ES2160197T3 - Empleo de una sal de sodio o de lisinio de derivados de amida del acido crotonico para la preparacion de un medicamento para el tratamiento de enfermedades cancerigenas. - Google Patents
Empleo de una sal de sodio o de lisinio de derivados de amida del acido crotonico para la preparacion de un medicamento para el tratamiento de enfermedades cancerigenas.Info
- Publication number
- ES2160197T3 ES2160197T3 ES96116408T ES96116408T ES2160197T3 ES 2160197 T3 ES2160197 T3 ES 2160197T3 ES 96116408 T ES96116408 T ES 96116408T ES 96116408 T ES96116408 T ES 96116408T ES 2160197 T3 ES2160197 T3 ES 2160197T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- crotonic acid
- lisinium
- cancerigene
- employment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 229910052708 sodium Inorganic materials 0.000 title 1
- 239000011734 sodium Substances 0.000 title 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19539638A DE19539638A1 (de) | 1995-10-25 | 1995-10-25 | Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2160197T3 true ES2160197T3 (es) | 2001-11-01 |
Family
ID=7775689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96116408T Expired - Lifetime ES2160197T3 (es) | 1995-10-25 | 1996-10-14 | Empleo de una sal de sodio o de lisinio de derivados de amida del acido crotonico para la preparacion de un medicamento para el tratamiento de enfermedades cancerigenas. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5886033A (enExample) |
| EP (1) | EP0769296B1 (enExample) |
| JP (1) | JP3996658B2 (enExample) |
| AT (1) | ATE202704T1 (enExample) |
| CA (1) | CA2188228C (enExample) |
| DE (2) | DE19539638A1 (enExample) |
| DK (1) | DK0769296T3 (enExample) |
| ES (1) | ES2160197T3 (enExample) |
| GR (1) | GR3036754T3 (enExample) |
| PT (1) | PT769296E (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1012150A4 (en) * | 1997-05-19 | 2002-05-29 | Sugen Inc | HETEROARYLCARBOXAMIDE COMPOUNDS THAT ARE EFFECTIVE OF DISEASES CAUSED BY PROTEIN-TYROSIN-KINASE |
| US6316479B1 (en) | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
| DK0987256T3 (da) * | 1997-08-08 | 2002-02-11 | Aventis Pharma Gmbh | Krystalform af N-(4-trifluormethylphenyl)-5-methylisoxazol-4-carboxylsyreamid |
| EP0933633A1 (en) | 1997-12-11 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Process for obtaining L-dihydroorotic acid and use thereof |
| DE19857009A1 (de) * | 1998-12-10 | 2000-06-15 | Aventis Pharma Gmbh | Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren |
| WO2004056746A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| US7247736B2 (en) * | 2002-12-23 | 2007-07-24 | 4Sc Ag | Method of identifying inhibitors of DHODH |
| US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| CN101006065B (zh) | 2004-06-17 | 2012-07-11 | 英菲尼蒂发现公司 | 抑制bcl蛋白与结合伴侣的相互作用的化合物和方法 |
| US7842815B2 (en) | 2004-06-17 | 2010-11-30 | Infinity Pharmaceuticals, Inc. | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners |
| DE102006014165A1 (de) * | 2006-03-24 | 2007-09-27 | Schebo Biotech Ag | Neue Isooxazol-Derivate und deren Verwendungen |
| TWI389895B (zh) | 2006-08-21 | 2013-03-21 | Infinity Discovery Inc | 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法 |
| CN108472280A (zh) * | 2015-09-01 | 2018-08-31 | 布罗德研究所股份有限公司 | 用于治疗或者预防血液癌症的化合物和方法 |
| CN111423374B (zh) * | 2020-05-18 | 2023-03-21 | 合肥工业大学 | 一种二氢吡唑磺酰胺类化合物及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL186239B (nl) * | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
| DE2854439A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
| DE59010701D1 (de) * | 1990-05-18 | 1997-05-22 | Hoechst Ag | Isoxazol-4-carbonsäureamide und hydroxyalkyliden-cyanessigsäureamide, diese verbindungen enthaltende arzneimittel und deren verwendung |
| IL99811A (en) * | 1990-10-30 | 1996-03-31 | Roussel Uclaf | 3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them |
| ES2079765T3 (es) * | 1991-10-23 | 1996-01-16 | Hoechst Ag | Derivados de amidas de acido n-fenil-2-ciano-3-hidroxicrotonico y su utilizacion como medicamento con propiedad inmunomoduladora. |
