ES2109501T3 - Aparato y metodo para inducir y detectar fluorescencia. - Google Patents
Aparato y metodo para inducir y detectar fluorescencia.Info
- Publication number
- ES2109501T3 ES2109501T3 ES93912658T ES93912658T ES2109501T3 ES 2109501 T3 ES2109501 T3 ES 2109501T3 ES 93912658 T ES93912658 T ES 93912658T ES 93912658 T ES93912658 T ES 93912658T ES 2109501 T3 ES2109501 T3 ES 2109501T3
- Authority
- ES
- Spain
- Prior art keywords
- light
- fluid medium
- detector
- sensor face
- pct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6473—In-line geometry
- G01N2021/6476—Front end, i.e. backscatter, geometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/85—Investigating moving fluids or granular solids
- G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Fluid Pressure (AREA)
Abstract
UN APARATO Y UN METODO PARA INDUCIR Y DETECTAR FLUORESCENCIA EN UN MEDIO FLUIDO QUE CONTIENE AL MENOS UN FLUOROFOR. EL APARATO COMPRENDE UN EMISOR DE LUZ ADAPTADO PARA EMITIR LUZ DE UNA LONGITUD DE ONDA CAPA DE EXCITAR FLUOROFOROS EN EL MEDIO DE FLUIDO, UN DETECTOR DE LUZ ADAPTADO PARA DETECTAR FLUORESCENCIA EMITIDA POR LOS FLUOROFOROS EXCITADOS POR LA LUZ DE EXCITACION, UN CUERPO DETECTOR, QUE ES PREFERENTEMENTE SOLIDO Y HECHO DE CUARZO, QUE TIENE PARTE DE PARED INTERNAMENTE REFLECTANTES CAPACES DE REFLEJAR AL MENOS LUZ QUE TIENE UNA LONGITUD DE ONDA CORRESPONDIENTE A LA LONGITUD DE ONDA DE LA FLUORESCENCIA Y QUE TIENE UNA CARA DETECTORA ADAPTADA PARA SER EXPUESTA AL MEDIO DE FLUIDO, ADAPTANDOSE EL CUERPO DETECTOR PARA RECIBIR LA LUZ DE EXCITACION DEL EMISOR DE LUZ, COMO POR UNA FIBRA OPTICA, Y PARA TRANSMITIR LA LUZ DE EXCITACION RECIBIDA DENTRO DEL MEDIO DE FLUIDO A TRAVES DE LA CARA DETECTORA, PARA RECIBIR A TRAVES DE LA CARA DETECTORA, LA FLUORESCENCIA EMITIDA POR LOS FLUOROFOROS EXCITADOS EN EL MEDIO DE FLUIDO, Y PARA TRANSMITIR AL MENOS PARTE DE LA FLUORESCENCIA RECIBIDA AL DETECTOR DE LUZ, ESTANDO TANTO EL EMISOR DE LUZ COMO EL DETECTOR POSICIONADOS EN UNA DISTANCIA DESDE LA CARA DETECTORA, Y ESTANDO EL POSICIONADO RELATIVO DEL MISOR DE LUZ, EL DETECTOR OPTICO, Y LA CARA DETECTORA DE MODO QUE EL DETECTOR ES CAPAZ DE RECIBIR LUZ TRANSMITIDA DESDE AL MENOS UNA PARTE DE ESTA PARTE DE LA CARA DETECTORA QUE RECIBE LUZ DESDE EL EMISOR DE LUZ. EL APARATO ES ESPECIALMENTE APROPIADO PARA SU FUNCIONAMIENTO EN MEDIOS TURBIOS O ALTAMENTE TURBIOS COMO UN DEPOSITO DE FERMENTACION O UN AGUA RESIDUAL EN UNA PLANTA PURIFICADORA DE AGUA RESIDUAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK92669A DK66992D0 (da) | 1992-05-21 | 1992-05-21 | Sensor |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2109501T3 true ES2109501T3 (es) | 1998-01-16 |
Family
ID=8096184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93912658T Expired - Lifetime ES2109501T3 (es) | 1992-05-21 | 1993-05-19 | Aparato y metodo para inducir y detectar fluorescencia. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5557415A (es) |
EP (1) | EP0641431B1 (es) |
JP (1) | JPH08504033A (es) |
AT (1) | ATE157771T1 (es) |
CA (1) | CA2136209A1 (es) |
DE (1) | DE69313633T2 (es) |
DK (2) | DK66992D0 (es) |
ES (1) | ES2109501T3 (es) |
NO (1) | NO944427L (es) |
WO (1) | WO1993023738A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5422726A (en) * | 1993-02-16 | 1995-06-06 | Tyler; Jonathan M. | Solid state spectrofluorimeter and method of using the same |
US5401412A (en) * | 1993-07-20 | 1995-03-28 | Biochem Technology, Inc. | Method and apparatus for monitoring biological activity in wastewater and controlling the treatment thereof |
