ES2114498A1 - Nucleos de polilisina ramificados con peptidos relacionados con el virus a de la hepatitis. - Google Patents

Nucleos de polilisina ramificados con peptidos relacionados con el virus a de la hepatitis.

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Publication number
ES2114498A1
ES2114498A1 ES09601399A ES9601399A ES2114498A1 ES 2114498 A1 ES2114498 A1 ES 2114498A1 ES 09601399 A ES09601399 A ES 09601399A ES 9601399 A ES9601399 A ES 9601399A ES 2114498 A1 ES2114498 A1 ES 2114498A1
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ES
Spain
Prior art keywords
hepatitis
virus
nuclei
peptides related
syntheses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09601399A
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English (en)
Other versions
ES2114498B1 (es
Inventor
Villar Isabel Haro
Isart Francisca Reig
Jurado Jose Antonio Perez
Tatiana Firsova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
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Consejo Superior de Investigaciones Cientificas CSIC
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Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES9601399A priority Critical patent/ES2114498B1/es
Publication of ES2114498A1 publication Critical patent/ES2114498A1/es
Application granted granted Critical
Publication of ES2114498B1 publication Critical patent/ES2114498B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NUCLEOS DE POLILISINA RAMIFICADOS CON PEPTIDOS RELACIONADOS CON EL VIRUS A DE LA HEPATITIS. EL OBJETO DE LA PRESENTE INVENCION CONSISTE EN LA SINTESIS DE ESTRUCTURAS PEPTIDICAS RAMIFICADAS FORMADAS POR LAS SECUENCIAS (11-25 Y 110-121) DE LAS PROTEINAS VP1 Y VP3 DE LA CAPSIDE DEL VIRUS DE LA HEPATITIS A, RESPECTIVAMENTE. ESTAS SINTESIS ESTAN BASADAS EN LA FORMACION PREVIA DE UN NUCLEO DE LISINAS (DI, TETRA U OCTAVALENTE) QUE PERMITE, MEDIANTE UNA ESTRATEGIA ADECUADA DE SINTESIS ORTOGONAL, LA INTRODUCCION PASO A PASO DE LOS AMINOACIDOS CONSTITUYENTES DE DOS SECUENCIAS PEPTIDICAS DISTINTAS, OBTENIENDOSE DE ESTE MODO ESTRUCTURAS MACROMOLECULARES HETEROGENEAS. EL OBJETO DE ESTAS SINTESIS TIENE APLICACION EN EL DISEÑO DE VACUNAS QUIMICAS Y/O EN EL DESARROLLO DE SISTEMAS DE DIAGNOSTICO DE LA HEPATITIS A.
ES9601399A 1996-06-21 1996-06-21 Nucleos de polilisina ramificados con peptidos relacionados con el virus a de la hepatitis. Expired - Lifetime ES2114498B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9601399A ES2114498B1 (es) 1996-06-21 1996-06-21 Nucleos de polilisina ramificados con peptidos relacionados con el virus a de la hepatitis.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9601399A ES2114498B1 (es) 1996-06-21 1996-06-21 Nucleos de polilisina ramificados con peptidos relacionados con el virus a de la hepatitis.

Publications (2)

Publication Number Publication Date
ES2114498A1 true ES2114498A1 (es) 1998-05-16
ES2114498B1 ES2114498B1 (es) 1999-02-01

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ID=8295258

Family Applications (1)

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ES9601399A Expired - Lifetime ES2114498B1 (es) 1996-06-21 1996-06-21 Nucleos de polilisina ramificados con peptidos relacionados con el virus a de la hepatitis.

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ES (1) ES2114498B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180244724A1 (en) * 2015-07-15 2018-08-30 Su HAN Polypeptide compound and preparation method and use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HARO, I. et al. "Analysis of the perturbation of phospholipid model membranes by a multiple antigenic peptide." ANAL. CHIM. ACTA. (1995). Vol. 303, n‘ 1. Pßginas 57-64 * Todo el documento * *
P•REZ, J.A. et al. "Solid phase synthesis and immunogenicity of a VP3 peptide from Hepatitis A virus." Biomed. Pept., Proteins Nucleic Acids (1995), Vol. 1, n‘ 2, pßginas 93-100 * Todo el documento * *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180244724A1 (en) * 2015-07-15 2018-08-30 Su HAN Polypeptide compound and preparation method and use thereof

Also Published As

Publication number Publication date
ES2114498B1 (es) 1999-02-01

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