ATE176675T1 - Veresterte, polyanionische cyclodextrine als inhibitoren zur glatten muskelzellenproliferation - Google Patents

Veresterte, polyanionische cyclodextrine als inhibitoren zur glatten muskelzellenproliferation

Info

Publication number
ATE176675T1
ATE176675T1 AT95918928T AT95918928T ATE176675T1 AT E176675 T1 ATE176675 T1 AT E176675T1 AT 95918928 T AT95918928 T AT 95918928T AT 95918928 T AT95918928 T AT 95918928T AT E176675 T1 ATE176675 T1 AT E176675T1
Authority
AT
Austria
Prior art keywords
esterified
smooth muscle
muscle cell
cyclodextrins
cyclodextrin
Prior art date
Application number
AT95918928T
Other languages
English (en)
Inventor
Richard Michael Soll
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE176675T1 publication Critical patent/ATE176675T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
AT95918928T 1994-06-20 1995-05-03 Veresterte, polyanionische cyclodextrine als inhibitoren zur glatten muskelzellenproliferation ATE176675T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/263,691 US5464827A (en) 1994-06-20 1994-06-20 Esterified polyanionic cyclodextrins as smooth muscle cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
ATE176675T1 true ATE176675T1 (de) 1999-02-15

Family

ID=23002859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95918928T ATE176675T1 (de) 1994-06-20 1995-05-03 Veresterte, polyanionische cyclodextrine als inhibitoren zur glatten muskelzellenproliferation

Country Status (11)

Country Link
US (1) US5464827A (de)
EP (1) EP0766699B1 (de)
JP (1) JPH10501575A (de)
AT (1) ATE176675T1 (de)
AU (1) AU2466795A (de)
CA (1) CA2193086A1 (de)
DE (1) DE69507808T2 (de)
DK (1) DK0766699T3 (de)
ES (1) ES2127527T3 (de)
GR (1) GR3030133T3 (de)
WO (1) WO1995035322A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760015A (en) * 1988-01-19 1998-06-02 The Trustees Of The University Of Pennsylvania Cyclodextrin compounds and methods of making and use thereof
BE1008978A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
FR2741079B1 (fr) * 1995-11-13 1997-12-26 Oreal Nouveaux composes, derives de cyclodextrine et leur utilisation, notamment en cosmetique
US5834446A (en) * 1996-06-21 1998-11-10 Queen's University At Kingston Nerve process growth modulators
AUPO888497A0 (en) * 1997-09-01 1997-09-25 Australian National University, The Use of sulfated oligosaccharides as inhibitors of cardiovascular disease
US7132402B2 (en) * 1998-11-24 2006-11-07 Wyeth Acylated benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6291434B1 (en) 1998-11-24 2001-09-18 American Home Products Corp. Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
US6340670B1 (en) 1998-11-24 2002-01-22 American Home Products Corporation Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6258784B1 (en) 1998-11-24 2001-07-10 American Home Products Corp. Acetal benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6187755B1 (en) 1998-11-24 2001-02-13 American Home Products Corporation Benzylmaltosides as inhibitors of smooth muscle cell proliferation
US6339064B1 (en) 1998-11-24 2002-01-15 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
US7081448B2 (en) * 1998-11-24 2006-07-25 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
US6451767B1 (en) 1998-11-24 2002-09-17 Wyeth Benzylmaltotriosides as inhibitors of smooth muscle cell proliferation
US6664243B1 (en) 1998-11-24 2003-12-16 Wyeth Benzyllactobionamides as inhibitors of smooth muscle cell proliferation
US6362170B1 (en) 1998-11-24 2002-03-26 American Home Products Corporation Benzylglycosylamides as inhibitors of smooth muscle cell proliferation
EP2124948B1 (de) 2007-02-21 2017-07-26 NC bit, Inc. Zusammensetzungen zur behandlung von hyperproliferativen gefässerkrankungen und krebserkrankungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019562A (en) * 1988-01-19 1991-05-28 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Growth inhibiting agent and the use thereof
JPH04346932A (ja) * 1991-05-22 1992-12-02 Tanabe Seiyaku Co Ltd シクロデキストリン誘導体のポリ硫酸エステル及びその製法
BR9206736A (pt) * 1991-11-11 1995-10-31 Univ Pennsylvania Composição para afetar o crescimento de tecido vivo em mamíferos processos para promover a angiogenese em mamíferos para tratar tecido transplantado ou órgãos em mamíferos e para tratar osso danificado ou transplantado

Also Published As

Publication number Publication date
GR3030133T3 (en) 1999-07-30
CA2193086A1 (en) 1995-12-28
DE69507808D1 (de) 1999-03-25
AU2466795A (en) 1996-01-15
WO1995035322A1 (en) 1995-12-28
EP0766699B1 (de) 1999-02-10
JPH10501575A (ja) 1998-02-10
ES2127527T3 (es) 1999-04-16
US5464827A (en) 1995-11-07
EP0766699A1 (de) 1997-04-09
DE69507808T2 (de) 1999-09-09
DK0766699T3 (da) 1999-09-20

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