicales alquilo que comprenden de 1 a 4 átomos de carbono o radicales bencilo o fenetilo, y Z representa un grupo funcional capaz de reaccionar con la función de amina secundaria, =N-H, para formar un enlace covalente N-C, para formar un compuesto de fórmula (D) **fórmula** (D) en la que R''4 representa o bien R4, como se definió anteriormente, o bien R4sustituido con un radical procedente de la reacción de Z con el grupo de amina secundaria =N-H, b) dicho compuesto de fórmula (D) es condensado sobre sitios de silanol de un gel de sílice, para formar el poliazacicloalcano inmovilizado de fórmula (E) :**fórmula** (E) en la cual: X''2 representa X2, como se denió anteriormente, o O-(gel de sílice), y X''3 representa X3, como se denió anteriormente, o O-(gel de sílice); c) y ciertos sitios de silanol que no han reaccionado son protegidos, si se desea, por Z'', un grupo protector de la función hidroxilo, para formar el poliazacicloalcano inmovilizado de fórmula (E''), correspondientea la fórmula (E) en la que todos o parte de los sitios -OH libres del gel de sílice están bloqueados en la forma del sitio OZ'' y, particularmente, en formas de sitios (trialquil)sililoxi.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9800784A FR2774092B1 (fr) | 1998-01-26 | 1998-01-26 | Procede de preparation de polyazacycloalcanes greffes sur gel de silice et utilisation des composes greffes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175930T3 true ES2175930T3 (es) | 2002-11-16 |
Family
ID=9522149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99900983T Expired - Lifetime ES2175930T3 (es) | 1998-01-26 | 1999-01-22 | Procedimiento de preparacion de poliazacicloalcano inmovilizado sobre gel de silice y uso de compuestos inmovilizados. |
Country Status (6)
Country | Link |
---|---|
US (1) | US6372903B1 (es) |
EP (1) | EP1051257B1 (es) |
DE (1) | DE69901161T2 (es) |
ES (1) | ES2175930T3 (es) |
FR (1) | FR2774092B1 (es) |
WO (1) | WO1999037399A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2774093B1 (fr) * | 1998-01-26 | 2000-03-17 | Air Liquide | Nouveau gel de silice incorporant des motifs polyazacycloalcanes, procede de preparation et utilisation |
FR2789380B1 (fr) * | 1999-02-09 | 2001-03-09 | Air Liquide | Procede d'epuration du peroxyde d'hydrogene utilisant un support mineral modifie |
FR2796645B1 (fr) | 1999-07-23 | 2001-09-14 | Air Liquide | Nouveau gel de silice incorporant des motifs polyazacycloalcanes comportant plus de six atomes d'azote, procede de preparation et utilisation |
US7504364B2 (en) * | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
FR2911340B1 (fr) * | 2007-01-16 | 2009-04-17 | Commissariat Energie Atomique | Materiau comprenant des polyazacycloalcanes, greffes sur des fibres de polypropylene, son procede de preparation, et procede d'elimination de cations metalliques d'un liquide |
US8969353B2 (en) | 2008-11-07 | 2015-03-03 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
WO2012027727A2 (en) * | 2010-08-26 | 2012-03-01 | Kunyuan Cui | Lipomacrocycles and uses thereof |
CA2831392C (en) * | 2011-03-28 | 2020-04-28 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
NZ747501A (en) | 2011-10-27 | 2020-05-29 | Massachusetts Inst Technology | Amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres |
WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
RS64331B1 (sr) | 2015-06-19 | 2023-08-31 | Massachusetts Inst Technology | Alkenil supstituisani 2,5-piperazindioni i njihova primena u sastavima za isporuku agensa u organizam ili ćeliju subjekta |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2803528C2 (de) * | 1977-03-09 | 1984-10-18 | Tabushi, Iwao, Kyoto | Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen |
EP0117324B1 (en) * | 1983-02-18 | 1986-09-17 | Dow Corning Corporation | Metal extraction from solution and immobilized chelating agents used therefor |
US5120443A (en) * | 1991-06-03 | 1992-06-09 | Brigham Young University | Processes for removing, separating and concentrating rhodium, iridium, and ruthenium from solutions using macrocyclic and nonmacrocyclic polyalkylene-polyamine-containing ligands bonded to inorganic supports |
FR2725382B1 (fr) * | 1994-10-05 | 1997-01-03 | Commissariat Energie Atomique | Polyazacycloalcanes, complexes tri-, tetra- ou pentaazamacrocycliques, procede de fabrication de ces polyazacycloalcanes substitues ou non et greffes sur un support et utilisations des polyazacycloalcanes |
FR2789380B1 (fr) * | 1999-02-09 | 2001-03-09 | Air Liquide | Procede d'epuration du peroxyde d'hydrogene utilisant un support mineral modifie |
-
1998
- 1998-01-26 FR FR9800784A patent/FR2774092B1/fr not_active Expired - Fee Related
-
1999
- 1999-01-22 EP EP99900983A patent/EP1051257B1/fr not_active Expired - Lifetime
- 1999-01-22 US US09/600,996 patent/US6372903B1/en not_active Expired - Fee Related
- 1999-01-22 DE DE69901161T patent/DE69901161T2/de not_active Expired - Lifetime
- 1999-01-22 WO PCT/FR1999/000127 patent/WO1999037399A1/fr active IP Right Grant
- 1999-01-22 ES ES99900983T patent/ES2175930T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69901161D1 (de) | 2002-05-08 |
FR2774092A1 (fr) | 1999-07-30 |
FR2774092B1 (fr) | 2000-02-18 |
EP1051257B1 (fr) | 2002-04-03 |
WO1999037399A1 (fr) | 1999-07-29 |
EP1051257A1 (fr) | 2000-11-15 |
DE69901161T2 (de) | 2002-11-28 |
US6372903B1 (en) | 2002-04-16 |
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Legal Events
Date | Code | Title | Description |
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FG2A | Definitive protection |
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