ES2156899T3 - Nuevo procedimiento de preparacion de ergotioneina. - Google Patents

Nuevo procedimiento de preparacion de ergotioneina.

Info

Publication number
ES2156899T3
ES2156899T3 ES94920514T ES94920514T ES2156899T3 ES 2156899 T3 ES2156899 T3 ES 2156899T3 ES 94920514 T ES94920514 T ES 94920514T ES 94920514 T ES94920514 T ES 94920514T ES 2156899 T3 ES2156899 T3 ES 2156899T3
Authority
ES
Spain
Prior art keywords
ergotioneine
new
substitute
preparation procedure
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94920514T
Other languages
English (en)
Inventor
Jean-Claude Yadan
Jinzhu Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxis Isle of Man Ltd
Original Assignee
Oxis Isle of Man Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26230438&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2156899(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR9307839A external-priority patent/FR2707086A1/fr
Application filed by Oxis Isle of Man Ltd filed Critical Oxis Isle of Man Ltd
Application granted granted Critical
Publication of ES2156899T3 publication Critical patent/ES2156899T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO PROCESO DE PREPARACION DE ERGOTIONEINA. EL PROCESO DE SINTESIS QUIMICA DE LAS DIFERENTES FORMAS OPTICAS DE LA ERGOTIONEINA SE CARACTERIZA EN QUE COMPRENDE ESENCIALMENTE LAS ETAPAS QUE CONSISTEN EN PREPARAR O UTILIZAR UNA SAL DE ESTER DE HISTIDINANALFAR-NALFA-DIMETILADA, SI ES NECESARIO OPTICAMENTE ACTIVO; EN TRATAR ESTE COMPUESTO, POR UN HALOGENOTIONOFORMIATO DE ALKILO, DE ALQUENILO O DE ARILO, EN PRESENCIA DE UNA BASE; Y TRAS LA PROTECCION DEL SUSTITUYENTE AZUFRADO DEL COMPUESTO OBTENIDO, TRANSFORMAR ESTE ULTIMO EN UN COMPUESTO DE TIPO TRIMETILAMONIO, Y EN LIBERAR LA ERGOTIONEINA DESEADA POR SAPONIFICACION O HIDROLISIS ACIDA, SEGUN EL CASO. ESTE PROCESO PROCURA UN MEJOR RENDIMIENTO Y ASEGURA UNA EXCELENTE PUREZA OPTICA.
ES94920514T 1993-06-28 1994-06-27 Nuevo procedimiento de preparacion de ergotioneina. Expired - Lifetime ES2156899T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9307839A FR2707086A1 (fr) 1993-06-28 1993-06-28 Procédé de préparation de l'ergothionéine.
FR9315457A FR2707087B1 (fr) 1993-06-28 1993-12-22 Nouveau procédé de préparation de l'ergothionéine.

Publications (1)

Publication Number Publication Date
ES2156899T3 true ES2156899T3 (es) 2001-08-01

Family

ID=26230438

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94920514T Expired - Lifetime ES2156899T3 (es) 1993-06-28 1994-06-27 Nuevo procedimiento de preparacion de ergotioneina.

Country Status (9)

Country Link
US (1) US5438151A (es)
EP (1) EP0656890B1 (es)
JP (2) JP3840616B2 (es)
AU (1) AU688337B2 (es)
CA (1) CA2143419C (es)
DE (1) DE69426520T2 (es)
ES (1) ES2156899T3 (es)
FR (1) FR2707087B1 (es)
WO (1) WO1995000494A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707087B1 (fr) * 1993-06-28 1995-10-13 Bioxytech Nouveau procédé de préparation de l'ergothionéine.
US6103746A (en) * 1997-02-20 2000-08-15 Oxis International, Inc. Methods and compositions for the protection of mitochondria
US6479533B1 (en) 1997-02-20 2002-11-12 Applied Genetics Incorporated Dermatics Methods and compositions for the protection of mitochondria
EP1051165A2 (en) 1998-01-26 2000-11-15 Mitokor Mitochondria protecting agents for treating mitochondria associated diseases
PT1917966E (pt) * 1998-02-13 2010-03-17 Nutramax Lab Inc Agentes e métodos para protecção, tratamento e reparação de tecido conjuntivo
FR2810548A1 (fr) * 2000-06-26 2001-12-28 Oreal Utilisation d'ergothioneine et/ou de ses derives comme agent anti-glycation
US20050042233A1 (en) * 2003-08-21 2005-02-24 Christopher Marrs Stabilized compositions containing an oxygen-labile active agent and a fungal extract
US20050042306A1 (en) * 2003-08-21 2005-02-24 Christopher Marrs Stabilized compositions containing an oxygen-labile active agent
FR2910808B1 (fr) * 2006-12-29 2009-04-10 Lvmh Rech Utilisation en cosmetique de la l-2-thiohistidine ou d'un de ses derives comme agent depigmentant.
EP2134198A4 (en) * 2007-03-07 2012-08-29 Robert B Beelman USE OF ERGOTHIONEIN AS A PRESERVATIVE IN FOOD AND BEVERAGES
US7767826B2 (en) * 2007-10-05 2010-08-03 Pharmatech International, Inc. Process for the synthesis of L-(+)-ergothioneine
US8933245B2 (en) 2009-01-30 2015-01-13 Elc Management Llc Preservation of ergothioneine
US8410156B2 (en) * 2009-01-30 2013-04-02 Elc Management, Llc Preservation of ergothioneine
FR2950889B1 (fr) * 2009-10-06 2011-11-18 Tetrahedron Procede de synthese de l'ergothioneine et analogues
FR2950890B1 (fr) 2009-10-06 2011-12-30 Tetrahedron Procede de synthese de la 2-thiohistidine et analogues
EP3137611B1 (en) 2014-04-29 2021-02-24 Conagen Inc. Microbial ergothioneine biosynthesis
US11390897B2 (en) 2014-12-22 2022-07-19 National University Corporation Okayama University Method for producing ergothioneine
EP3268354B1 (en) 2015-03-13 2020-05-06 Mironova Innovations, LLC Nalpha, nalpha, nalpha-trialkyl histidine derivatives useful for the preparation of ergothioneine compounds
JP6948453B2 (ja) 2018-02-23 2021-10-13 長瀬産業株式会社 エルゴチオネインの製造方法
CA3145979A1 (en) 2019-07-10 2021-01-14 Kureha Corporation Plant growth regulator and method for promoting plant growth
JPWO2021132655A1 (es) 2019-12-27 2021-07-01
WO2022185872A1 (ja) 2021-03-01 2022-09-09 長瀬産業株式会社 エルゴチオネインの製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707087B1 (fr) * 1993-06-28 1995-10-13 Bioxytech Nouveau procédé de préparation de l'ergothionéine.

Also Published As

Publication number Publication date
CA2143419A1 (en) 1995-01-05
AU7127694A (en) 1995-01-17
CA2143419C (en) 2006-01-24
DE69426520T2 (de) 2001-07-12
JP3840616B2 (ja) 2006-11-01
EP0656890B1 (fr) 2001-01-03
DE69426520D1 (de) 2001-02-08
EP0656890A1 (fr) 1995-06-14
WO1995000494A1 (fr) 1995-01-05
JP2006160748A (ja) 2006-06-22
FR2707087B1 (fr) 1995-10-13
US5438151A (en) 1995-08-01
JPH08501575A (ja) 1996-02-20
FR2707087A1 (fr) 1995-01-06
AU688337B2 (en) 1998-03-12

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