ES2155349B1 - Procedimiento de preparacion de un antibiotico de cefalosporina oralmente activo, cefixime. - Google Patents
Procedimiento de preparacion de un antibiotico de cefalosporina oralmente activo, cefixime.Info
- Publication number
- ES2155349B1 ES2155349B1 ES009802177A ES9802177A ES2155349B1 ES 2155349 B1 ES2155349 B1 ES 2155349B1 ES 009802177 A ES009802177 A ES 009802177A ES 9802177 A ES9802177 A ES 9802177A ES 2155349 B1 ES2155349 B1 ES 2155349B1
- Authority
- ES
- Spain
- Prior art keywords
- cefixime
- antibiotic
- orbally
- cefalosporine
- active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229960002129 cefixime Drugs 0.000 title abstract 4
- 230000003115 biocidal effect Effects 0.000 title abstract 3
- OKBVVJOGVLARMR-QSWIMTSFSA-N cefixime Chemical compound S1C(N)=NC(C(=N\OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-QSWIMTSFSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 229930186147 Cephalosporin Natural products 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 229940124587 cephalosporin Drugs 0.000 abstract 2
- 150000001780 cephalosporins Chemical class 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Procedimiento de preparación de un antibiótico de cefalosporina oralmente activo, Cefixime. La presente invención se refiere a un procedimiento para la preparación de antibiótico de cefalosporina oralmente activo - Cefixime, de fórmula I en el que, a temperatura ambiente y durante 30 a 90 minutos se hace reaccionar el éster de la fórmula II en disolvente orgánico con solución acuosa de base inorgánica en presencia de un catalizador de transferencia de fase, permitiendo que la mezcla resultante se asiente hasta la separación de las fases acuosa y orgánica, aislando el Cefixime de la pureza requerida, por acidificación y a partir de la fase acuosa.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT102062A PT102062B (pt) | 1997-10-08 | 1997-10-08 | Processo de preparacao de um antibiotico cefalosporina oralmente activo-cefixime |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2155349A1 ES2155349A1 (es) | 2001-05-01 |
| ES2155349B1 true ES2155349B1 (es) | 2001-12-01 |
Family
ID=20085703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES009802177A Expired - Fee Related ES2155349B1 (es) | 1997-10-08 | 1998-10-08 | Procedimiento de preparacion de un antibiotico de cefalosporina oralmente activo, cefixime. |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE19846449A1 (es) |
| ES (1) | ES2155349B1 (es) |
| GB (1) | GB2330141A (es) |
| PT (1) | PT102062B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6800755B2 (en) * | 2002-10-24 | 2004-10-05 | Orchid Chemicals And Pharmaceuticals Limited | Process for the preparation of cefixime |
| WO2006067806A1 (en) * | 2004-12-21 | 2006-06-29 | Lupin Limited | Process for the preparation of cefixime |
| EP1863822B1 (en) | 2005-03-29 | 2009-10-14 | Hetero Drugs Limited | An improved process for the preparation of cefixime |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9424847D0 (en) * | 1994-12-09 | 1995-02-08 | Smithkline Beecham Plc | Novel process |
-
1997
- 1997-10-08 PT PT102062A patent/PT102062B/pt not_active IP Right Cessation
-
1998
- 1998-10-08 ES ES009802177A patent/ES2155349B1/es not_active Expired - Fee Related
- 1998-10-08 DE DE19846449A patent/DE19846449A1/de not_active Withdrawn
- 1998-10-08 GB GB9821967A patent/GB2330141A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PT102062B (pt) | 2000-08-31 |
| PT102062A (pt) | 1998-06-30 |
| DE19846449A1 (de) | 1999-04-15 |
| ES2155349A1 (es) | 2001-05-01 |
| GB2330141A (en) | 1999-04-14 |
| GB9821967D0 (en) | 1998-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20010501 Kind code of ref document: A1 Effective date: 20010501 |
|
| FD1A | Patent lapsed |
Effective date: 20100311 |