ES2117357T3 - Tetrahidrobenz(cd)indoles reguladores de la actividad de la serotonina. - Google Patents

Tetrahidrobenz(cd)indoles reguladores de la actividad de la serotonina.

Info

Publication number
ES2117357T3
ES2117357T3 ES95303268T ES95303268T ES2117357T3 ES 2117357 T3 ES2117357 T3 ES 2117357T3 ES 95303268 T ES95303268 T ES 95303268T ES 95303268 T ES95303268 T ES 95303268T ES 2117357 T3 ES2117357 T3 ES 2117357T3
Authority
ES
Spain
Prior art keywords
regulators
activity
tetrahidrobenz
serotonine
indoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95303268T
Other languages
English (en)
Inventor
Michael Edward Flaugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2117357T3 publication Critical patent/ES2117357T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTA UNA SERIE DE 1,3,4-5TETRAHIDROBENZ[C,D] INDAZOLAS DE LA FORMULA (I) QUE TIENEN ACTIVIDAD COMO REGULADORAS DE LAS FUNCIONES DE LA SEROTONINA, PARTICULARMENTE EN EL CEREBRO.
ES95303268T 1994-05-18 1995-05-16 Tetrahidrobenz(cd)indoles reguladores de la actividad de la serotonina. Expired - Lifetime ES2117357T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/245,316 US5385928A (en) 1994-05-18 1994-05-18 Tetrahydrobenz [CD] indazoles, compositions and use

Publications (1)

Publication Number Publication Date
ES2117357T3 true ES2117357T3 (es) 1998-08-01

Family

ID=22926175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95303268T Expired - Lifetime ES2117357T3 (es) 1994-05-18 1995-05-16 Tetrahidrobenz(cd)indoles reguladores de la actividad de la serotonina.

Country Status (6)

Country Link
US (1) US5385928A (es)
EP (1) EP0683155B1 (es)
JP (1) JPH07309842A (es)
CA (1) CA2149608A1 (es)
DE (1) DE69503186T2 (es)
ES (1) ES2117357T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385928A (en) * 1994-05-18 1995-01-31 Eli Lilly And Company Tetrahydrobenz [CD] indazoles, compositions and use
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
EP1392658A4 (en) * 2001-06-01 2004-10-13 Alcon Inc NOVEL FUSED INDAZOLES AND INDOLES AND THEIR USE IN THE TREATMENT OF GLAUCOMES

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH517732A (de) * 1969-10-24 1972-01-15 Sandoz Ag Verfahren zur Herstellung neuer Guanidin- Verbindungen
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US5026869A (en) * 1984-02-06 1991-06-25 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
US4983622A (en) * 1984-02-06 1991-01-08 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
DE3525564A1 (de) * 1985-07-15 1987-02-05 Schering Ag Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5212319A (en) * 1990-02-26 1993-05-18 Eli Lilly And Company Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor
US5039820A (en) * 1990-02-26 1991-08-13 Eli Lilly And Company 4-amino-6-iodo-hexahydrobenz(cd)indoles
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5229410A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
US5385928A (en) * 1994-05-18 1995-01-31 Eli Lilly And Company Tetrahydrobenz [CD] indazoles, compositions and use

Also Published As

Publication number Publication date
EP0683155A1 (en) 1995-11-22
DE69503186D1 (de) 1998-08-06
EP0683155B1 (en) 1998-07-01
DE69503186T2 (de) 1998-12-10
JPH07309842A (ja) 1995-11-28
US5385928A (en) 1995-01-31
CA2149608A1 (en) 1995-11-19

Similar Documents

Publication Publication Date Title
AR003466A1 (es) Compuestos 14-hidroxi-2-desoxoparahercuamida b
DE69633679D1 (de) Substituierte aryl-oder heteroarylamide mit retinoid-ähnlicher biologischer aktivität
HN1998000143A (es) Tetrahidronaftalenos substituidos y compuestos analogos.
BRPI0414598A (pt) indóis substituìdos
EA200101275A1 (ru) Композиции, содержащие креатин в суспензии
ES2119912T3 (es) Nuevos aminometilenpeptidos como inmunosupresores.
PT695758E (pt) Amidas e esteres de pentapeptidos inibidores de cancro humano
DK0960107T3 (da) 6-Thiosubstituerede paclitaxeler
SV1999000102A (es) Compuestos heterociclicos como inhibidores de enzimas de rotamasa. ref. pcs 9475 afae/bb.
DE69006100D1 (de) Fibronektin-Derivate.
DE69531682D1 (de) Sterolderivate für die regulierung der meiose
NO994877L (no) Kalsilytiske forbindelser
PT1017659E (pt) Tetra-hidronaftalenos substituidos e compostos analogos
DE69839939D1 (de) Tropoelastinderivate
ATE167670T1 (de) N-alkylthiopolyaminderivate als radioprotektive mittel
BG101892A (en) Sugar-modified cytostatics
ATE554173T1 (de) Herstellung von hybridem saatgut
IT1295933B1 (it) 2-(2'-idrossifenil)benzotriazoli e procedimento per la loro preparazione
MX9305093A (es) Nuevos derivadosindano-2 mercaptoacetilamina triciclicos 2-sustituidos, utiles como inhibidores de la encefalinasa.
ME00533B (me) Nova primjena derivata taksoida
RU94038042A (ru) Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент
ES2117357T3 (es) Tetrahidrobenz(cd)indoles reguladores de la actividad de la serotonina.
BR9915514A (pt) Medicamento para abaixar a prolactina.
ES2140672T3 (es) Compuestos biciclicos sustituidos, fusionados y puentes utilizados como agentes terapeuticos.
BR9802803A (pt) ação e composições farmacêuticas contendo os mesmos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 683155

Country of ref document: ES