ES2116719T3 - INTERRUPTED FLOW ANALYSIS DEVICE. - Google Patents

INTERRUPTED FLOW ANALYSIS DEVICE.

Info

Publication number
ES2116719T3
ES2116719T3 ES95904245T ES95904245T ES2116719T3 ES 2116719 T3 ES2116719 T3 ES 2116719T3 ES 95904245 T ES95904245 T ES 95904245T ES 95904245 T ES95904245 T ES 95904245T ES 2116719 T3 ES2116719 T3 ES 2116719T3
Authority
ES
Spain
Prior art keywords
test
analyte
specific union
opposable
absorbent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95904245T
Other languages
Spanish (es)
Inventor
Howard M Chandler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Diagnostics Inc
Original Assignee
SmithKline Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Diagnostics Inc filed Critical SmithKline Diagnostics Inc
Application granted granted Critical
Publication of ES2116719T3 publication Critical patent/ES2116719T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B01L3/5055—Hinged, e.g. opposable surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/30—Control of physical parameters of the fluid carrier of temperature
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/974—Aids related test
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA DISPOSITIVOS DE ENSAYO CROMATOGRAFICO QUE PUEDEN LLEVAR A CABO MULTIPLES ENSAYOS SIMULTANEAMENTE EN LA MISMA TIRA DE PRUEBA, ASI COMO METODOS PARA SU USO. UNO DE LOS ENSAYOS PUEDE SER UN ENSAYO INMUNOLOGICO PARA DETECTAR UN ANTIGENO, COMO GONADOTROPINA CORIONICA HUMANA, MIENTRAS OTRO ENSAYO PUEDE SER UN ENSAYO SEROLOGICO PARA DETECTAR UN ANTICUERPO, COMO UN ANTICUERPO ANTI RUBEOLA. UN DISPOSITIVO DE ENSAYO DE ACUERDO CON LA PRESENTE INVENCION PUEDE COMPRENDER: (1) UN PRIMER COMPONENTE OPONIBLE (12) QUE INCLUYE AL MENOS UN MEDIO CROMATOGRAFICO (24) QUE TIENE UN MIEMBRO DE UNION ESPECIFICO PARA EL PRIMER ANALITO (34) Y UN MIEMBRO DE UNION ESPECIFICO PARA EL SEGUNDO ANALITO INMOVILIZADO ADEMAS EN ZONAS DE NO SOLAPAMIENTO, SEPARADAS, DISCRETAS (36); Y (2) UN SEGUNDO COMPONENTE OPONIBLE (14) QUE INCLUYE UN ABSORBENTE (50). EL PRIMER Y SEGUNDO COMPONENTES OPONIBLES ESTAN CONFIGURADOS DE MODO QUE PONIENDO EL PRIMER Y SEGUNDO COMPONENTES OPONIBLES EN OPOSICION HACEQUE EL ABSORBENTE ENTRE EN CONTACTO OPERABLE CON AL MENOS UN MEDIO CROMATOGRAFICO PARA QUE LA ZONA QUE CONTIENE EL MIEMBRO DE UNION ESPECIFICO PARA EL PRIMER ANALITO ESTE FUNCIONALMENTE DIVIDIDO DESDE LA ZONA QUE CONTIENE EL MIEMBRO DE UNION ESPECIFICO AL SEGUNDO ANALITO DE MODO QUE PUEDAN DETECTARSE AMBOS ANALITOS.THE PRESENT INVENTION PROVIDES CHROMATOGRAPHIC TEST DEVICES THAT MAY CONDUCT MULTIPLE TESTS SIMULTANEOUSLY ON THE SAME TEST STRIP, AS WELL AS METHODS FOR ITS USE. ONE OF THE TESTS MAY BE AN IMMUNOLOGIC TEST TO DETECT AN ANTIGEN, LIKE A HUMAN CHORONIC GONADOTROPIN, WHILE ANOTHER TEST MAY BE A SEROLOGICAL TEST, LIKE AN ANTI RUBELLA ANTIBODY. A TEST DEVICE ACCORDING TO THE PRESENT INVENTION MAY INCLUDE: (1) A FIRST OPPOSABLE COMPONENT (12) THAT INCLUDES AT LEAST ONE CHROMATOGRAPHIC MEDIA (24) THAT HAS A MEMBER OF A SPECIFIC UNION FOR THE FIRST ANALYTE (34) AND A MEMBER OF SPECIFIC UNION FOR THE SECOND ANALYTE IMMOBILIZED IN ADDITION IN NON-OVERLAPPING, SEPARATE, DISCREET ZONES (36); AND (2) A SECOND OPPOSABLE COMPONENT (14) INCLUDING AN ABSORBENT (50). THE FIRST AND SECOND OPPOSABLE COMPONENTS ARE CONFIGURED SO THAT PUTTING THE FIRST AND SECOND OPPOSED COMPONENTS IN OPPOSITION MAKES THE ABSORBENT CONTACT OPERABLE WITH AT LEAST ONE CHROMATOGRAPHIC MEDIA FOR THE AREA CONTAINING THE MEMBER OF A SPECIAL MEMBER. DIVIDED FROM THE ZONE CONTAINING THE SPECIFIC UNION MEMBER TO THE SECOND ANALYTE SO THAT BOTH ANALYTIES CAN BE DETECTED.

ES95904245T 1993-12-07 1994-12-06 INTERRUPTED FLOW ANALYSIS DEVICE. Expired - Lifetime ES2116719T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/163,341 US5468648A (en) 1991-05-29 1993-12-07 Interrupted-flow assay device

Publications (1)

Publication Number Publication Date
ES2116719T3 true ES2116719T3 (en) 1998-07-16

Family

ID=22589610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95904245T Expired - Lifetime ES2116719T3 (en) 1993-12-07 1994-12-06 INTERRUPTED FLOW ANALYSIS DEVICE.

Country Status (9)

Country Link
US (1) US5468648A (en)
EP (1) EP0733211B1 (en)
JP (1) JP3386132B2 (en)
CN (1) CN1137316A (en)
AU (1) AU684585B2 (en)
CA (1) CA2172993A1 (en)
DE (1) DE69410293T2 (en)
ES (1) ES2116719T3 (en)
WO (1) WO1995016208A1 (en)

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US5468648A (en) 1995-11-21
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AU1300895A (en) 1995-06-27
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CA2172993A1 (en) 1995-06-15
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