ES2131001A1 - Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus. - Google Patents
Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.Info
- Publication number
- ES2131001A1 ES2131001A1 ES09701305A ES9701305A ES2131001A1 ES 2131001 A1 ES2131001 A1 ES 2131001A1 ES 09701305 A ES09701305 A ES 09701305A ES 9701305 A ES9701305 A ES 9701305A ES 2131001 A1 ES2131001 A1 ES 2131001A1
- Authority
- ES
- Spain
- Prior art keywords
- clavulanic acid
- increasing
- production
- expression
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Procedimiento para incrementar la producción de ácido clavulánico en Streptomyces mediante la sobreexpresión del gen claR. El gen claR caracterizado por la secuencia SEQ ID NO: 2 se encuentra localizado en la agrupación génica que codifica para los genes de biosíntesis de ácido clavulánico y muestra elevada similitud con genes reguladores que actúan como activadores transcripcionales. Mediante técnicas de ADN recombinante se introduce dicho gen en Streptomyces, obteniéndose transformantes que presentan una producción incrementada de ácido clavulánico, con respecto a las cepas control sin transformar. Figura 2.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9701305A ES2131001B1 (es) | 1997-06-16 | 1997-06-16 | Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9701305A ES2131001B1 (es) | 1997-06-16 | 1997-06-16 | Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2131001A1 true ES2131001A1 (es) | 1999-07-01 |
ES2131001B1 ES2131001B1 (es) | 2000-04-01 |
Family
ID=8299694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9701305A Expired - Fee Related ES2131001B1 (es) | 1997-06-16 | 1997-06-16 | Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2131001B1 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001021779A3 (en) * | 1999-09-17 | 2001-12-13 | Dsm Nv | Penicillium chrysogenum transcriptional activator blar, a pathway specific regulator of beta-lactam biosynthesis, and uses therof |
EP1218486A4 (en) * | 1999-09-16 | 2002-11-04 | Univ Johns Hopkins | IMPROVEMENT OF CLAVULIC ACID PRODUCTION |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0349121A2 (en) * | 1988-06-02 | 1990-01-03 | Beecham Group Plc | Method for producing clavulanic acid |
WO1994018326A2 (en) * | 1993-02-02 | 1994-08-18 | Smithkline Beecham Plc | Regulatory gene for clavulanic acid biosynthesis |
CA2108113A1 (en) * | 1993-10-08 | 1995-04-09 | Susan E. Jensen | Dna sequence encoding enzymes of clavulanic acid biosynthesis |
-
1997
- 1997-06-16 ES ES9701305A patent/ES2131001B1/es not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0349121A2 (en) * | 1988-06-02 | 1990-01-03 | Beecham Group Plc | Method for producing clavulanic acid |
WO1994018326A2 (en) * | 1993-02-02 | 1994-08-18 | Smithkline Beecham Plc | Regulatory gene for clavulanic acid biosynthesis |
CA2108113A1 (en) * | 1993-10-08 | 1995-04-09 | Susan E. Jensen | Dna sequence encoding enzymes of clavulanic acid biosynthesis |
Non-Patent Citations (2)
Title |
---|
PÉREZ-LLARENA, F.J. et al., "A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: Amplification results in overproduction of both B-lactam compounds". JOURNAL OF BACTERIOLOGY, 1997, Vol. 179, no 6, paginas 2053-2059 * |
WARD, J.M. et al., "The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces". FEMS MICROBIOLOGY LETTERS, 1993, Vol. 110, paginas 239-242 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1218486A4 (en) * | 1999-09-16 | 2002-11-04 | Univ Johns Hopkins | IMPROVEMENT OF CLAVULIC ACID PRODUCTION |
WO2001021779A3 (en) * | 1999-09-17 | 2001-12-13 | Dsm Nv | Penicillium chrysogenum transcriptional activator blar, a pathway specific regulator of beta-lactam biosynthesis, and uses therof |
Also Published As
Publication number | Publication date |
---|---|
ES2131001B1 (es) | 2000-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990701 Kind code of ref document: A1 Effective date: 19990701 |
|
FD1A | Patent lapsed |
Effective date: 20070618 |