ES2173988T3 - Derivados de furano para inhibir la neumonia por pneumocistis carinii, giardia lamblia y criptosporidium parvum. - Google Patents
Derivados de furano para inhibir la neumonia por pneumocistis carinii, giardia lamblia y criptosporidium parvum.Info
- Publication number
- ES2173988T3 ES2173988T3 ES95941407T ES95941407T ES2173988T3 ES 2173988 T3 ES2173988 T3 ES 2173988T3 ES 95941407 T ES95941407 T ES 95941407T ES 95941407 T ES95941407 T ES 95941407T ES 2173988 T3 ES2173988 T3 ES 2173988T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- rent
- low
- group
- giardia lamblia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
Abstract
LA PRESENTE INVENCION PROPORCIONA METODOS PARA EL TRATAMIENTO DE NEUMONIA PNEUMOCYSTIS CARINII, GIARDIA LAMBLIA Y CRYPTOSPORIDIUM PARVUM EN UN SUJETO QUE NECESITE TAL TRATAMIENTO. LOS METODOS COMPRENDE LA ADMINISTRACION AL SUJETO DE UN COMPUESTO DE FORMULA (I), EN DONDE R{SUB,1} Y R{SUB,2} SON CADA UNO INDEPENDIENTEMENTE SELECCIONADOS DEL GRUPO QUE CONSISTEN EN H, ALQUILO BAJO, ARILO, ALQUILARILO, AMINOALQUILO, AMINOARILO, HALOGENO, OXIALQUILO, OXIARILO U OXIARILALQUILO; R{SUB,3} Y R{SUB,4} SON CADA UNO INDEPENDIENTEMENTE SELECCIONADOS DEL GRUPO QUE CONSISTE EN H, ALQUILO BAJO, OXIALQUILO, ALQUILARILO, ARILO, OXIARILO, AMINOALQUILO, AMINOARILO O HALOGENO; Y X E Y ESTAN LOCALIZADOS EN LAS POSICIONES PARA O META Y SE SELECCIONAN DEL GRUPO QUE CONSISTE EN H, ALQUILO BAJO, OXIALQUILO, Y (A) EN DONDE CADA R{SUB,5} ES INDEPENDIENTEMENTE SELECCIONADO DEL GRUPO QUE CONSISTEN EN H, ALQUILO BAJO, ALCOXIALQUILO, HIDROXIALQUILO, AMINOALQUILO, ALQUILAMINOALQUILO, CICLOALQUILO, ARILO O ALQUILARILO O DOSGRUPOS R{SUB,5} JUNTOS REPRESENTAN ALQUILO C{SUB,2}-C{SUB,10}, HIDROXIALQUILO, O ALQUILENO; Y R{SUB,6} ES H, HIDROXIDO, ALQUILO BAJO, ALCOXIALQUILO, HIDROXIALQUILO, AMINOALQUILO, ALQUILAMINO, ALQUILAMINOALQUILO, CICLOALQUILO, HIDROXICICLOALQUILO, ALCOXICICLOALQUILO, ARILO O ALQUIARILO; O O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. LOS COMPUESTOS SE ADMINISTRAN EN UNA CANTIDAD EFICAZ PARA TRATAR LA CONDICION. LA PRESENTE INVENCION TAMBIEN INCLUYE NUEVOS COMPUESTOS UTILES EN EL TRATAMIENTO DE NEUMONIA PNEUMOCYSTIS CARINII, GIARDIA LAMBLIA Y CRYPTOSPORIDIUM PARVUM.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33948794A | 1994-11-14 | 1994-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2173988T3 true ES2173988T3 (es) | 2002-11-01 |
Family
ID=23329224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95941407T Expired - Lifetime ES2173988T3 (es) | 1994-11-14 | 1995-11-13 | Derivados de furano para inhibir la neumonia por pneumocistis carinii, giardia lamblia y criptosporidium parvum. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0792271B1 (es) |
JP (1) | JP4023753B2 (es) |
AR (1) | AR003104A1 (es) |
AT (1) | ATE213737T1 (es) |
AU (1) | AU692024B2 (es) |
CA (1) | CA2204898A1 (es) |
DE (1) | DE69525644T2 (es) |
ES (1) | ES2173988T3 (es) |
IL (1) | IL115875A (es) |
WO (1) | WO1996015126A1 (es) |
ZA (1) | ZA959661B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5723495A (en) * | 1995-11-16 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Benzamidoxime prodrugs as antipneumocystic agents |
US6008247A (en) * | 1998-02-27 | 1999-12-28 | The University Of North Carolina At Chapel Hill | 2,4-bis[(4-amidino)phenyl]furans as anti-Pneumocystis carinii agents |
ATE239003T1 (de) | 1998-08-20 | 2003-05-15 | Univ North Carolina | Dibenzothiophene derivate und ihre verwendung |
EP1013649A1 (en) * | 1998-12-22 | 2000-06-28 | Chisso Corporation | Liquid crystal compounds incorporating furan ring, liquid crystal composition and liquid crystal display device |
GB2351081A (en) * | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
US7163955B2 (en) | 2001-01-13 | 2007-01-16 | The University Of North Carolina At Chapel Hill | Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection |
US7256203B2 (en) * | 2002-11-27 | 2007-08-14 | The University Of North Carolina At Chapel Hill | Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents |
US7262223B2 (en) | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
EP2034981A1 (en) * | 2006-03-27 | 2009-03-18 | The Government of the United States of America as Represented by The Department of Health and Human Services | Diamidine inhibitors of tdp1 |
-
1995
- 1995-11-05 IL IL11587595A patent/IL115875A/xx not_active IP Right Cessation
- 1995-11-13 JP JP51632796A patent/JP4023753B2/ja not_active Expired - Fee Related
- 1995-11-13 ES ES95941407T patent/ES2173988T3/es not_active Expired - Lifetime
- 1995-11-13 DE DE69525644T patent/DE69525644T2/de not_active Expired - Fee Related
- 1995-11-13 AU AU42838/96A patent/AU692024B2/en not_active Ceased
- 1995-11-13 CA CA002204898A patent/CA2204898A1/en not_active Abandoned
- 1995-11-13 AT AT95941407T patent/ATE213737T1/de not_active IP Right Cessation
- 1995-11-13 WO PCT/US1995/014893 patent/WO1996015126A1/en active IP Right Grant
- 1995-11-13 EP EP95941407A patent/EP0792271B1/en not_active Expired - Lifetime
- 1995-11-14 ZA ZA959661A patent/ZA959661B/xx unknown
- 1995-11-14 AR ARP950100169A patent/AR003104A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
DE69525644T2 (de) | 2002-10-17 |
CA2204898A1 (en) | 1996-05-23 |
EP0792271A1 (en) | 1997-09-03 |
JP4023753B2 (ja) | 2007-12-19 |
ATE213737T1 (de) | 2002-03-15 |
IL115875A (en) | 2000-12-06 |
JPH10508857A (ja) | 1998-09-02 |
DE69525644D1 (de) | 2002-04-04 |
MX9703611A (es) | 1998-07-31 |
ZA959661B (en) | 1996-05-29 |
EP0792271B1 (en) | 2002-02-27 |
AU4283896A (en) | 1996-06-06 |
AR003104A1 (es) | 1998-07-08 |
WO1996015126A1 (en) | 1996-05-23 |
AU692024B2 (en) | 1998-05-28 |
IL115875A0 (en) | 1996-01-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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