ES2163418T3 - Inhibidores de una proteasa que es capaz de separar el receptor tnf soluble p55 del receptor tnf unido a la celula. - Google Patents

Inhibidores de una proteasa que es capaz de separar el receptor tnf soluble p55 del receptor tnf unido a la celula.

Info

Publication number
ES2163418T3
ES2163418T3 ES94116018T ES94116018T ES2163418T3 ES 2163418 T3 ES2163418 T3 ES 2163418T3 ES 94116018 T ES94116018 T ES 94116018T ES 94116018 T ES94116018 T ES 94116018T ES 2163418 T3 ES2163418 T3 ES 2163418T3
Authority
ES
Spain
Prior art keywords
tnf
receiver
inhibitors
cell
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94116018T
Other languages
English (en)
Inventor
David Wallach
Cord Brackebusch
Eugene Varfolomeev
Michael Batkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of ES2163418T3 publication Critical patent/ES2163418T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

SE PRESENTAN MOLECULAS QUE INFLUYEN EN LA EFUSION DEL RECEPTOR DEL FACTOR DE NECROSIS DE TUMOR DE ENLACE CELULAR P55 (P55-TNFR), JUNTO CON METODOS DE PRODUCIRLO. MAS EN PARTICULAR, EL INVENTO SE REFIERE A LAS PROTEASAS QUE DIVIDEN EL TNF-R DE ENLACE CELULAR P55, CREANDO DE ESTA MANERA EL RECEPTOR SOLUBLE, Y A LOS INHIBIDORES DE ESTAS PROTEASAS QUE COMPRENDEN LA SECUENCIA ASN172 A THR-182 DE P55-TNF-R O SUS VARIANTES.
ES94116018T 1993-10-12 1994-10-11 Inhibidores de una proteasa que es capaz de separar el receptor tnf soluble p55 del receptor tnf unido a la celula. Expired - Lifetime ES2163418T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL107268A IL107268A0 (en) 1993-10-12 1993-10-12 Molecules influencing the shedding of the tnf receptor, their preparation and their use

Publications (1)

Publication Number Publication Date
ES2163418T3 true ES2163418T3 (es) 2002-02-01

Family

ID=11065340

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94116018T Expired - Lifetime ES2163418T3 (es) 1993-10-12 1994-10-11 Inhibidores de una proteasa que es capaz de separar el receptor tnf soluble p55 del receptor tnf unido a la celula.

Country Status (13)

Country Link
US (2) US5665859A (es)
EP (1) EP0657536B1 (es)
JP (1) JPH07194376A (es)
AT (1) ATE203273T1 (es)
AU (1) AU679559B2 (es)
CA (1) CA2133872A1 (es)
DE (1) DE69427740T2 (es)
DK (1) DK0657536T3 (es)
ES (1) ES2163418T3 (es)
GR (1) GR3036782T3 (es)
IL (1) IL107268A0 (es)
PT (1) PT657536E (es)
ZA (1) ZA947962B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264944B1 (en) * 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
JPH03164179A (ja) * 1989-04-21 1991-07-16 Boehringer Ingelheim Internatl Gmbh Ｔｎｆレセプター、ｔｎｆ結合たん白質およびこれらをコードするｄｎａ
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5837458A (en) * 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
ATE403714T1 (de) * 1996-11-06 2008-08-15 Univ California Tumor necrosis factor rezeptor abspaltendes enzym,dessen zubereitungen und verwendungen
US6930084B1 (en) 1996-11-06 2005-08-16 The Regents Of The University Of California Treating arthritis with TNF receptor releasing enzyme
US20050191661A1 (en) * 1996-11-06 2005-09-01 Tetsuya Gatanaga Treatment of inflammatory disease by cleaving TNF receptors
US6593456B1 (en) 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US6989435B2 (en) * 1997-09-11 2006-01-24 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6406907B1 (en) * 1999-02-26 2002-06-18 Iowa State University Research Foundation Bovine tumor necrosis factor receptor-1 and methods of use
WO2001064856A2 (en) * 2000-02-28 2001-09-07 The Government Of The United States Of America, A S Represented By The Secretary, Department Of Hea Lth And Human Services Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding
CA2466298A1 (en) * 2001-11-30 2003-06-05 Applied Research Systems Ars Holding N.V. Methods of increasing protein expression levels
JP2009515523A (ja) * 2005-11-10 2009-04-16 サンタリス ファーマ アー／エス Ｔｎｆスーパーファミリー受容体に対するスプライス切替オリゴマーならびに疾病治療における該オリゴマーの使用
US7785834B2 (en) * 2005-11-10 2010-08-31 Ercole Biotech, Inc. Soluble TNF receptors and their use in treatment of disease
WO2007134384A2 (en) * 2006-05-19 2007-11-29 Children Youth And Women's Health Service Selective modulation of receptor signalling
US20090264353A1 (en) * 2007-10-19 2009-10-22 Santaris Pharma A/S Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease
CN102574907B (zh) * 2009-10-19 2015-10-21 韩诺生物制药株式会社 修饰的人肿瘤坏死因子受体i多肽或其片段以及制备它们的方法
US10723532B2 (en) 2017-05-22 2020-07-28 Bedford Insutries, Inc. Elastic band package
US11021339B2 (en) 2017-05-22 2021-06-01 Bedford Industries, Inc. Elastic band dispenser

