ES2134953T3 - Capsulas de gelatina que contienen una solucion de acetaminofeno altamente concentrada. - Google Patents
Capsulas de gelatina que contienen una solucion de acetaminofeno altamente concentrada.Info
- Publication number
- ES2134953T3 ES2134953T3 ES94926475T ES94926475T ES2134953T3 ES 2134953 T3 ES2134953 T3 ES 2134953T3 ES 94926475 T ES94926475 T ES 94926475T ES 94926475 T ES94926475 T ES 94926475T ES 2134953 T3 ES2134953 T3 ES 2134953T3
- Authority
- ES
- Spain
- Prior art keywords
- highly concentrated
- soft gel
- gelatin capsules
- capsules containing
- acetaminophene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Abstract
SE DESCRIBE UN METODO PARA AUMENTAR LA SOLUBILIDAD DE ACETAMINOFENO SOLO O EN COMBINACION CON ANTIHISTAMINICOS, ANTITUSIVOS, DESCONGESTIONANTES Y EXPECTORANTES PARA FORMAR UNA SOLUCION CLARA DE ENCAPSULACION EN UN GEL BLANDO. EL ACETAMINOFENO SE SOLUBILIZA SOLO O EN COMBINACION CON LOS INGREDIENTES ANTERIORES MEDIANTE LA MEZCLA CON GLICOL DE POLIETILENO, GLICOL DE PROPILENO, AGUA, POLIVINILPIRROLIDENO Y ACETATO DE POTASIO (O DE SODIO). ESTA INVENCION AUMENTA LA SOLUBILIDAD DEL ACETAMINOFENO PARA OBTENER EL MISMO TAMAÑO DE GEL BLANDO PARA UNA DOSIS DE 325 MG MIENTRAS QUE ACTUALMENTE ESTA DISPONIBLE PARA UN PRODUCTO DE GEL BLANDO DE 250 MG DE DOSIS. EL SISTEMA DE DISOLVENTE DESCRITO ES UTIL PORQUE PROPORCIONA UNA SOLUCION ALTAMENTE CONCENTRADA DE ACETAMINOFENO CAPAZ DE ENCAPSULACION EN UNA CAPSULA LO SUFICIENTEMENTE PEQUEÑA PARA PERMITIR UN FACIL TRAGADO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10246493A | 1993-08-05 | 1993-08-05 | |
US08/263,630 US5505961A (en) | 1993-08-05 | 1994-06-22 | Gelatin capsules containing a highly concentrated acetaminophen solution |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2134953T3 true ES2134953T3 (es) | 1999-10-16 |
Family
ID=26799397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94926475T Expired - Lifetime ES2134953T3 (es) | 1993-08-05 | 1994-08-04 | Capsulas de gelatina que contienen una solucion de acetaminofeno altamente concentrada. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5505961A (es) |
EP (1) | EP0713390B1 (es) |
JP (1) | JP3678745B2 (es) |
KR (1) | KR100341522B1 (es) |
AU (1) | AU701771B2 (es) |
BR (1) | BR9407178A (es) |
CA (1) | CA2168732C (es) |
DE (1) | DE69419019T2 (es) |
ES (1) | ES2134953T3 (es) |
WO (1) | WO1995004527A1 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE398448T1 (de) | 1993-09-28 | 2008-07-15 | Scherer Gmbh R P | Herstellung von weichgelatinekapseln |
GB9325445D0 (en) | 1993-12-13 | 1994-02-16 | Cortecs Ltd | Pharmaceutical formulations |
US5484606A (en) * | 1994-01-24 | 1996-01-16 | The Procter & Gamble Company | Process for reducing the precipitation of difficulty soluble pharmaceutical actives |
US5510389A (en) * | 1994-03-02 | 1996-04-23 | The Procter & Gamble Company | Concentrated acetaminophen solution compositions |
US5660859A (en) * | 1994-12-29 | 1997-08-26 | Mcneil-Ppc, Inc. | Gelling agent for polyethylene glycol |
NZ280610A (en) * | 1994-12-29 | 1997-08-22 | Mcneil Ppc Inc | Soft gelatin-like pharmaceutical carrier: gelled polyethylene glycol and dispersed active agent |
US5641512A (en) * | 1995-03-29 | 1997-06-24 | The Procter & Gamble Company | Soft gelatin capsule compositions |
US5770215A (en) * | 1997-01-06 | 1998-06-23 | Moshyedi; Emil Payman | Multivitamin/vascular occlusion inhibiting composition |
KR100578669B1 (ko) * | 1997-05-29 | 2006-12-07 | 동아제약주식회사 | 우르소데옥시콜린산을함유하는투명연질캅셀 |
US6365180B1 (en) * | 1998-01-20 | 2002-04-02 | Glenn A. Meyer | Oral liquid compositions |
EP1049459B1 (en) | 1998-01-20 | 2009-04-22 | Applied Analytical Industries, Inc. | Oral liquid compositions |
US6846495B2 (en) | 1999-01-11 | 2005-01-25 | The Procter & Gamble Company | Compositions having improved delivery of actives |
US6383515B2 (en) | 1999-05-28 | 2002-05-07 | Sawyer Maryjean | Solvent system for enhancing solubility |
IT1313579B1 (it) * | 1999-07-30 | 2002-09-09 | Acraf | Composizione farmaceutica liquida a base di paracetamolo. |
US20030034458A1 (en) * | 2001-03-30 | 2003-02-20 | Fuji Photo Film Co., Ltd. | Radiation image storage panel |
US7138133B2 (en) | 2001-10-10 | 2006-11-21 | The Procter & Gamble Company | Orally administered liquid compositions |
