ES2139616T3 - 1-aminoacetamidopirroles y 1-amino-2-(sustituido)pirroles y su uso para el tratamiento de disfunciones neurodegenerativas. - Google Patents

1-aminoacetamidopirroles y 1-amino-2-(sustituido)pirroles y su uso para el tratamiento de disfunciones neurodegenerativas.

Info

Publication number
ES2139616T3
ES2139616T3 ES93111994T ES93111994T ES2139616T3 ES 2139616 T3 ES2139616 T3 ES 2139616T3 ES 93111994 T ES93111994 T ES 93111994T ES 93111994 T ES93111994 T ES 93111994T ES 2139616 T3 ES2139616 T3 ES 2139616T3
Authority
ES
Spain
Prior art keywords
hydrogen
loweralkyl
halogen
chem
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93111994T
Other languages
English (en)
Inventor
Lawrence Leo Martin
W Raymond Kosley Jr
M Denise Flanagan
Gert Ulrich Kuerzel
Peter Allen Nemoto
David Dr Wettlaufer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2139616T3 publication Critical patent/ES2139616T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA GENERAL I EN LA QUE R1 ES HIDROGENO O ALQUIL INFERIOR; R2 ES HIDROGENO, ALQUIL INFERIOR, HIDROXIALQUIL INFERIOR, ACILOXIALQUIL INFERIOR O ALCOXIALQUIL INFERIOR; R3 ES HIDROGENO O ALQUIL INFERIOR O BIEN R1 Y R2 TOMADAS JUNTAS FORMAN UN ANILLO DE CICLOALQUIL DE ENTRE 3 Y 7 ATOMOS DE CARBONO; R4 ES HIDROGENO, ALQUIL INFERIOR, ARIL O ARILALQUIL INFERIOR; R5 ES HIDROGENO, ALQUIL INFERIOR, ACIL, ARILOXICARBONIL, ALCOXICARBONIL INFERIOR O ARILALCOXICARBONIL INFERIOR; X ES HIDROGENO, HALOGENO, CIANO, ALQUIL INFERIOR, ARIL, ARILALQUIL INFERIOR, HIDROXIALQUIL INFERIOR, ARILHIDROXIALQUIL INFERIOR, AMINOALQUIL INFERIOR, ALQUILAMINOALQUIL INFERIOR, DIALQUILAMINOALQUIL INFERIOR, ARILSULFONIL, ALQUILSULFONIL INFERIOR, M Y N VALEN INDEPENDIENTEMENTE ENTRE 0 Y 5 CON LA CONDICION DE QUE LA SUMA DE M Y N NO EXCEDA DE 5; P ES 0, 1 O 2; Y EN LA QUE LA LINEA PUNTEADA ENTRE EL ANILLO DE PIRROLA Y EL GRUPO DE CARBOXIL REPRESENTA UN ENLACE OPCIONAL; CUANDO DICHO ENLACE ESTA PRESENTE R6 ES HIDROGENO, ALQUIL INFERIOR, HIDROXIDO, ALCOXIDO INFERIOR, AMINO, ALQUILAMINO INFERIOR, DIALQUILAMINO INFERIOR O LA FORMULA II O LA FORMULA III EN DONDE Y ES HIDROGENO, HALOGENO, ALQUIL INFERIOR, ALCOXIDO INFERIOR, HIDROXIDO, TRIFLUOROMETIL O NITRO; O HETEROARIL SELECCIONADO ENTRE LAS FORMULAS IV, V O VI EN DONDE Z ES HIDROGENO, HALOGENO O ALQUIL INFERIOR, CON LA CONDICION DE QUE CUANDO N Y M SEAN CADA UNA DE ELLAS 0 Y QUE CUANDO R2 Y E3 SEAN CADA UNA DE ELLAS HIDROGENO Y R6 SEA FENIL O FENIL SUSTITUIDO Y JUNTO CON EL GRUPO DE CARBONIL ESTE UNIDA EN LA POSICION 2 DEL ANILLO DE PIRROLA, Y NO PUEDE SER HIDROGENO, HALOGENO, TRIFLUOROMETIL O NITRO; ASIMISMO SE PRESENTAN LAS SALES DE ADICION ACIDA FARMACOLOGICAMENTE ACEPTABLES DE LOS COMPUESTOS. LOS COMPUESTOS DE LA INVENCION SON UTILES COMO ANTAGONISTAS PARCIALES DE LA GLICINA Y PARA LA MEJORA DEL APRENDIZAJE Y DE LA MEMORIA EN EL TRATAMIENTO DE DISFUNCIONES DE LA MEMORIA ASOCIADAS CON ENFERMEDADES NEURODEGENERATIVAS Y ESTAN POR LO TANTO INDICADOS PARA EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER Y OTRAS DEMENCIAS SENILES.
ES93111994T 1992-07-30 1993-07-27 1-aminoacetamidopirroles y 1-amino-2-(sustituido)pirroles y su uso para el tratamiento de disfunciones neurodegenerativas. Expired - Lifetime ES2139616T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/922,291 US5274116A (en) 1992-07-30 1992-07-30 1-aminoacetamidopyrroles and 1-aminoacetamido-2-(substituted)pyrroles and related compounds