| GB9200275D0 (en) * | 1992-01-08 | 1992-02-26 | Roussel Lab Ltd | Chemical compounds |
| GB9320299D0 (en) * | 1993-10-01 | 1993-11-17 | Roussel Lab Ltd | Isoxazole derivatives |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
-
1995
- 1995-10-25 DE DE19539638A patent/DE19539638A1/de not_active Withdrawn
-
1996
- 1996-10-14 DK DK96116408T patent/DK0769296T3/da active
- 1996-10-14 ES ES96116408T patent/ES2160197T3/es not_active Expired - Lifetime
- 1996-10-14 EP EP96116408A patent/EP0769296B1/de not_active Expired - Lifetime
- 1996-10-14 PT PT96116408T patent/PT769296E/pt unknown
- 1996-10-14 DE DE59607208T patent/DE59607208D1/de not_active Expired - Lifetime
- 1996-10-14 AT AT96116408T patent/ATE202704T1/de active
- 1996-10-16 US US08/733,050 patent/US5886033A/en not_active Expired - Lifetime
- 1996-10-18 CA CA002188228A patent/CA2188228C/en not_active Expired - Fee Related
- 1996-10-24 JP JP28191896A patent/JP3996658B2/ja not_active Expired - Fee Related
-
1998
- 1998-11-13 US US09/191,375 patent/US6020372A/en not_active Expired - Lifetime
-
2001
- 2001-09-28 GR GR20010401611T patent/GR3036754T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2188228C (en) | 2008-08-12 |
| ATE202704T1 (de) | 2001-07-15 |
| DK0769296T3 (da) | 2001-10-22 |
| EP0769296A1 (de) | 1997-04-23 |
| DE59607208D1 (de) | 2001-08-09 |
| PT769296E (pt) | 2001-11-30 |
| CA2188228A1 (en) | 1997-04-26 |
| JPH09165336A (ja) | 1997-06-24 |
| JP3996658B2 (ja) | 2007-10-24 |
| US6020372A (en) | 2000-02-01 |
| EP0769296B1 (de) | 2001-07-04 |
| GR3036754T3 (en) | 2001-12-31 |
| DE19539638A1 (de) | 1997-04-30 |
| US5886033A (en) | 1999-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2160197T3 (es) | Empleo de una sal de sodio o de lisinio de derivados de amida del acido crotonico para la preparacion de un medicamento para el tratamiento de enfermedades cancerigenas. | |
| LU91587I2 (fr) | Agomélatine et ses dérivés pharmaceutiquement acceptables (VALDOXAN) | |
| DE68919010D1 (de) | Purinverbindungen, Verfahren zu ihrer Herstellung und pharmazeutische Präparate. | |
| MX9201584A (es) | Compuestos antibioticos. | |
| ES2042807T3 (es) | 6-fenil-dihidro-3(2h)-piridazinonas, procedimiento para su preparacion, y medicamentos que contienen estos compuestos. | |
| BR9507231A (pt) | Uso de derivados de ácido carboxílico para a produção de drogas | |
| ES2147749T3 (es) | Procedimiento para la preparacion de derivados de ciano-metoxiiminometilo. | |
| SE8700714L (sv) | Anvendning av substituerade 4-fenyl-4-oxo-2-butensyraderivat for framstellning av lekemedel for behandling av sjukdomar i matsmeltningskanalen och som antiulcerost lekemedel | |
| ATE91682T1 (de) | Alkansulfonanilid-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung. | |
| PT821952E (pt) | Utilizacao de derivados de isoxazole e da amida do acido crotonico para a modulacao da apoptose | |
| ZA964842B (en) | Indole indazole and benzisoxazole compounds their process of preparation and the pharmaceutical compositions which contain them | |
| DE69132578D1 (de) | Cephemderivate | |
| ES523426A0 (es) | Un metodo para preparar nuevos derivados de guanina | |
| ATE112267T1 (de) | Diacylglycerol-nicotinate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. | |
| ES2143276T3 (es) | Derivados de amidas del acido 2-ciano-3,5-dihidroxi-hex-2-eno-carboxilico, procedimiento para su preparacion y su empleo como medicamentos. | |
| DK0598765T3 (da) | 2-Aminonaphthyridin-derivat, dets fremstilling og anvendelse | |
| DE69611594D1 (de) | Tetrazyclisch 1,4-Oxazinverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen | |
| ES8101583A1 (es) | Un procedimiento para la preparacion de una quinazolina | |
| PT98186A (pt) | Processo para a preparacao de purinil- e de pirimidinil-tetra-hidrofuranos e de composicoes farmaceuticas que os contem | |
| MX9205408A (es) | Metodo para tratar hipertension. | |
| KR950704322A (ko) | 스피로푸라논 유도체 및 그의 신경변성 질환 치료 용도(Spirofuranone Derivatives and Their Use in the Treatment of Neurodegenerative Disorders) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 769296 Country of ref document: ES |