ES2120368A1 - Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables. - Google Patents

Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables.

Info

Publication number
ES2120368A1
ES2120368A1 ES09601339A ES9601339A ES2120368A1 ES 2120368 A1 ES2120368 A1 ES 2120368A1 ES 09601339 A ES09601339 A ES 09601339A ES 9601339 A ES9601339 A ES 9601339A ES 2120368 A1 ES2120368 A1 ES 2120368A1
Authority
ES
Spain
Prior art keywords
phenylpropylamine
trifluoromethylphenoxy
methyl
obtaining
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09601339A
Other languages
English (en)
Other versions
ES2120368B1 (es
Inventor
Cruz Alba Agusti
Fabra Carlos Braojos
Seres Marta Perapoch
Vilarelle Eduardo Elias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to ES09601339A priority Critical patent/ES2120368B1/es
Publication of ES2120368A1 publication Critical patent/ES2120368A1/es
Application granted granted Critical
Publication of ES2120368B1 publication Critical patent/ES2120368B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE N-METIL-3-(P-TRIFLUOROMETILFENOXI)-3-FENILPROPILAMINA Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. EL PROCEDIMIENTO PARA OBTENER N-METIL-3-(P-TRIFLUOROMETILFENOXI)-3-FENILPROPILAMINA, DE FORMULA GENERAL (I), SE BASA EN LA REACCION DE ESTERIFICACION DE LOS COMPUESTOS DE FORMULA GENERAL (II) CON 1-HALO-4-TRIFLUORO-METILBENCENO, SIENDO P UN GRUPO PROTECTOR DE AMINAS, TAL COMO ALQUILO O ARILALQUILO. LA REACCION SE VERIFICA EN PRESENCIA DE UN DISOLVENTE POLAR APROTICO Y DE UN CATALIZADOR COMO UNA SAL DE AMONIO CUATERNARIO. EL GRUPO PROTECTOR P SE ELIMINA POSTERIORMENTE POR REACCION CON 1-CLORO-ALQUILCLOROFORMIATOS, PARA DAR EL PRODUCTO (I). EL PRODUCTO (I), CONOCIDO COMO FLUOXETINA, POSEE ACTIVIDAD COMO ANTIDEPRESIVO.
ES09601339A 1996-06-14 1996-06-14 Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables. Expired - Fee Related ES2120368B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES09601339A ES2120368B1 (es) 1996-06-14 1996-06-14 Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601339A ES2120368B1 (es) 1996-06-14 1996-06-14 Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables.

Publications (2)

Publication Number Publication Date
ES2120368A1 true ES2120368A1 (es) 1998-10-16
ES2120368B1 ES2120368B1 (es) 1999-07-01

Family

ID=8295172

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09601339A Expired - Fee Related ES2120368B1 (es) 1996-06-14 1996-06-14 Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables.

Country Status (1)

Country Link
ES (1) ES2120368B1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061540A1 (en) * 1999-04-09 2000-10-19 Eli Lilly And Company Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof
WO2007006132A1 (en) * 2005-07-08 2007-01-18 Apotex Pharmachem Inc. An efficient method for preparing 3-aryloxy-3- arylpropylamines and their optical stereoisomers

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2060618A (en) * 1979-09-14 1981-05-07 Wyeth John & Brother Ltd 3-Aryl-3-Aryloxypropylamines
WO1994000416A1 (en) * 1992-06-26 1994-01-06 Richter Gedeon Vegyészeti Gyár Rt. Preparation of n-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine and acid addition salts thereof
EP0617006A1 (en) * 1993-02-05 1994-09-28 PLIVA d.d. ZAGREB N-subtituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation
ES2062131T3 (es) * 1989-03-03 1994-12-16 Orion Yhtymae Oy Procedimiento para la preparacion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales.
ES2071663T3 (es) * 1988-11-14 1995-07-01 Lilly Co Eli Analogo de fluoxetina.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2060618A (en) * 1979-09-14 1981-05-07 Wyeth John & Brother Ltd 3-Aryl-3-Aryloxypropylamines
ES2071663T3 (es) * 1988-11-14 1995-07-01 Lilly Co Eli Analogo de fluoxetina.
ES2062131T3 (es) * 1989-03-03 1994-12-16 Orion Yhtymae Oy Procedimiento para la preparacion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales.
WO1994000416A1 (en) * 1992-06-26 1994-01-06 Richter Gedeon Vegyészeti Gyár Rt. Preparation of n-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine and acid addition salts thereof
EP0617006A1 (en) * 1993-02-05 1994-09-28 PLIVA d.d. ZAGREB N-subtituted derivatives of N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine and the procedure for their preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RISLEY, D y BOPP, R.J: FLUOXETINE. Analytical Profiles of drug substances. 1990. Vol. 19. Pßginas 193-219 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061540A1 (en) * 1999-04-09 2000-10-19 Eli Lilly And Company Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof
WO2007006132A1 (en) * 2005-07-08 2007-01-18 Apotex Pharmachem Inc. An efficient method for preparing 3-aryloxy-3- arylpropylamines and their optical stereoisomers

Also Published As

Publication number Publication date
ES2120368B1 (es) 1999-07-01

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