ES2164564B1 - TRISUSTITUTED BENCHES UNITED TO AMIDAS, ESTERS AND CARBOXYL ACIDS AS NEW INHIBITORS OF CYCLLOXYGENASA II. - Google Patents
TRISUSTITUTED BENCHES UNITED TO AMIDAS, ESTERS AND CARBOXYL ACIDS AS NEW INHIBITORS OF CYCLLOXYGENASA II.Info
- Publication number
- ES2164564B1 ES2164564B1 ES9902287A ES9902287A ES2164564B1 ES 2164564 B1 ES2164564 B1 ES 2164564B1 ES 9902287 A ES9902287 A ES 9902287A ES 9902287 A ES9902287 A ES 9902287A ES 2164564 B1 ES2164564 B1 ES 2164564B1
- Authority
- ES
- Spain
- Prior art keywords
- sup
- sub
- esters
- cyclooxygenase
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Bencenos trisustituidos unidos a amidas, ésteres y ácidos carboxílicos como nuevos inhibidores de la ciclooxigenasa II. La presente invención se refiere a compuesto de fórmula general I, **FORMULA** inhibidores selectivos de la ciclooxigenasa-II, en los que el grupo D es un grupo - C(R{sup,2}) (R{sup,3}) -C(R{sup,4}) (R{sup,5})-, - C(R{sup,2})=C(R{sup,4}- ó -C C-; A es un birradical -CO-, -O-, -S-, ó -NH-; X es un átomo de oxígeno o un grupo -N(R{sup,6})- y E es halógeno, (C{sub,1}-C{sub,6})-alquilo, (C{sub,2}- C{sub,6})-alquenilo, C{sub,2}-C{sub,6 })-alquinilo, etc., a sus sales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contiene. Los compuestos de la presente invención son útiles en el tratamiento de la inflamación, dolor y fiebre, así como de aquellas otras afecciones que recientemente se han asociado con las cilooxigenasas, especialmente con la ciclooxigenasa-II, como ejemplo el cáncer colorectal y Alzheimer.Trisubstituted benzenes bound to amides, esters and carboxylic acids as new inhibitors of cyclooxygenase II. The present invention relates to a compound of general formula I, ** FORMULA ** selective inhibitors of cyclooxygenase-II, in which group D is a group-C (R {sup, 2}) (R {sup, 3 }) -C (R {sup, 4}) (R {sup, 5}) -, - C (R {sup, 2}) = C (R {sup, 4} - or -C C-; A is a biradical -CO-, -O-, -S-, or -NH-; X is an oxygen atom or a group -N (R {sup, 6}) - and E is halogen, (C {sub, 1 } -C {sub, 6}) - alkyl, (C {sub, 2} - C {sub, 6}) - alkenyl, C {sub, 2} -C {sub, 6}) - alkynyl, etc., to its pharmaceutically acceptable salts and solvates, and to the pharmaceutical compositions containing them. The compounds of the present invention are useful in the treatment of inflammation, pain and fever, as well as those other conditions that have recently been associated with cyclooxygenases, especially with cyclooxygenase-II, as an example colorectal cancer and Alzheimer's.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9902287A ES2164564B1 (en) | 1999-10-18 | 1999-10-18 | TRISUSTITUTED BENCHES UNITED TO AMIDAS, ESTERS AND CARBOXYL ACIDS AS NEW INHIBITORS OF CYCLLOXYGENASA II. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9902287A ES2164564B1 (en) | 1999-10-18 | 1999-10-18 | TRISUSTITUTED BENCHES UNITED TO AMIDAS, ESTERS AND CARBOXYL ACIDS AS NEW INHIBITORS OF CYCLLOXYGENASA II. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2164564A1 ES2164564A1 (en) | 2002-02-16 |
| ES2164564B1 true ES2164564B1 (en) | 2003-02-16 |
Family
ID=8310284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9902287A Expired - Fee Related ES2164564B1 (en) | 1999-10-18 | 1999-10-18 | TRISUSTITUTED BENCHES UNITED TO AMIDAS, ESTERS AND CARBOXYL ACIDS AS NEW INHIBITORS OF CYCLLOXYGENASA II. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2164564B1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120752A (en) * | 1989-12-28 | 1992-06-09 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
| DE4126662A1 (en) * | 1991-08-13 | 1993-02-18 | Boehringer Mannheim Gmbh | NEW 3,5-DI-TERT.BUTYL-4-HYDROXYPHENYL DERIVATIVES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
| US5604253A (en) * | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| JPH10182583A (en) * | 1996-12-25 | 1998-07-07 | Mitsui Chem Inc | New hydroxamic acid derivative |
-
1999
- 1999-10-18 ES ES9902287A patent/ES2164564B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2164564A1 (en) | 2002-02-16 |
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Legal Events
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