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101769A (en) * 1992-05-03 2007-02-11 Yeda Res & Dev Modulation of TNF receptor action

Also Published As

Publication number Publication date
DE69427740D1 (de) 2001-08-23
ZA947962B (en) 1995-11-21
IL107268A0 (en) 1994-01-25
AU7574294A (en) 1995-05-04
DK0657536T3 (da) 2001-09-17
ATE203273T1 (de) 2001-08-15
GR3036782T3 (en) 2002-01-31
US5665859A (en) 1997-09-09
US5766917A (en) 1998-06-16
EP0657536B1 (en) 2001-07-18
CA2133872A1 (en) 1995-04-13
AU679559B2 (en) 1997-07-03
PT657536E (pt) 2001-12-28
EP0657536A1 (en) 1995-06-14
DE69427740T2 (de) 2002-05-23
JPH07194376A (ja) 1995-08-01

Similar Documents

Publication Publication Date Title
ES2163418T3 (es) Inhibidores de una proteasa que es capaz de separar el receptor tnf soluble p55 del receptor tnf unido a la celula.
ES2145451T3 (es) Secuencia de dna y proteina de cancer de mamas codificada especifica para mamas.
DE59200089D1 (de) Hochdruckentladungslampe kleiner Leistung.
DE69027990D1 (de) Kultur des wachstumsfaktors der vaskularen endothelialzellen und dns, die dafür kodiert
DK1305286T3 (da) Cyclopentanoindoler, præparater indeholdende sådanne forbindelser og fremgangsmåder til behandling
DK0907652T3 (da) Immunosuppressive forbindelser og fremgangsmåder
ES2081857T3 (es) Nuevos inhibidores de alpha-glucosidasa.
ATE312188T1 (de) Lokalisierung von therapeutischen mitteln
CU22997A3 (es) Proteína híbrida para la inhibición de la desgranulación de los mastocitos y su utilización
DK0515544T3 (da) Steroidsulfataseinhibitorer
ES2186803T3 (es) Peptidos tio-sustituidos como inhibidores de metaloproteinasas y de la liberacion de tnf.
DE3865553D1 (de) Elektrodenlose niederdruckentladungslampe.
DK1097173T3 (da) Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
ES2173433T3 (es) Procedimiento para la cristalizacion de losartan.
ES2123745T3 (es) Procedimiento para evaluar la calidad de las señales vocales de las señales sintetizadas.
ES2058191T3 (es) Acidos 2-fenil-4-quinolincarboxilicos substituidos.
DE3854187D1 (de) Hochdruckentladungslampe.
DE69535961D1 (de) T-zellaktivierung
ES2132419T3 (es) Nuevos agentes de nucleosidos 9-n-biciclicos utiles como inhibidores selectivos de citocinas proinflamatorias.
ES2166900T3 (es) Derivados de ara-c.
DE3887464T2 (de) Kaltkathodenentladungslampe.
AR009819A1 (es) Inhibidores de la proteasa proteinicos estabilizados y sus variantes
NO955288L (no) Skvalen-syntetase inhibitorer
NO995959D0 (no) Modulatorer av intracellulaer inflammasjon, celledöd og celleoverlevelsesreaksjonsveier
DK1143917T3 (da) Antikonvulsive derivater egnet til behandling af posttraumatisk stresssygdom

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 657536

Country of ref document: ES