ES2143940A1 - Process for the selective preparation of [alpha]-hydroxy acid derivatives - Google Patents

Process for the selective preparation of [alpha]-hydroxy acid derivatives

Info

Publication number
ES2143940A1
ES2143940A1 ES009800415A ES9800415A ES2143940A1 ES 2143940 A1 ES2143940 A1 ES 2143940A1 ES 009800415 A ES009800415 A ES 009800415A ES 9800415 A ES9800415 A ES 9800415A ES 2143940 A1 ES2143940 A1 ES 2143940A1
Authority
ES
Spain
Prior art keywords
hydroxy acid
alpha
acid derivatives
selective preparation
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009800415A
Other languages
Spanish (es)
Other versions
ES2143940B1 (en
Inventor
Bolanos Guzman Juan Fernandez
Moreno Antonia Heredia
Becerra Blanca Felizon
Bejarano Rafael Guillen
Araujo Ana Jimenez
Arcos Rocio Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES9800415A priority Critical patent/ES2143940B1/en
Publication of ES2143940A1 publication Critical patent/ES2143940A1/en
Application granted granted Critical
Publication of ES2143940B1 publication Critical patent/ES2143940B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

The process is based on simply mixing the α-hydroxy acid with alcohols or fatty acids, the addition of solvent and enzyme. The use of lipases makes it possible to obtain, in regioselective form and without catalysts or toxic agents, hydroxy acid esters in exclusively monomeric form. Control of the water content of the medium is of great importance. The products obtained are used as emulsifiers, moisturizing agents, and in various cosmetic and pharmaceutical formulations.
ES9800415A 1998-02-26 1998-02-26 SELECTIVE PREPARATION PROCEDURE OF ALPHA-HYDROXIACID DERIVATIVES. Expired - Fee Related ES2143940B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9800415A ES2143940B1 (en) 1998-02-26 1998-02-26 SELECTIVE PREPARATION PROCEDURE OF ALPHA-HYDROXIACID DERIVATIVES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9800415A ES2143940B1 (en) 1998-02-26 1998-02-26 SELECTIVE PREPARATION PROCEDURE OF ALPHA-HYDROXIACID DERIVATIVES.

Publications (2)

Publication Number Publication Date
ES2143940A1 true ES2143940A1 (en) 2000-05-16
ES2143940B1 ES2143940B1 (en) 2000-12-16

Family

ID=8302929

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9800415A Expired - Fee Related ES2143940B1 (en) 1998-02-26 1998-02-26 SELECTIVE PREPARATION PROCEDURE OF ALPHA-HYDROXIACID DERIVATIVES.

Country Status (1)

Country Link
ES (1) ES2143940B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7863025B2 (en) 2004-10-18 2011-01-04 Chemic Laboratories, Inc. Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids and their use as percutaneous absorption enhancers

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424130A1 (en) * 1989-10-20 1991-04-24 Unichema Chemie B.V. Supported enzyme
EP0506159A1 (en) * 1991-03-19 1992-09-30 Unichema Chemie B.V. Esterification process
WO1994012652A1 (en) * 1992-11-30 1994-06-09 Baxenden Chemicals Limited Enzymatic synthesis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424130A1 (en) * 1989-10-20 1991-04-24 Unichema Chemie B.V. Supported enzyme
EP0506159A1 (en) * 1991-03-19 1992-09-30 Unichema Chemie B.V. Esterification process
WO1994012652A1 (en) * 1992-11-30 1994-06-09 Baxenden Chemicals Limited Enzymatic synthesis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7863025B2 (en) 2004-10-18 2011-01-04 Chemic Laboratories, Inc. Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids and their use as percutaneous absorption enhancers
US8936922B2 (en) 2004-10-18 2015-01-20 Chemsmart, Llc Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids and their use as percutaneous absorption enhancers

Also Published As

Publication number Publication date
ES2143940B1 (en) 2000-12-16

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