Publications (1)

Publication Number Publication Date
ES2139616T3 true ES2139616T3 (es) 2000-02-16

Family

ID=25446838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93111994T Expired - Lifetime ES2139616T3 (es) 1992-07-30 1993-07-27 1-aminoacetamidopirroles y 1-amino-2-(sustituido)pirroles y su uso para el tratamiento de disfunciones neurodegenerativas.

Country Status (13)

Country Link
US (5) US5274116A (es)
EP (1) EP0582182B1 (es)
JP (1) JP2959931B2 (es)
KR (1) KR100308097B1 (es)
AT (1) ATE185800T1 (es)
AU (1) AU660398B2 (es)
CA (1) CA2101581A1 (es)
DE (1) DE69326804T2 (es)
DK (1) DK0582182T3 (es)
ES (1) ES2139616T3 (es)
GR (1) GR3032222T3 (es)
MX (1) MX9304590A (es)
NZ (2) NZ280930A (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4019395A (en) * 1994-11-23 1996-06-17 G.D. Searle & Co. Use of amino-isoxazolidone compounds for improvement of implicit memory
US6090841A (en) * 1997-11-21 2000-07-18 Merck & Co., Inc. Substituted pyrrole derivatives as cell adhesion inhibitors
EP1283448B1 (en) * 2001-08-10 2008-11-05 Samsung Electronics Co., Ltd. Electrophotographic organophotoreceptors with charge transport compounds
EP1293837B1 (en) 2001-09-14 2008-10-08 Samsung Electronics Co., Ltd. Electrophotographic organophotoreceptors
US7118839B2 (en) 2001-09-28 2006-10-10 Samsung Electronics Co., Ltd. Electrophotographic organophotoreceptors with novel charge transport materials
US6689523B2 (en) 2001-11-02 2004-02-10 Samsung Electronics Co., Ltd. Electrophotographic organophotoreceptors with novel charge transport compounds
EP1310483B9 (en) 2001-11-09 2006-07-05 Samsung Electronics Co., Ltd. Electrophotographic organophotoreceptors with charge transport compounds
US6905804B2 (en) * 2002-02-08 2005-06-14 Samsung Electronics Co., Ltd. Electrophotographic organophotoreceptors with novel charge transport materials
US6864028B1 (en) 2002-03-28 2005-03-08 Samsung Electronics Co., Ltd. Di-hydrazone based charge transport compounds
US6864025B2 (en) * 2002-03-28 2005-03-08 Samsung Electronics Co., Ltd. Sulfonyldiphenylene-based charge transport compositions
US6835514B2 (en) * 2002-03-28 2004-12-28 Samsung Electronics Co., Ltd. Hydrazone-based charge transport compounds
US6835513B2 (en) * 2002-03-28 2004-12-28 Samsung Electronic Co., Ltd. Carbazole based charge transport compounds
US6815133B2 (en) * 2002-04-12 2004-11-09 Samsung Electronics Co., Ltd. Sulfonyldiphenylene based charge transport compositions
US6964833B2 (en) * 2002-05-31 2005-11-15 Samsung Electronics Co., Ltd. Linked dihydrazone-based charge transport compounds
US6899984B2 (en) * 2002-05-31 2005-05-31 Samsung Electronics Co., Ltd. Linked dihydrazone-based charge transport compounds
US7090953B2 (en) * 2002-10-25 2006-08-15 Samsung Electronics Co., Ltd. Organophotoreceptor with a charge transport compound having an epoxy group
US7029812B2 (en) * 2002-10-25 2006-04-18 Samsung Electronics Co., Ltd. Organophotoreceptor with charge transport compound having an epoxy group
JP2009114123A (ja) * 2007-11-06 2009-05-28 Astellas Pharma Inc ２−アシル−１−アミノピロール化合物の新規製造法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE724854A (es) * 1967-12-06 1969-05-16
US4588727A (en) * 1984-07-02 1986-05-13 Hoechst-Roussel Pharmaceuticals Inc. Intermediates for pyrrolo[1,2-b][1,2,5]triazepines
US4517195A (en) * 1984-07-02 1985-05-14 Hoechst-Roussel Pharmaceuticals Inc. Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions thereof
CA1262904A (en) * 1984-07-02 1989-11-14 Joseph T. Klein Pyrrolo ¬1,2-b| ¬1,2,5|triazepines, a process and intermediates for their preparation and their use as medicaments
US4800203A (en) * 1987-09-24 1989-01-24 Hoechst-Roussel Pharmaceuticals, Inc. Pyrrolo(1,2-b)cinnolines

