ES2158776A1 - Procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes. - Google Patents

Procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes.

Info

Publication number
ES2158776A1
ES2158776A1 ES009900757A ES9900757A ES2158776A1 ES 2158776 A1 ES2158776 A1 ES 2158776A1 ES 009900757 A ES009900757 A ES 009900757A ES 9900757 A ES9900757 A ES 9900757A ES 2158776 A1 ES2158776 A1 ES 2158776A1
Authority
ES
Spain
Prior art keywords
mixture
gamma globulin
preparation
animal origin
plasma proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009900757A
Other languages
English (en)
Other versions
ES2158776B1 (es
Inventor
Pozo Francisco J Polo
Canel Carmen Rodriguez
Navarro Jesus Rodenas
Martin M Nieves Saborido
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
APC Europe SA
Original Assignee
APC Europe SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by APC Europe SA filed Critical APC Europe SA
Priority to ES9900757A priority Critical patent/ES2158776B1/es
Priority to ES200000933A priority patent/ES2170654B1/es
Priority to EP00500066A priority patent/EP1044690B1/en
Priority to AT00500066T priority patent/ATE300956T1/de
Priority to DE60021644T priority patent/DE60021644D1/de
Priority to ES00500066T priority patent/ES2243223T3/es
Publication of ES2158776A1 publication Critical patent/ES2158776A1/es
Application granted granted Critical
Publication of ES2158776B1 publication Critical patent/ES2158776B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procedimiento para la obtención de gammaglobulinas de origen animal y aplicaciones correspondientes; el procedimiento comprende diluir un primer concentrado de gammaglobulina en agua en proporción 1:7-1:11; ajuste del pH a un valor 3-6; añadir polietilenglicol en proporción 2-6% en peso; centrifugación a una velocidad de 3000-11000 g obteniendo una primera fracción clarificada rica en gammaglobulina, que se separa; ajuste de su pH a 6-9; nueva adición de polietilenglicol en proporción en peso 6-12%; segunda centrifugación a una velocidad de 3000-11000 g resultando una segunda fracción insolubilizada compuesta mayoritariamente por gammaglobulina y una segunda fracción clarificada, que se separan. Las aplicaciones de proteínas con más del 90% de gammaglobulina son para la preparación de composiciones medicamentosas aptas: para prevención y tratamiento de enfermedades gastrointestinales; para mejora del estado inmunológico; y para el tratamiento de procesos de malabsorción en humanos y animales.
ES9900757A 1999-04-13 1999-04-13 Procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes. Expired - Fee Related ES2158776B1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES9900757A ES2158776B1 (es) 1999-04-13 1999-04-13 Procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes.
ES200000933A ES2170654B1 (es) 1999-04-13 2000-04-11 Perfeccionamientos introducidos en el objeto de la patente p9900757, por un procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes.
EP00500066A EP1044690B1 (en) 1999-04-13 2000-04-12 Applications of gamma globulin-rich plasma protein mixtures of animal origin and process for the preparation thereof
AT00500066T ATE300956T1 (de) 1999-04-13 2000-04-12 Anwendung und herstellungsverfahren von tierischen gammaglobulin-reichen plasmaprotein mischungen
DE60021644T DE60021644D1 (de) 1999-04-13 2000-04-12 Anwendung und Herstellungsverfahren von tierischen Gammaglobulin-reichen Plasmaprotein Mischungen
ES00500066T ES2243223T3 (es) 1999-04-13 2000-04-12 Aplicaciones de mezclas de proteinas plasmaticas de origen animal en gammaglobulinas y procedimiento para su preparacion.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9900757A ES2158776B1 (es) 1999-04-13 1999-04-13 Procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes.

Publications (2)

Publication Number Publication Date
ES2158776A1 true ES2158776A1 (es) 2001-09-01
ES2158776B1 ES2158776B1 (es) 2002-03-16

Family

ID=8308004

Family Applications (2)

Application Number Title Priority Date Filing Date
ES9900757A Expired - Fee Related ES2158776B1 (es) 1999-04-13 1999-04-13 Procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes.
ES200000933A Expired - Fee Related ES2170654B1 (es) 1999-04-13 2000-04-11 Perfeccionamientos introducidos en el objeto de la patente p9900757, por un procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES200000933A Expired - Fee Related ES2170654B1 (es) 1999-04-13 2000-04-11 Perfeccionamientos introducidos en el objeto de la patente p9900757, por un procedimiento para la obtencion de gammaglobulinas de origen animal y aplicaciones correspondientes.

Country Status (1)

Country Link
ES (2) ES2158776B1 (es)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0064210A1 (en) * 1981-05-01 1982-11-10 Miles Inc. Oral pharmaceutical composition containing immune globulin
JPS6428A (en) * 1987-06-22 1989-01-05 Chemo Sero Therapeut Res Inst Prophylactic and remedy for horse infections
JPH01230533A (ja) * 1987-11-20 1989-09-14 Green Cross Corp:The 抗エイズウイルス抗体陽性静注用免疫グロブリン製剤の製造方法
EP0338229A1 (de) * 1988-04-19 1989-10-25 Biotest Pharma Gmbh Präparat mit Antikörperaktivität und breitem Wirkungsspektrum, daraus bestehende oder diese enthaltende Mittel und deren Verwendung zur Behandlung von bakteriell oder toxin-bedingten Erkrankungen und zur Bekämpfung von Protozoen
US5531989A (en) * 1994-10-28 1996-07-02 Metagenics, Inc. Immunoglobulin and fiber-containing composition for human gastrointestinal health

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK166763B1 (da) * 1983-03-16 1993-07-12 Immuno Ag Immunoglobulin-g-holdig fraktion
AU753468B2 (en) * 1998-06-09 2002-10-17 Csl Behring Ag Process for producing immunoglobulins for intravenous administration and other immunoglobulin products

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0064210A1 (en) * 1981-05-01 1982-11-10 Miles Inc. Oral pharmaceutical composition containing immune globulin
JPS6428A (en) * 1987-06-22 1989-01-05 Chemo Sero Therapeut Res Inst Prophylactic and remedy for horse infections
JPH01230533A (ja) * 1987-11-20 1989-09-14 Green Cross Corp:The 抗エイズウイルス抗体陽性静注用免疫グロブリン製剤の製造方法
EP0338229A1 (de) * 1988-04-19 1989-10-25 Biotest Pharma Gmbh Präparat mit Antikörperaktivität und breitem Wirkungsspektrum, daraus bestehende oder diese enthaltende Mittel und deren Verwendung zur Behandlung von bakteriell oder toxin-bedingten Erkrankungen und zur Bekämpfung von Protozoen
US5531989A (en) * 1994-10-28 1996-07-02 Metagenics, Inc. Immunoglobulin and fiber-containing composition for human gastrointestinal health

Also Published As

Publication number Publication date
ES2170654B1 (es) 2003-06-16
ES2170654A1 (es) 2002-08-01
ES2158776B1 (es) 2002-03-16

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