US5552319A (en) * | 1993-07-20 | 1996-09-03 | Biochem Technology, Inc. | Apparatus and method for monitoring and controlling biological activity in wastewater and controlling the treatment thereof |
US5466604A (en) * | 1994-03-08 | 1995-11-14 | Biochem Technology, Inc. | Apparatus for monitoring biological activity in wastewater and controlling the treatment thereof |
US5742064A (en) * | 1996-04-24 | 1998-04-21 | Infante; David A. | System for detecting impurities contained in a flowing petroleum product |
US5781284A (en) * | 1996-04-24 | 1998-07-14 | Infante; David A. | System for detecting impurities contained in a fluid medium |
US6914250B2 (en) | 1997-03-07 | 2005-07-05 | Clare Chemical Research, Inc. | Fluorometric detection using visible light |
US6211524B1 (en) * | 1997-04-18 | 2001-04-03 | The United States Of America As Represented By The United States Department Of Energy | Enhanced radiation detectors using luminescent materials |
WO1998058252A1 (en) * | 1997-06-16 | 1998-12-23 | Delta Lys & Optik | An apparatus for measuring the fluorescence in a medium or a substance |
US6055451A (en) | 1997-12-12 | 2000-04-25 | Spectrx, Inc. | Apparatus and method for determining tissue characteristics |
US6075609A (en) * | 1998-03-26 | 2000-06-13 | Antek Industrial Instruments, Inc. | Apparatus and methods for improving fluorescence detectors |
US6140653A (en) * | 1998-03-27 | 2000-10-31 | Vysis, Inc. | Large-field fluorescence imaging apparatus |
US6106718A (en) * | 1998-07-01 | 2000-08-22 | Biochem Technology, Inc. | Enhanced denitrification process by monitoring and controlling carbonaceous nutrient addition |
ATE266856T1 (de) * | 1999-02-26 | 2004-05-15 | Packard Instrument Co Inc | Lichterzeugung, lichtmessung und bestimmung der menge von substanzen in vertiefungen von mikroplatten |
US6538735B1 (en) | 2000-02-25 | 2003-03-25 | Packard Instrument Company | Method and apparatus for producing and measuring light and for determining the amounts of analytes in microplate wells |
EP1290428A1 (en) * | 2000-06-02 | 2003-03-12 | Medicometrics APS | Method and system for classifying a biological sample |
KR20020022876A (ko) * | 2000-09-21 | 2002-03-28 | 박호군 | 고효율 광섬유 프로브를 이용한 수질오염 측정장치 |
US6879398B2 (en) | 2002-05-22 | 2005-04-12 | Lockheed Martin Corporation | Distributed contaminant optical monitoring system |
US20040259270A1 (en) * | 2003-06-19 | 2004-12-23 | Wolf David E. | System, device and method for exciting a sensor and detecting analyte |
US20050008253A1 (en) * | 2003-07-10 | 2005-01-13 | Joseph Rozgonyi | Method and apparatus for eliminating irrelevant luminescent signals |
US8202479B1 (en) * | 2004-11-09 | 2012-06-19 | Applied Biosystems, Llc | Light collection system |
JP2008541139A (ja) * | 2005-05-04 | 2008-11-20 | スリーエム イノベイティブ プロパティズ カンパニー | 蛍光検出で使用されるパルス光源用のシステムおよび方法 |
US20110133099A1 (en) * | 2008-07-30 | 2011-06-09 | Horiba Advanced Techno, Co., Ltd. | Silicon concentration measuring instrument |
EP2333515A1 (de) * | 2009-12-11 | 2011-06-15 | Bayer Technology Services GmbH | Mittel zur Detektion von lumineszierenden und/oder lichtstreuenden Partikeln in strömenden Flüssigkeiten |
DE102010015083B4 (de) * | 2010-04-15 | 2012-04-12 | Eads Deutschland Gmbh | Sensor und Verfahren zur Online-Überwachung der Säurezahl eines Hydraulikfluids in einem Hydrauliksystem in einem Luftfahrzeug |
CN103063645B (zh) * | 2013-01-04 | 2017-12-05 | 南开大学 | 基于新型微结构光纤的高效荧光检测 |
US20160356719A1 (en) * | 2013-09-13 | 2016-12-08 | Mitsubishi Rayon Co., Ltd. | Image reading method |
DE102016109819B4 (de) * | 2016-05-27 | 2020-07-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung und Verfahren zum Erfassen von Ablagerungen an einer Oberfläche einer Wand eines Behältnisses oder Rohres |
