ES2147244T3 - Compuestos activados por glutation s-transferasa. - Google Patents

Compuestos activados por glutation s-transferasa.

Info

Publication number
ES2147244T3
ES2147244T3 ES94930535T ES94930535T ES2147244T3 ES 2147244 T3 ES2147244 T3 ES 2147244T3 ES 94930535 T ES94930535 T ES 94930535T ES 94930535 T ES94930535 T ES 94930535T ES 2147244 T3 ES2147244 T3 ES 2147244T3
Authority
ES
Spain
Prior art keywords
image
compounds
transferasa
glutation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94930535T
Other languages
English (en)
Inventor
Lawrence M Kauvar
Matthew H Lyttle
Apparao Satyam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telik Inc
Original Assignee
Telik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/130,736 external-priority patent/US5545621A/en
Application filed by Telik Inc filed Critical Telik Inc
Application granted granted Critical
Publication of ES2147244T3 publication Critical patent/ES2147244T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/9116—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • G01N2333/91165—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1)
    • G01N2333/91171—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1) with definite EC number (2.5.1.-)
    • G01N2333/91177—Glutathione transferases (2.5.1.18)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)

Abstract

COMPUESTOS DE FORMULA (1) O LAS MIDAS, ESTERES O SALES DE LOS MISMOS, DONDE: L ES UN GRUPO DE EXTRACCION DE ELECTRONES; S{SUP,X} ES S=O, O=S=O, S=NH, HN=S=O,SE=O,O=SE=O,SE=NH, HN=SE=O, S{SUP,+}R{SUP,4} DONDE R{SUP,4} ES ALQUILO (1-6C), O O-C=O O HNC=O; CADA R DE R{SUP,1}, R{SUP,2} Y R{SUP,3} ES INDEPENDIENTEMENTE H O UN SUSTITUYENTE NO INTERFIRIENTE; N ES 0,1 O 2; Y-CO ES SELECCIONADO DEL GRUPO QUE INCLUYE {GA}-GLU, {BE}ASP, GLU,ASP, {GA}-GLUGLY , {BE}-ASPGLY, GLUGLY Y ASPGLY; Y AA{SUB,C} ES UN AMINO ACIDO ENLAZADO A TRAVES DE UNA UNION PEPTIDA AL RESTO DE DICHO COMPUESTO DE FORMULA (1). ESTOS COMPUESTOS SON PROMEDICAMENTOS UTILES PARA EL TRATAMIENTO SELECTIVO DE TEJIDOS OBJETIVO QUE CONTENGAN ISOENZIMAS STRANSFERASA (GST) DE GLUTATIONA, Y QUE ELEVAN SIMULTANEAMENTE LOS NIVELES DE CELULAS PROGENITORAS GM EN LA MEDULA OSEA.
ES94930535T 1993-10-01 1994-09-30 Compuestos activados por glutation s-transferasa. Expired - Lifetime ES2147244T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/130,736 US5545621A (en) 1991-04-29 1993-10-01 Glutathione S-transferase-activated compounds
US08/309,005 US5556942A (en) 1991-04-29 1994-09-19 Glutathione S-transferase-activated compounds

Publications (1)

Publication Number Publication Date
ES2147244T3 true ES2147244T3 (es) 2000-09-01

Family

ID=26828755

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94930535T Expired - Lifetime ES2147244T3 (es) 1993-10-01 1994-09-30 Compuestos activados por glutation s-transferasa.

Country Status (12)

