ES2173615T3 - Separacion de enatiomeros de octahidroisoquinolina. - Google Patents

Separacion de enatiomeros de octahidroisoquinolina.

Info

Publication number
ES2173615T3
ES2173615T3 ES98944648T ES98944648T ES2173615T3 ES 2173615 T3 ES2173615 T3 ES 2173615T3 ES 98944648 T ES98944648 T ES 98944648T ES 98944648 T ES98944648 T ES 98944648T ES 2173615 T3 ES2173615 T3 ES 2173615T3
Authority
ES
Spain
Prior art keywords
octahydroisoquinoline
enatiomers
separation
racemic
methoxybenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98944648T
Other languages
English (en)
Inventor
Iulia Demian
Kenneth D Stanley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B I Chemicals Inc
Original Assignee
B I Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B I Chemicals Inc filed Critical B I Chemicals Inc
Application granted granted Critical
Publication of ES2173615T3 publication Critical patent/ES2173615T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para la separación del enantiómero (-) de **fórmula** a partir de una mezcla racémica, que implica resolver la mezcla racémica usando ácido (-)mandélico para provocar la formación de sal diastereométrica con una retirada subsiguiente del (-)enantiómero (-) mandelato y teniendo las aguas madres resultantes principalmente el enantiómero (+), caracterizado por que las aguas madres se tratan con ácido fórmico para formar una sal casi racémica de baja solubilidad, se retira la sal casi racémica de las aguas madres por filltración y se somete la sal casi racémica a resolución con ácido (-)mandélico.
ES98944648T 1997-09-17 1998-09-02 Separacion de enatiomeros de octahidroisoquinolina. Expired - Lifetime ES2173615T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5919397P 1997-09-17 1997-09-17

Publications (1)

Publication Number Publication Date
ES2173615T3 true ES2173615T3 (es) 2002-10-16

Family

ID=22021401

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98944648T Expired - Lifetime ES2173615T3 (es) 1997-09-17 1998-09-02 Separacion de enatiomeros de octahidroisoquinolina.

Country Status (10)

Country Link
US (1) US6063925A (es)
EP (1) EP1015432B1 (es)
JP (1) JP2001516746A (es)
AT (1) ATE216989T1 (es)
CA (1) CA2303972A1 (es)
DE (1) DE69805193T2 (es)
DK (1) DK1015432T3 (es)
ES (1) ES2173615T3 (es)
PT (1) PT1015432E (es)
WO (1) WO1999014198A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016752A1 (en) * 1997-09-30 1999-04-08 Molecular Designs International, Inc. β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USING
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3436179A1 (de) * 1984-10-03 1986-04-10 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur herstellung optisch aktiver amine
US5892044A (en) * 1995-07-11 1999-04-06 Lonza Ltd. Process for preparing optically active 1-(p-methoxybenzyl)-1,2,3,4,5,3,7,8-octahydroisoquinoline

Also Published As

Publication number Publication date
US6063925A (en) 2000-05-16
DE69805193T2 (de) 2003-05-15
PT1015432E (pt) 2002-09-30
EP1015432A1 (en) 2000-07-05
DK1015432T3 (da) 2002-07-08
WO1999014198A1 (en) 1999-03-25
EP1015432B1 (en) 2002-05-02
ATE216989T1 (de) 2002-05-15
DE69805193D1 (de) 2002-06-06
CA2303972A1 (en) 1999-03-25
JP2001516746A (ja) 2001-10-02

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