ES2127527T3 - Ciclodextrinas polianionicas esterificadas como inhibidores de la proliferacion de las celulas de la musculatura lisa. - Google Patents

Ciclodextrinas polianionicas esterificadas como inhibidores de la proliferacion de las celulas de la musculatura lisa.

Info

Publication number
ES2127527T3
ES2127527T3 ES95918928T ES95918928T ES2127527T3 ES 2127527 T3 ES2127527 T3 ES 2127527T3 ES 95918928 T ES95918928 T ES 95918928T ES 95918928 T ES95918928 T ES 95918928T ES 2127527 T3 ES2127527 T3 ES 2127527T3
Authority
ES
Spain
Prior art keywords
esterified
proliferation
smooth muscle
cyclodextrin
polyionionic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95918928T
Other languages
English (en)
Inventor
Richard Michael Soll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2127527T3 publication Critical patent/ES2127527T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

ESTA INVENCION SE REFIERE A CICLODEXTRINAS POLISULFATADAS ESTERIFICADAS, A SU USO EN EL TRATAMIENTO DE TRASTORNOS Y CONDICIONES QUE ESTAN CARACTERIZADOS POR EXCESIVA PROLIFERACION DE CELULA DEL MUSCULO BLANDO (SCM) COMO RESTENOSIS Y A UNA COMPOSICION FARMACEUTICA DE LAS MISMAS. LAS COMPOSICIONES UTILES EN ESTA INVENCION ESTAN REPRESENTADAS POR LA FORMULA (I), DONDE: M ES UN CATION FARMACEUTICAMENTE ACEPTABLE; P ES 1 O 2; Q ES N/2 CUANDO P ES 2 Y Q ES N CUANDO P ES 1; R SE SELECCIONA DEL GRUPO QUE CONSTA DE ALQUILO BAJO C{SUB,1}-C{SUB,12}, CICLOALQUILO C{SUB,3}-C{SUB,12}, Y ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON 1-3 SUSTITUYENTES INDEPENDIENTEMENTE SELECCIONADOS DE HALOGENO, ALQUILO BAJO C{SUB,1}-C{SUB,12} O ALCOXI C{SUB,1}-C{SUB,12}; Y N ES UN ENTERO DE 6-8, QUE REPRESENTA {AL}-CICLODEXTRINA (N = 6), {BE}-CICLODEXTRINA (N = 7), Y {GA}-CICLODEXTRINA (N = 8).
ES95918928T 1994-06-20 1995-05-03 Ciclodextrinas polianionicas esterificadas como inhibidores de la proliferacion de las celulas de la musculatura lisa. Expired - Lifetime ES2127527T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/263,691 US5464827A (en) 1994-06-20 1994-06-20 Esterified polyanionic cyclodextrins as smooth muscle cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
ES2127527T3 true ES2127527T3 (es) 1999-04-16

Family

ID=23002859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95918928T Expired - Lifetime ES2127527T3 (es) 1994-06-20 1995-05-03 Ciclodextrinas polianionicas esterificadas como inhibidores de la proliferacion de las celulas de la musculatura lisa.

Country Status (11)

Country Link
US (1) US5464827A (es)
EP (1) EP0766699B1 (es)
JP (1) JPH10501575A (es)
AT (1) ATE176675T1 (es)
AU (1) AU2466795A (es)
CA (1) CA2193086A1 (es)
DE (1) DE69507808T2 (es)
DK (1) DK0766699T3 (es)
ES (1) ES2127527T3 (es)
GR (1) GR3030133T3 (es)
WO (1) WO1995035322A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760015A (en) * 1988-01-19 1998-06-02 The Trustees Of The University Of Pennsylvania Cyclodextrin compounds and methods of making and use thereof
BE1008978A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
FR2741079B1 (fr) * 1995-11-13 1997-12-26 Oreal Nouveaux composes, derives de cyclodextrine et leur utilisation, notamment en cosmetique
US5834446A (en) * 1996-06-21 1998-11-10 Queen's University At Kingston Nerve process growth modulators
AUPO888497A0 (en) * 1997-09-01 1997-09-25 Australian National University, The Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
US7132402B2 (en) * 1998-11-24 2006-11-07 Wyeth Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6291434B1 (en) 1998-11-24 2001-09-18 American Home Products Corp. Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
US6340670B1 (en) 1998-11-24 2002-01-22 American Home Products Corporation Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6258784B1 (en) 1998-11-24 2001-07-10 American Home Products Corp. Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6187755B1 (en) 1998-11-24 2001-02-13 American Home Products Corporation Benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6339064B1 (en) 1998-11-24 2002-01-15 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
US7081448B2 (en) * 1998-11-24 2006-07-25 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
US6451767B1 (en) 1998-11-24 2002-09-17 Wyeth Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
US6664243B1 (en) 1998-11-24 2003-12-16 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
US6362170B1 (en) 1998-11-24 2002-03-26 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
EP2124948B1 (en) 2007-02-21 2017-07-26 NC bit, Inc. Compositions for treating hyperproliferative vascular disorders and cancers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019562A (en) * 1988-01-19 1991-05-28 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Growth inhibiting agent and the use thereof
JPH04346932A (ja) * 1991-05-22 1992-12-02 Tanabe Seiyaku Co Ltd シクロデキストリン誘導体のポリ硫酸エステル及びその製法
BR9206736A (pt) * 1991-11-11 1995-10-31 Univ Pennsylvania Composição para afetar o crescimento de tecido vivo em mamíferos processos para promover a angiogenese em mamíferos para tratar tecido transplantado ou órgãos em mamíferos e para tratar osso danificado ou transplantado

Also Published As

Publication number Publication date
GR3030133T3 (en) 1999-07-30
CA2193086A1 (en) 1995-12-28
ATE176675T1 (de) 1999-02-15
DE69507808D1 (de) 1999-03-25
AU2466795A (en) 1996-01-15
WO1995035322A1 (en) 1995-12-28
EP0766699B1 (en) 1999-02-10
JPH10501575A (ja) 1998-02-10
US5464827A (en) 1995-11-07
EP0766699A1 (en) 1997-04-09
DE69507808T2 (de) 1999-09-09
DK0766699T3 (da) 1999-09-20

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