Also Published As

Publication number Publication date
EP0582182B1 (en) 1999-10-20
ATE185800T1 (de) 1999-11-15
KR100308097B1 (ko) 2001-12-28
KR940005568A (ko) 1994-03-21
DE69326804T2 (de) 2000-04-27
AU660398B2 (en) 1995-06-22
CA2101581A1 (en) 1994-01-31
EP0582182A1 (en) 1994-02-09
GR3032222T3 (en) 2000-04-27
NZ248267A (en) 1996-09-25
AU4424693A (en) 1994-02-03
US5274116A (en) 1993-12-28
DE69326804D1 (de) 1999-11-25
US5428053A (en) 1995-06-27
JPH06184097A (ja) 1994-07-05
US5580987A (en) 1996-12-03
JP2959931B2 (ja) 1999-10-06
US5605925A (en) 1997-02-25
DK0582182T3 (da) 2000-04-25
NZ280930A (en) 1996-09-25
MX9304590A (es) 1994-04-29
US5576446A (en) 1996-11-19

Similar Documents

Publication Publication Date Title
ES2139616T3 (es) 1-aminoacetamidopirroles y 1-amino-2-(sustituido)pirroles y su uso para el tratamiento de disfunciones neurodegenerativas.
DE69032020D1 (de) N-Substituierte 4-Pyrimidinamine und -Pyrimidindiamine, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
HU9302372D0 (en) Non-aromatic heterocyclic compounds containing nitrogen being substituted with substituted benzyl-amino group
DK0616807T3 (da) Benzimidazol anvendelig i behandlingen af forstyrrelser i centralnervesystemet
UA49847C2 (uk) ПОХІДНІ ІМІДАЗОЛУ, ЩО МАЮТЬ СПОРІДНЕНІСТЬ ДО АКТИВНОСТІ <font face="Symbol">a</font>2-РЕЦЕПТОРІВ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ
ES2132284T3 (es) Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
DE69428142T2 (de) Quinolin- oder Quinazolinderivate, deren Herstellung und Verwendung
TW252114B (es)
DE69210849D1 (de) N-(Aryloxyalkyl)heteroaryl-8-Azabicyclo[3.2.1]Octan, Zwischenverbindungen und Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE69300373D1 (de) (1H-Indol-1-yl)-2-(Amino)Acetamide und verwandte (1H-Indol-1-yl)-(Aminoalkyl)Amide, Zwischenprodukte, Verfahren zur Herstellung davon und ihre Verwendung als Arzneimittel.
KR970009570B1 (en) Intermediates of aminobenzoic acid
ATE89553T1 (de) Hydroxy-1,2,3,4-tetrahydroaminoacridine, verfahren fuer ihre herstellung und ihre verwendung als arzneimittel.
GR3025186T3 (en) The use of benzodiazepine compounds for preparing a pharmaceutical composition against CNS disorders related to the excitatory aminoacids
ES2135383T3 (es) Pirido(3,4-b)pirrolo(1,2-e)(1,4,5)oxadiazepinas y compuestos analogos relacionados, un procedimiento para su preparacion y su uso como medicamentos.
ATE130002T1 (de) 1-(pyridinylalkyl)-1h-indole, -indoline und analoge.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 582182

Country of ref document: ES