DE102016113042A1 (de) * | 2016-07-15 | 2018-01-18 | B. Braun Melsungen Ag | Durchflussmesszellenvorrichtung zur Messung von Fluidparametern |
US10126244B2 (en) | 2016-11-11 | 2018-11-13 | B&W Tek Llc | Apparatuses and methods for performing spectroscopic analysis of a subject |
US10119916B2 (en) * | 2016-11-11 | 2018-11-06 | B&W Tek Llc | Light delivery and collection device for measuring Raman scattering of a sample |
US10119917B2 (en) | 2016-11-11 | 2018-11-06 | B & W Tek LLC | Apparatus and method for bidirectional Raman spectroscopy |
US10113969B2 (en) | 2016-11-11 | 2018-10-30 | B&W Tek Llc | Methods and devices for measuring Raman scattering of a sample |
Family Cites Families (39)
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DE258471C (es) * | ||||
US2139797A (en) * | 1936-04-25 | 1938-12-13 | Edward W Boerstler | Fluorescence detecting apparatus |
US2971429A (en) * | 1957-02-06 | 1961-02-14 | American Instr Co Inc | Spectro-fluorescence measuring instrument |
US3068739A (en) * | 1958-06-23 | 1962-12-18 | American Optical Corp | Flexible optical probe |
US3510648A (en) * | 1967-04-25 | 1970-05-05 | Honeywell Inc | Apparatus employing ultraviolet radiation for measuring the amount of fluorescent material in a continuously flowing fluid stream |
US3690773A (en) * | 1970-11-19 | 1972-09-12 | Unilex Inc | Dual photoconductive cell photometer |
US3918812A (en) * | 1973-05-07 | 1975-11-11 | Us Energy | Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams |
US3854050A (en) * | 1973-09-11 | 1974-12-10 | Department Of Health Education | High precision fluorometer for measuring enzymatic substrates in tissue |
GB1452945A (en) * | 1973-10-08 | 1976-10-20 | Partech Electronics Ltd | Apparatus for monitoring suspended particles in a liquid |
SE7410610L (sv) * | 1974-08-21 | 1976-02-23 | Lkb Produkter Ab | Optiskt system i en odlingstank. |
US3941477A (en) * | 1974-10-17 | 1976-03-02 | Deutsche Forschungs-Und Versuchsanstalt Fur Luft-Und Raumfahrt E.V. | Measuring device for the measurement of fluid flow rates |
US4031399A (en) * | 1975-02-24 | 1977-06-21 | Beckman Instruments, Inc. | Fluorometer |
US4036946A (en) * | 1975-10-20 | 1977-07-19 | Marcos Kleinerman | Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances |
US4055768A (en) * | 1976-09-07 | 1977-10-25 | Bromberg Nathan S | Light measuring apparatus |
DE2925855A1 (de) * | 1978-06-30 | 1980-01-17 | Chelsea Instr Ltd | Unterwasser- oder untertauchbarer fluoreszenzmesser und verfahren zur benutzung eines solchen instruments |
US4197458A (en) * | 1978-07-31 | 1980-04-08 | Benno Perren | Electro-optical apparatus for the detection of the presence of liquid |
DE2842343A1 (de) * | 1978-09-28 | 1980-04-10 | Siemens Ag | Fluoreszenz-messanordnung |
US4221485A (en) * | 1979-06-04 | 1980-09-09 | Honeywell Inc. | Optical smoke detector |
US4295199A (en) * | 1979-10-22 | 1981-10-13 | Bio-Rad Laboratories, Inc. | Automatic fluorometer and data processor for performing fluorescent immunoassays |
DE3020168A1 (de) * | 1980-05-28 | 1981-12-03 | Eur-Control Regeltechnik GmbH, 4630 Bochum | Vorrichtung zum messen der konzentration von in fluessigkeiten enthaltenem oel |
EP0047094B1 (en) * | 1980-08-21 | 1986-11-20 | Oriel Scientific Limited | Analytical optical instruments |
US4447546A (en) * | 1982-08-23 | 1984-05-08 | Myron J. Block | Fluorescent immunoassay employing optical fiber in capillary tube |
SE435761B (sv) * | 1983-03-24 | 1984-10-15 | Asea Ab | Fiberoptiskt luminiscensmetdon |
