ES2152358T3 - Utilizacion de melatonina para la preparacion de formas medicamentosas pulsatiles perorales. - Google Patents

Utilizacion de melatonina para la preparacion de formas medicamentosas pulsatiles perorales.

Info

Publication number
ES2152358T3
ES2152358T3 ES95118939T ES95118939T ES2152358T3 ES 2152358 T3 ES2152358 T3 ES 2152358T3 ES 95118939 T ES95118939 T ES 95118939T ES 95118939 T ES95118939 T ES 95118939T ES 2152358 T3 ES2152358 T3 ES 2152358T3
Authority
ES
Spain
Prior art keywords
pulsatile
peroral
melatonin
drugs
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95118939T
Other languages
English (en)
Inventor
Michael Prof Dittgen
Sabine Dr Fricke
Thomas Dr Graser
Hermann Dr Osterwald
Michael Prof Oettel
Theodor Hermann Prof Lippert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jenapharm GmbH and Co KG
Original Assignee
Jenapharm GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jenapharm GmbH and Co KG filed Critical Jenapharm GmbH and Co KG
Application granted granted Critical
Publication of ES2152358T3 publication Critical patent/ES2152358T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Abstract

SE DESCRIBE LA UTILIZACION DE MELATONINA PARA LA ELABORACION DE FORMAS DE MEDICAMENTOS PULSATILES PERORALES, QUE GARANTIZAN LA SEGURIDAD DE VALOR SANGUINEO EFECTIVO DEL MEDICAMENTO Y, EN COMPARACION CON LOS MEDICAMENTOS QUE CONTIENEN MELATONINA HABITUALES CON LIBERACION CONTROLADA, REALIZAN UNA FASE DE INVASION RELATIVAMENTE CORTA DE MENOS DE DOS HORAS Y DESTRUYEN AL MISMO TIEMPO LOS CONOCIDOS EFECTOS SECUNDARIOS. SE REALIZA UN CONTROL DE LA LIBERACION DE MELATONINA, LIGADA CON LA ADAPTACION EXACTA A LA ENFERMEDAD DETERMINADA CON LA SUBIDA DEL DOLOR O EL PROGRESO DE LA MISMA ENFERMEDAD, QUE PUEDE SER TRATADA DE MANERA TERAPEUTICA Y PROFILACTICA CON MELATONINA COMO SUSTANCIA.
ES95118939T 1994-12-05 1995-12-01 Utilizacion de melatonina para la preparacion de formas medicamentosas pulsatiles perorales. Expired - Lifetime ES2152358T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4443175A DE4443175A1 (de) 1994-12-05 1994-12-05 Neue pulsatile Arzneiform

Publications (1)

Publication Number Publication Date
ES2152358T3 true ES2152358T3 (es) 2001-02-01

Family

ID=6534914

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95118939T Expired - Lifetime ES2152358T3 (es) 1994-12-05 1995-12-01 Utilizacion de melatonina para la preparacion de formas medicamentosas pulsatiles perorales.

Country Status (8)

Country Link
US (1) US6214377B1 (es)
EP (1) EP0719555B1 (es)
AT (1) ATE197400T1 (es)
DE (2) DE4443175A1 (es)
DK (1) DK0719555T3 (es)
ES (1) ES2152358T3 (es)
GR (1) GR3035364T3 (es)
PT (1) PT719555E (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19718012C1 (de) * 1997-04-29 1998-10-08 Jenapharm Gmbh Verfahren zur Herstellung peroral anwendbarer fester Arzneiformen mit gesteuerter Wirkstoffabgabe
US6703412B1 (en) * 2002-09-27 2004-03-09 Holly A. Rosenthal Method of treating sleeplessness with melatonin on an acute basis
US20050129751A1 (en) * 2003-12-16 2005-06-16 Rothenberg Barry E. Drug delivery compositions and methods
WO2005082143A1 (en) * 2004-02-20 2005-09-09 Lifescape Biosciences Incorporated Compositions and methods for sleep regulation
CN101754753A (zh) * 2007-05-24 2010-06-23 纽约市哥伦比亚大学托管会 褪黑素的持久释放配方
WO2012103411A2 (en) 2011-01-28 2012-08-02 Zx Pharma, Llc Controlled-release melatonin composition and related methods
US9532952B2 (en) 2011-01-28 2017-01-03 Physician's Seal, LLC Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2729007A1 (de) * 1977-06-28 1979-01-18 Rainer Dr Med Liedtke Arzneikapsel mit zwei kammern
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
JP2643222B2 (ja) * 1988-02-03 1997-08-20 エーザイ株式会社 多重層顆粒
DE69026269T2 (de) 1989-11-03 1996-12-19 Riker Laboratories Inc Bioadhäsive zusammensetzung und pflaster
GB9022788D0 (en) * 1990-10-19 1990-12-05 Cortecs Ltd Pharmaceutical formulations
US5707652A (en) * 1990-12-04 1998-01-13 State Of Oregon Methods of treating circadian rhythm phase disorders
ES2134789T3 (es) * 1991-05-09 1999-10-16 Neurim Pharma 1991 Composiciones que contienen melatonina.
US5449683A (en) * 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin
DE4319649A1 (de) * 1993-03-18 1994-09-22 Asta Medica Ag Feste Flupirtin enthaltende orale Darreichungsformen mit kontrollierter Wirkstoffabgabe
WO1995003043A1 (en) * 1993-07-26 1995-02-02 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University Sustained release oral compositions containing melatonin

Also Published As

Publication number Publication date
DE4443175A1 (de) 1996-06-13
DE59508839D1 (de) 2000-12-14
ATE197400T1 (de) 2000-11-11
EP0719555A3 (de) 1997-02-26
EP0719555A2 (de) 1996-07-03
GR3035364T3 (en) 2001-05-31
EP0719555B1 (de) 2000-11-08
US6214377B1 (en) 2001-04-10
DK0719555T3 (da) 2000-12-18
PT719555E (pt) 2001-03-30

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