ES2131001A1 - Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus. - Google Patents

Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.

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Publication number
ES2131001A1
ES2131001A1 ES09701305A ES9701305A ES2131001A1 ES 2131001 A1 ES2131001 A1 ES 2131001A1 ES 09701305 A ES09701305 A ES 09701305A ES 9701305 A ES9701305 A ES 9701305A ES 2131001 A1 ES2131001 A1 ES 2131001A1
Authority
ES
Spain
Prior art keywords
clavulanic acid
increasing
production
expression
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09701305A
Other languages
English (en)
Other versions
ES2131001B1 (es
Inventor
Redondo Maria Rosario Perez
Garcia Antonio Rodriguez
Martin Juan Francisco Martin
Duran Encarnacion Mellado
Garcia Bruno Diez
Maldonado Francisco Salto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antibioticos SA
Original Assignee
Antibioticos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Antibioticos SA filed Critical Antibioticos SA
Priority to ES9701305A priority Critical patent/ES2131001B1/es
Publication of ES2131001A1 publication Critical patent/ES2131001A1/es
Application granted granted Critical
Publication of ES2131001B1 publication Critical patent/ES2131001B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

Procedimiento para incrementar la producción de ácido clavulánico en Streptomyces mediante la sobreexpresión del gen claR. El gen claR caracterizado por la secuencia SEQ ID NO: 2 se encuentra localizado en la agrupación génica que codifica para los genes de biosíntesis de ácido clavulánico y muestra elevada similitud con genes reguladores que actúan como activadores transcripcionales. Mediante técnicas de ADN recombinante se introduce dicho gen en Streptomyces, obteniéndose transformantes que presentan una producción incrementada de ácido clavulánico, con respecto a las cepas control sin transformar. Figura 2.
ES9701305A 1997-06-16 1997-06-16 Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus. Expired - Fee Related ES2131001B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9701305A ES2131001B1 (es) 1997-06-16 1997-06-16 Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9701305A ES2131001B1 (es) 1997-06-16 1997-06-16 Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.

Publications (2)

Publication Number Publication Date
ES2131001A1 true ES2131001A1 (es) 1999-07-01
ES2131001B1 ES2131001B1 (es) 2000-04-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES9701305A Expired - Fee Related ES2131001B1 (es) 1997-06-16 1997-06-16 Procedimiento para incrementar la produccion de acido clavulanico mediante la expresion de genes reguladores y biosinteticos de streptomyces clavuligerus.

Country Status (1)

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ES (1) ES2131001B1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021779A3 (en) * 1999-09-17 2001-12-13 Dsm Nv Penicillium chrysogenum transcriptional activator blar, a pathway specific regulator of beta-lactam biosynthesis, and uses therof
EP1218486A4 (en) * 1999-09-16 2002-11-04 Univ Johns Hopkins IMPROVEMENT OF CLAVULIC ACID PRODUCTION

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0349121A2 (en) * 1988-06-02 1990-01-03 Beecham Group Plc Method for producing clavulanic acid
WO1994018326A2 (en) * 1993-02-02 1994-08-18 Smithkline Beecham Plc Regulatory gene for clavulanic acid biosynthesis
CA2108113A1 (en) * 1993-10-08 1995-04-09 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0349121A2 (en) * 1988-06-02 1990-01-03 Beecham Group Plc Method for producing clavulanic acid
WO1994018326A2 (en) * 1993-02-02 1994-08-18 Smithkline Beecham Plc Regulatory gene for clavulanic acid biosynthesis
CA2108113A1 (en) * 1993-10-08 1995-04-09 Susan E. Jensen Dna sequence encoding enzymes of clavulanic acid biosynthesis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PÉREZ-LLARENA, F.J. et al., "A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: Amplification results in overproduction of both B-lactam compounds". JOURNAL OF BACTERIOLOGY, 1997, Vol. 179, no 6, paginas 2053-2059 *
WARD, J.M. et al., "The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces". FEMS MICROBIOLOGY LETTERS, 1993, Vol. 110, paginas 239-242 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1218486A4 (en) * 1999-09-16 2002-11-04 Univ Johns Hopkins IMPROVEMENT OF CLAVULIC ACID PRODUCTION
WO2001021779A3 (en) * 1999-09-17 2001-12-13 Dsm Nv Penicillium chrysogenum transcriptional activator blar, a pathway specific regulator of beta-lactam biosynthesis, and uses therof

Also Published As

Publication number Publication date
ES2131001B1 (es) 2000-04-01

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