ES2141776T3 - Utilizacion de enzima hidrolitica para reducir o impedir los efectos secundarios de la bleomicina. - Google Patents

Utilizacion de enzima hidrolitica para reducir o impedir los efectos secundarios de la bleomicina.

Info

Publication number
ES2141776T3
ES2141776T3 ES94102079T ES94102079T ES2141776T3 ES 2141776 T3 ES2141776 T3 ES 2141776T3 ES 94102079 T ES94102079 T ES 94102079T ES 94102079 T ES94102079 T ES 94102079T ES 2141776 T3 ES2141776 T3 ES 2141776T3
Authority
ES
Spain
Prior art keywords
bleomycin
side effects
prevent
reduce
hydrolytic enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94102079T
Other languages
English (en)
Inventor
Karl Dr Ransberger
Michael W Dr Schedler
Gerhard Dr Stauder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mucos Emulsion GmbH
Original Assignee
Mucos Emulsion GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mucos Emulsion GmbH filed Critical Mucos Emulsion GmbH
Application granted granted Critical
Publication of ES2141776T3 publication Critical patent/ES2141776T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LA UTILIZACION DE AL MENOS UNA ENZIMA HIDROLITICA PARA LA REDUCCION O PREVENCION DE LOS EFECTOS SECUNDARIOS DE LA BLEOMICINA. LA UTILIZACION DE LA ENZIMA HIDROLITICA PERMITE ESPECIALMENTE LA REDUCCION O PREVENCION DE LA TOXICIDAD PULMONAR DE LA BLEOMICINA.
ES94102079T 1994-02-10 1994-02-10 Utilizacion de enzima hidrolitica para reducir o impedir los efectos secundarios de la bleomicina. Expired - Lifetime ES2141776T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP94102079A EP0667164B1 (de) 1994-02-10 1994-02-10 Verwendung hydrolytischer Enzyme zur Verringerung bzw. Vermeidung der Nebenwirkungen von Bleomycin

Publications (1)

Publication Number Publication Date
ES2141776T3 true ES2141776T3 (es) 2000-04-01

Family

ID=8215675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94102079T Expired - Lifetime ES2141776T3 (es) 1994-02-10 1994-02-10 Utilizacion de enzima hidrolitica para reducir o impedir los efectos secundarios de la bleomicina.

Country Status (7)

Country Link
EP (1) EP0667164B1 (es)
AT (1) ATE188121T1 (es)
DE (1) DE59409038D1 (es)
DK (1) DK0667164T3 (es)
ES (1) ES2141776T3 (es)
GR (1) GR3032850T3 (es)
PT (1) PT667164E (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1951822C3 (de) * 1969-10-14 1980-12-11 Kowa Co., Ltd., Nagoya, Aichi (Japan) Pharmazeutisches Präparat zur Krebsbehandlung
FR2665363B1 (fr) * 1990-07-31 1992-12-04 Cayla Composition pharmaceutique comprenant une ou des bleomycines, et une ou des proteines inactivant les bleomycines.

Also Published As

Publication number Publication date
EP0667164A1 (de) 1995-08-16
PT667164E (pt) 2000-04-28
ATE188121T1 (de) 2000-01-15
EP0667164B1 (de) 1999-12-29
DE59409038D1 (de) 2000-02-03
GR3032850T3 (en) 2000-07-31
DK0667164T3 (da) 2000-05-29

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