Country Link
US (1) US5556942A (es)
EP (1) EP0721465B1 (es)
JP (3) JP3989534B2 (es)
AT (1) ATE192455T1 (es)
AU (1) AU676618C (es)
CA (1) CA2173130E (es)
DE (1) DE69424298T2 (es)
DK (1) DK0721465T3 (es)
ES (1) ES2147244T3 (es)
GR (1) GR3033226T3 (es)
PT (1) PT721465E (es)
WO (2) WO1995009865A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679643A (en) * 1987-10-13 1997-10-21 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
US5908919A (en) * 1993-10-01 1999-06-01 Terrapin Technologies Urethane mediated, GST specific molecular release systems
DK0831877T3 (da) * 1995-06-07 2005-02-14 Telik Inc Metabolske virkninger af visse glutathionanaloge
US5880097A (en) * 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
CN1307421C (zh) * 1997-08-08 2007-03-28 塞米得肿瘤学美国公司 克服生物及化学治疗抗性的方法与组合物
AU2226599A (en) * 1998-01-21 1999-08-09 Telik, Inc. Methods to identify myelostimulants
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
DE69900841T2 (de) * 1998-01-23 2002-10-02 Newbiotics Inc Durch enzymkatalyse erhaltene therapeutische substanzen.
CN1391486A (zh) 1999-07-22 2003-01-15 新生物公司 治疗对治疗有抗性的肿瘤的方法
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
US6783929B1 (en) 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
US20030212037A1 (en) * 2000-12-21 2003-11-13 Christopher Boyer Use of bvdu for inhibiting the growth of hyperproliferative cells
UA74574C2 (en) * 2000-05-02 2006-01-16 Telik Inc Bis (n,n'-bis(2-halogenethyl)amino)phosphodiamates, a method for producing thereof (variants), a pharmaceutical composition containing them, and a method for the treatment of tumors
US7148058B2 (en) * 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
US7172905B2 (en) 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
EP2500729A1 (en) * 2002-07-05 2012-09-19 The University of Chicago Characterization of biochips containing self-assembled monolayers
TWI323662B (en) * 2002-11-15 2010-04-21 Telik Inc Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy
TW200538149A (en) * 2004-05-20 2005-12-01 Telik Inc Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound
TW200600091A (en) * 2004-05-21 2006-01-01 Telik Inc Sulfonylethyl phosphorodiamidates
US8198247B2 (en) 2004-12-21 2012-06-12 Telik, Inc. Process for and intermediates in the preparation of canfosfamide and its salts
SI1833978T1 (sl) * 2005-01-06 2009-04-30 Telik Inc Tripeptidni in tetrapeptidni tioetri
CN101541743A (zh) * 2006-11-08 2009-09-23 于崇曦 多肽及相关化合物的透皮给药系统
US20080125397A1 (en) * 2006-11-28 2008-05-29 Telik, Inc. 2 (SULFONYL)ETHYL N,N,N',N' tetrakis(2 chloroethyl)phosphorodia
US7655799B2 (en) * 2006-11-29 2010-02-02 Telik, Inc. 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
US7872134B2 (en) * 2007-12-12 2011-01-18 Telik, Inc. 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
CN108084246A (zh) 2009-05-08 2018-05-29 上海泰飞尔生化技术有限公司 多肽和多肽相关化合物的高穿透力前药组合物
CA2786786C (en) 2010-01-11 2017-07-04 Siemens Aktiengesellschaft Direct drive wind turbine with a cooling system
JP5970439B2 (ja) * 2013-09-20 2016-08-17 チョンシー ユー ペプチド及び関連化合物の経皮送達システム
CN113087765B (zh) * 2021-04-02 2022-10-11 中国人民解放军军事科学院军事医学研究院 一种芥子气肽类加合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
WO1990012088A1 (en) * 1989-04-13 1990-10-18 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce MONOCLONAL ANTIBODIES TO HUMAN GLUTATHIONE S TRANSFERASE Pi
JP2919867B2 (ja) * 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤

Also Published As

Publication number Publication date
JP3989534B2 (ja) 2007-10-10
WO1995009865A1 (en) 1995-04-13
AU7962394A (en) 1995-05-01
CA2173130E (en) 2010-05-25
EP0721465A1 (en) 1996-07-17
WO1995009866A1 (en) 1995-04-13
GR3033226T3 (en) 2000-08-31
DE69424298T2 (de) 2000-08-31
CA2173130C (en) 2001-04-17
PT721465E (pt) 2000-10-31
AU676618C (en) 2003-06-12
JPH09506074A (ja) 1997-06-17
JP4025343B2 (ja) 2007-12-19
DE69424298D1 (de) 2000-06-08
US5556942A (en) 1996-09-17
JP2006169254A (ja) 2006-06-29
CA2173130A1 (en) 1995-04-13
EP0721465B1 (en) 2000-05-03
DK0721465T3 (da) 2000-08-14
JP2008056678A (ja) 2008-03-13
AU676618B2 (en) 1997-03-13
ATE192455T1 (de) 2000-05-15

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