US4577110A (en) * | 1983-04-11 | 1986-03-18 | Biochem Sensors, Inc. | Optical apparatus and method for measuring the characteristics of materials by their fluorescence |
FI831936A0 (fi) * | 1983-05-30 | 1983-05-30 | Labsystems Oy | Anordning foer maetning av fluorescens, turbiditet, luminescens eller absorption |
US4560881A (en) * | 1984-03-13 | 1985-12-24 | Syntex (U.S.A.) Inc. | Method and apparatus for enhanced detection of electromagnetic signals |
FI843409A0 (fi) * | 1984-08-29 | 1984-08-29 | Labsystems Oy | Fluorometer. |
CH665033A5 (fr) * | 1985-07-01 | 1988-04-15 | Prutec Ltd | Guide d'onde utilisable comme sonde optique dans l'analyse spectroscopique a reflexion interne. |
US4929561A (en) * | 1985-08-08 | 1990-05-29 | Regents Of The University Of California | Absorption-emission optrode and methods of use thereof |
US4927222A (en) * | 1986-06-16 | 1990-05-22 | Shiley Incorporated | Dual optical fiber device |
CA1332205C (en) * | 1988-03-15 | 1994-10-04 | James W. Snow | Fibre optic sensors for the continuous measurement of liquid level and other parameters |
US4934811A (en) * | 1988-04-01 | 1990-06-19 | Syntex (U.S.A.) Inc. | Apparatus and method for detection of fluorescence or light scatter |
US5221958A (en) * | 1989-05-01 | 1993-06-22 | Wolfram Bohnenkamp | Reflection fluorometer |
US5018866A (en) * | 1989-09-12 | 1991-05-28 | Packard Instrument Company | Method and apparatus for performing high sensitivity fluorescence measurements |
FR2653559B1 (fr) * | 1989-10-20 | 1993-07-16 | Commissariat Energie Atomique | Dispositif pour la determination, par fluorescence moleculaire, de la concentration d'un composant a surveiller dans un melange gazeux en circulation. |
DE3938142A1 (de) * | 1989-11-16 | 1991-05-29 | Mak Maschinenbau Krupp | Verfahren und vorrichtung zur qualitativen und quantitativen bestimmung von inhaltsstoffen |
US5059790A (en) * | 1990-03-30 | 1991-10-22 | Fiberchem, Inc. | Reservoir fiber optic chemical sensors |
US5155046A (en) * | 1990-08-10 | 1992-10-13 | Puritan-Bennett Corporation | System and method for measuring oxygen in the presence of halothane |
US5156976A (en) * | 1991-06-07 | 1992-10-20 | Ciba Corning Diagnostics Corp. | Evanescent wave sensor shell and apparatus |
-
1992
- 1992-05-21 DK DK92669A patent/DK66992D0/da not_active Application Discontinuation
-
1993
- 1993-05-19 WO PCT/DK1993/000171 patent/WO1993023738A1/en active IP Right Grant
- 1993-05-19 EP EP93912658A patent/EP0641431B1/en not_active Expired - Lifetime
- 1993-05-19 JP JP5519797A patent/JPH08504033A/ja active Pending
- 1993-05-19 ES ES93912658T patent/ES2109501T3/es not_active Expired - Lifetime
- 1993-05-19 DE DE69313633T patent/DE69313633T2/de not_active Expired - Lifetime
- 1993-05-19 DK DK93912658.7T patent/DK0641431T3/da active
- 1993-05-19 US US08/343,511 patent/US5557415A/en not_active Expired - Lifetime
- 1993-05-19 CA CA002136209A patent/CA2136209A1/en not_active Abandoned
- 1993-05-19 AT AT93912658T patent/ATE157771T1/de active
-
1994
- 1994-11-18 NO NO944427A patent/NO944427L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0641431B1 (en) | 1997-09-03 |
JPH08504033A (ja) | 1996-04-30 |
DK0641431T3 (da) | 1998-03-30 |
EP0641431A1 (en) | 1995-03-08 |
NO944427D0 (no) | 1994-11-18 |
NO944427L (no) | 1994-11-18 |
CA2136209A1 (en) | 1993-11-25 |
DK66992D0 (da) | 1992-05-21 |
DE69313633D1 (de) | 1997-10-09 |
WO1993023738A1 (en) | 1993-11-25 |
DE69313633T2 (de) | 1998-04-02 |
ATE157771T1 (de) | 1997-09-15 |
US5557415A (en) | 1996-09-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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