US7029698B2 (en) * | 2001-11-21 | 2006-04-18 | R.P. Scherer Technologies, Inc. | Acetaminophen compositions |
US7101572B2 (en) * | 2001-12-07 | 2006-09-05 | Unilab Pharmatech, Ltd. | Taste masked aqueous liquid pharmaceutical composition |
US20060088590A1 (en) * | 2004-10-22 | 2006-04-27 | Banner Pharmacaps, Inc. | Non-blooming gelatin and non-gelatin formulations |
US8231896B2 (en) * | 2004-11-08 | 2012-07-31 | R.P. Scherer Technologies, Llc | Non-gelatin soft capsule system |
US20070053868A1 (en) | 2005-03-08 | 2007-03-08 | Banner Pharmacaps, Inc. | Solvent system for enhancing the solubility of pharmaceutical agents |
US8333989B2 (en) * | 2005-10-26 | 2012-12-18 | Banner Pharmacaps, Inc. | Hydrophilic vehicle-based dual controlled release matrix system |
CN100364521C (zh) * | 2005-12-22 | 2008-01-30 | 浙江万联药业有限公司 | 含对乙酰氨基酚的软胶囊组合物 |
WO2008070950A1 (en) * | 2006-12-13 | 2008-06-19 | Laboratoires Mauves Inc. | Pharmaceutical solution formulations for encapsulation into gelatin capsules or other dosage forms |
CN101909601B (zh) | 2008-01-18 | 2013-06-26 | 陶氏环球技术公司 | 使用甲氧基聚乙二醇增强难溶性活性剂的水溶解度的方法 |
US8518439B2 (en) * | 2008-12-03 | 2013-08-27 | Novartis Ag | Liquid therapeutic composition |
US8518438B2 (en) * | 2011-01-14 | 2013-08-27 | Enspire Group, Llc | Highly concentrated liquid acetaminophen solutions |
US8969416B2 (en) * | 2012-03-29 | 2015-03-03 | Enspire Group LLC | Polyvinylpyrrolidone-containing acetaminophen liquid formulations |
PL2961377T3 (pl) | 2013-02-28 | 2020-11-02 | Pf Consumer Healthcare 1 Llc | Zwiększona stabilność nowych ciekłych kompozycji |
US20140275151A1 (en) * | 2013-03-15 | 2014-09-18 | Mahesh Sudhakar BHARATI | Dye free liquid therapeutic solution |
SG11201507369WA (en) * | 2013-03-15 | 2015-10-29 | Novartis Consumer Health Inc | Dye free liquid therapeutic solution |
WO2016084099A1 (en) * | 2014-11-25 | 2016-06-02 | Biological E Limited | Soft gelatin capsule composition of anti-tussive agents |
US10188133B2 (en) | 2015-04-23 | 2019-01-29 | Basf Se | Gel capsule containing sterol and solubilising agent |
MX2020012233A (es) | 2018-05-16 | 2021-01-29 | Bayer Healthcare Llc | Formula de suspension de alta concentracion para medicamentos en capsula de gel blanda para resfriado y gripe. |
KR102050069B1 (ko) * | 2019-03-29 | 2019-11-28 | (주)알피바이오 | 안정성이 향상된 연질캡슐 제제용 충진조성물 및 이를 포함하는 연질캡슐 제제 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3956490A (en) * | 1972-05-22 | 1976-05-11 | Interx Research Corporation | Administration of alkaline earth metal salts of salicylamide |
US4708834A (en) * | 1986-05-01 | 1987-11-24 | Pharmacaps, Inc. | Preparation of gelatin-encapsulated controlled release composition |
US5071643A (en) * | 1986-10-17 | 1991-12-10 | R. P. Scherer Corporation | Solvent system enhancing the solubility of pharmaceuticals for encapsulation |
-
1994
- 1994-06-22 US US08/263,630 patent/US5505961A/en not_active Expired - Lifetime
- 1994-08-04 BR BR9407178A patent/BR9407178A/pt not_active Application Discontinuation
- 1994-08-04 ES ES94926475T patent/ES2134953T3/es not_active Expired - Lifetime
- 1994-08-04 DE DE69419019T patent/DE69419019T2/de not_active Expired - Lifetime
- 1994-08-04 CA CA002168732A patent/CA2168732C/en not_active Expired - Lifetime
- 1994-08-04 EP EP94926475A patent/EP0713390B1/en not_active Expired - Lifetime
- 1994-08-04 KR KR1019960700592A patent/KR100341522B1/ko not_active IP Right Cessation
- 1994-08-04 WO PCT/US1994/008790 patent/WO1995004527A1/en active IP Right Grant
- 1994-08-04 AU AU76299/94A patent/AU701771B2/en not_active Ceased
- 1994-08-04 JP JP50650795A patent/JP3678745B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR100341522B1 (ko) | 2002-11-23 |
BR9407178A (pt) | 1996-09-17 |
DE69419019T2 (de) | 1999-11-11 |
CA2168732A1 (en) | 1995-02-16 |
JPH09503495A (ja) | 1997-04-08 |
AU701771B2 (en) | 1999-02-04 |
CA2168732C (en) | 1999-10-12 |
KR960703576A (ko) | 1996-08-31 |
EP0713390B1 (en) | 1999-06-09 |
JP3678745B2 (ja) | 2005-08-03 |
DE69419019D1 (de) | 1999-07-15 |
AU7629994A (en) | 1995-02-28 |
WO1995004527A1 (en) | 1995-02-16 |
US5505961A (en) | 1996-04-09 |
EP0713390A1 (en) | 1996-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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