ES2127876T3 - Acidos fosforicos sustituidos. - Google Patents
Acidos fosforicos sustituidos.Info
- Publication number
- ES2127876T3 ES2127876T3 ES94119095T ES94119095T ES2127876T3 ES 2127876 T3 ES2127876 T3 ES 2127876T3 ES 94119095 T ES94119095 T ES 94119095T ES 94119095 T ES94119095 T ES 94119095T ES 2127876 T3 ES2127876 T3 ES 2127876T3
- Authority
- ES
- Spain
- Prior art keywords
- reaction
- diphosphonic acid
- phosphoric acids
- organic amine
- diphosphonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003016 phosphoric acids Chemical class 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- BYOBJKVGOIXVED-UHFFFAOYSA-N (2-phosphonoazepan-2-yl)phosphonic acid Chemical compound OP(O)(=O)C1(P(O)(O)=O)CCCCCN1 BYOBJKVGOIXVED-UHFFFAOYSA-N 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 amine salt Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical compound OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Luminescent Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
SE DESCRIBE UN METODO PARA LA PRODUCCION DE ACIDOS AZACICLOALCANOS2,2-DIFOSFONICOS CON LA FORMULA GENERAL ESPECIFICADA, DONDE N ES UN NUMERO ENTERO ENTRE 2 Y 16, Y ES H, UN ALQUILO O ALQUENILO, ALQUILO SUSTITUIDO, O UN ARILO, DE FORMA QUE EL GRUPO "Y" NO SE MODIFIQUE DURANTE LA REACCION, POR REACCION DE UNA LACTAMA CON UN TRIHALURO FOSFORICO EN PRESENCIA DE UN ACIDO FOSFORICO Y/O AGUA, EN QUE LA MEZCLA DE REACCION TAMBIEN INCLUYE UNA AMINA ORGANICA Y/O UNA SAL DE AMINA ORGANICA, ESTANDO SEGUIDA TAL REACCION POR HIDROLISIS DE LA MEZCLA DE REACCION Y PURIFICACION DEL PRODUCTO DE REACCION PARA OBTENER EL ACIDO DIFOSFONICO. EL METODO VIENE EJEMPLIFICADO POR LA PREPARACION DE ACIDO AZACICLOHEPTANO-2,2-DIFOSFONICO Y ACIDO AZACICLONONANO-2,2-DIFOSFONICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939325113A GB9325113D0 (en) | 1993-12-08 | 1993-12-08 | Substituted phosphonic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2127876T3 true ES2127876T3 (es) | 1999-05-01 |
Family
ID=10746286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94119095T Expired - Lifetime ES2127876T3 (es) | 1993-12-08 | 1994-12-03 | Acidos fosforicos sustituidos. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5659035A (es) |
| EP (1) | EP0657462B1 (es) |
| JP (1) | JPH07196677A (es) |
| AT (1) | ATE175416T1 (es) |
| CA (1) | CA2137490A1 (es) |
| DE (1) | DE69415784T2 (es) |
| ES (1) | ES2127876T3 (es) |
| GB (2) | GB9325113D0 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1188761A1 (en) * | 2000-09-18 | 2002-03-20 | SOLVAY (Société Anonyme) | Novel geminal-diphosphonic acids and their manufacture |
| GB0115824D0 (en) * | 2001-06-28 | 2001-08-22 | Rhodia Cons Spec Ltd | Improved solvent systems |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE121644C (es) * | ||||
| DE2003141A1 (de) * | 1970-01-24 | 1971-07-29 | Bayer Ag | 2-Oxo-dihydrochinolin-thionophosphor(phosphon)-saeureester und Verfahren zu ihrer Herstellung |
| DE2343196C3 (de) * | 1973-08-27 | 1980-01-10 | Henkel Kgaa, 4000 Duesseldorf | Aiacycloalkan-2^-diphosphonsäuren oder deren wasserlösliche Salze |
| DE2541981A1 (de) * | 1975-09-20 | 1977-03-24 | Bayer Ag | Verfahren zur herstellung von azacycloalkandiphosphonsaeuren |
| DE3808074A1 (de) * | 1988-03-11 | 1989-09-21 | Henkel Kgaa | Verfahren zur herstellung von azacycloalkan-2,2-diphosphonsaeuren |
| DE4114586A1 (de) * | 1991-05-04 | 1992-11-05 | Boehringer Mannheim Gmbh | Arzneimittel enthaltend azacyclodiphosphonsaeurederivate, neue azacyclodiphosphonsaeurederivate sowie verfahren zu deren herstellung |
-
1993
- 1993-12-08 GB GB939325113A patent/GB9325113D0/en active Pending
-
1994
- 1994-12-02 GB GB9424356A patent/GB2284604B/en not_active Expired - Lifetime
- 1994-12-03 AT AT94119095T patent/ATE175416T1/de not_active IP Right Cessation
- 1994-12-03 EP EP94119095A patent/EP0657462B1/en not_active Expired - Lifetime
- 1994-12-03 DE DE69415784T patent/DE69415784T2/de not_active Expired - Fee Related
- 1994-12-03 ES ES94119095T patent/ES2127876T3/es not_active Expired - Lifetime
- 1994-12-06 JP JP6302070A patent/JPH07196677A/ja active Pending
- 1994-12-07 CA CA002137490A patent/CA2137490A1/en not_active Abandoned
- 1994-12-08 US US08/351,752 patent/US5659035A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB2284604A (en) | 1995-06-14 |
| ATE175416T1 (de) | 1999-01-15 |
| EP0657462A1 (en) | 1995-06-14 |
| EP0657462B1 (en) | 1999-01-07 |
| DE69415784T2 (de) | 1999-06-24 |
| DE69415784D1 (de) | 1999-02-18 |
| JPH07196677A (ja) | 1995-08-01 |
| CA2137490A1 (en) | 1995-06-09 |
| GB2284604B (en) | 1997-08-20 |
| GB9325113D0 (en) | 1994-02-09 |
| GB9424356D0 (en) | 1995-01-18 |
| US5659035A (en) | 1997-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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