ES2157216T3 - Metodos de utilizacion de derivados de (2-imidazolin-2-ilamino) quinoxalina. - Google Patents
Metodos de utilizacion de derivados de (2-imidazolin-2-ilamino) quinoxalina.Info
- Publication number
- ES2157216T3 ES2157216T3 ES93903433T ES93903433T ES2157216T3 ES 2157216 T3 ES2157216 T3 ES 2157216T3 ES 93903433 T ES93903433 T ES 93903433T ES 93903433 T ES93903433 T ES 93903433T ES 2157216 T3 ES2157216 T3 ES 2157216T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- independently selected
- mammal
- alkyl radicals
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN METODO DE TRATAMIENTO DE UN MAMIFERO COMPRENDE LA ADMINISTRACION A UN MAMIFERO DE UNA CANTIDAD EFECTIVA PARA PROPORCIONAR LOS EFECTOS TERAPEUTICOS DESEADOS EN EL MAMIFERO DE UN COMPUESTO SELECCIONADO DEL GRUPO CONSISTENTE EN AQUELLOS QUE TIENEN LA FORMULA (1), ACIDO FARMACEUTICAMENTE ACEPTABLE EN ADICION A SALES Y MEZCLAS CONSIGUIENTES, EN LA QUE R1 Y R4 SON SELECCIONADOS INDEPENDIENTEMENTE DEL GRUPO CONSISTENTE EN H Y RADICALES ALQUILOS QUE TIENEN DE 1 A 4 ATOMOS DE CARBONO; LOS R2S SON SELECCIONADOS INDEPENDIENTEMENTE DESDE H O RADICALES ALQUILOS QUE TIENEN DE 1 A 4 ATONOS DE CARBONO O SON, JUNTOS, OXO; EL GRUPO 2 Y R7 ESTAN SITUADOS CADA UNO EN UNA DE LAS POSICIONES 5-, 6-, 7 U 8 MENTE SELECCIONADO DEL GRUPO QUE CONSISTE EN CL, BR, H Y RADICALES ALQUILES QUE TIENEN DE 1 A 3 ATOMOS DE CARBONO. DICHOS COMPUESTOS, CUANDO SE ADMINISTRAN A UN MAMIFERO, PROPORCIONAN LOS DESEADOS EFECTOS TERAPEUTICOS TALES COMO REDUCCION DEL DOLOR PERIFERICO, ANESTESIA DEL SISTEMA NERVIOSO CENTRAL, CONSTRICCION DE UN O MAS VASOS SANGUINEOS, REDUCCION O PREVENCION DE AL MENOS UN DE LOS EFECTOS DE LA ISQUEMIA, DESCONGESTION DE UN O MAS ORIFICIOS NASALES Y REDUCCION DE AL MENOS UN EFECTO DE UN DESORDEN INFLAMATORIO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/820,329 US5231096A (en) | 1989-10-12 | 1992-01-13 | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2157216T3 true ES2157216T3 (es) | 2001-08-16 |
Family
ID=25230500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93903433T Expired - Lifetime ES2157216T3 (es) | 1992-01-13 | 1993-01-12 | Metodos de utilizacion de derivados de (2-imidazolin-2-ilamino) quinoxalina. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5231096A (es) |
EP (1) | EP0620732B1 (es) |
JP (1) | JPH07503015A (es) |
AT (1) | ATE200222T1 (es) |
AU (1) | AU670064B2 (es) |
CA (1) | CA2127542C (es) |
DE (1) | DE69330090T2 (es) |
ES (1) | ES2157216T3 (es) |
WO (1) | WO1993013771A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5326763A (en) * | 1989-10-12 | 1994-07-05 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
US6323204B1 (en) * | 1993-10-13 | 2001-11-27 | Allergan | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
WO1995010280A1 (en) * | 1993-10-13 | 1995-04-20 | Allergan | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
ATE194771T1 (de) * | 1993-12-17 | 2000-08-15 | Procter & Gamble | 6-(2-imidazolinylamino) chinoxalin-verbindungen als alpha-2-adrenorezeptoragonisten |
US5578607A (en) * | 1993-12-17 | 1996-11-26 | The Procter & Gamble Company | 6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists |
US5576437A (en) * | 1993-12-17 | 1996-11-19 | The Procter & Gamble Company | 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists |
US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
BR9408335A (pt) * | 1993-12-17 | 1997-08-19 | Procter & Gamble | Composto uso do mesmo e composição farmacêutica |
DK0693055T3 (da) * | 1994-02-08 | 1997-12-15 | Alcon Lab Inc | Hidtil ukendt fremgangsmåde til fremstilling af clonidinderivater |
US5916900A (en) | 1995-06-29 | 1999-06-29 | The Procter & Gamble Company | 7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists |
NZ504707A (en) | 1997-11-24 | 2002-11-26 | Procter & Gamble | 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability |
US6329369B1 (en) | 1997-12-04 | 2001-12-11 | Allergan Sales, Inc. | Methods of treating pain and other conditions |
US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
ATE444732T1 (de) * | 2003-08-07 | 2009-10-15 | Allergan Inc | Zusammensetzungen zur abgabe von therapeutika in die augen und verfahren zu ihrer herstellung und verwendung |
RU2008122978A (ru) | 2005-11-09 | 2009-12-20 | Комбинаторкс, Инкорпорейтед (Us) | Способы, композиции и наборы для лечения медицинских состояний |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
US4908387A (en) * | 1988-06-06 | 1990-03-13 | The Regents Of The University Of California | Use of beta2 antagonists in the treatment of inflammatory diseases, in particular, rheumatoid arthritis |
US5077292A (en) * | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
US5112822A (en) * | 1989-10-12 | 1992-05-12 | Allergan, Inc. | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same |
US5021416A (en) * | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
-
1992
- 1992-01-13 US US07/820,329 patent/US5231096A/en not_active Expired - Fee Related
-
1993
- 1993-01-12 DE DE69330090T patent/DE69330090T2/de not_active Expired - Fee Related
- 1993-01-12 AT AT93903433T patent/ATE200222T1/de not_active IP Right Cessation
- 1993-01-12 CA CA002127542A patent/CA2127542C/en not_active Expired - Fee Related
- 1993-01-12 ES ES93903433T patent/ES2157216T3/es not_active Expired - Lifetime
- 1993-01-12 WO PCT/US1993/000264 patent/WO1993013771A1/en active IP Right Grant
- 1993-01-12 EP EP93903433A patent/EP0620732B1/en not_active Expired - Lifetime
- 1993-01-12 AU AU34700/93A patent/AU670064B2/en not_active Ceased
- 1993-01-12 JP JP5512627A patent/JPH07503015A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH07503015A (ja) | 1995-03-30 |
ATE200222T1 (de) | 2001-04-15 |
AU3470093A (en) | 1993-08-03 |
DE69330090T2 (de) | 2001-09-20 |
CA2127542C (en) | 2004-08-03 |
EP0620732B1 (en) | 2001-04-04 |
US5231096A (en) | 1993-07-27 |
DE69330090D1 (de) | 2001-05-10 |
AU670064B2 (en) | 1996-07-04 |
WO1993013771A1 (en) | 1993-07-22 |
EP0620732A1 (en) | 1994-10-26 |
CA2127542A1 (en) | 1993-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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