ES2106111T3 - Procedimiento para preparar derivados de la 1,2,3,4-tetrahidro-3-isoquinolina. - Google Patents
Procedimiento para preparar derivados de la 1,2,3,4-tetrahidro-3-isoquinolina.Info
- Publication number
- ES2106111T3 ES2106111T3 ES92115206T ES92115206T ES2106111T3 ES 2106111 T3 ES2106111 T3 ES 2106111T3 ES 92115206 T ES92115206 T ES 92115206T ES 92115206 T ES92115206 T ES 92115206T ES 2106111 T3 ES2106111 T3 ES 2106111T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkoxy
- formula
- image
- alkoxy
- isoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LOS DERIVADOS DE LA 1,2,3,4 LCOXI BAJO O FENIL EDE ESTAR SUBSTITUIDO SIMPLE O MULTIPLEMENTE POR ALQUILO BAJO O ALCOXI BAJO, PUEDEN SER PRODUCIDOS CICLANDO UN DERIVADO FENETILAMINO DE LA FORMULA EN DONDE Z EQUIVALE A BENCILOXICARBONILO Y R" A HIDROXI, ALQUILAMINO BAJO, ALCOXI BAJO O FENIL O MULTIPLEMENTE POR UN ALQUILO BAJO O UN ALCOXI BAJO, EN PRESENCIA DE ACIDO SULFURICO EN ACIDO ACETICO O FORMALDEHIDO EN EL CORRESPONDIENTE DERIVADO DE LA TETRAHIDROISOQUINOLINA DE LA FORMULA Y DESDOBLANDO EL GRUPO Z EN EL COMPUESTO OBTENIDO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH275291 | 1991-09-18 | ||
CH213092 | 1992-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2106111T3 true ES2106111T3 (es) | 1997-11-01 |
Family
ID=25689595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92115206T Expired - Lifetime ES2106111T3 (es) | 1991-09-18 | 1992-09-05 | Procedimiento para preparar derivados de la 1,2,3,4-tetrahidro-3-isoquinolina. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5256783A (es) |
EP (1) | EP0533000B1 (es) |
JP (1) | JPH0772179B2 (es) |
AT (1) | ATE154930T1 (es) |
DE (1) | DE59208658D1 (es) |
DK (1) | DK0533000T3 (es) |
ES (1) | ES2106111T3 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0578163A1 (de) * | 1992-07-09 | 1994-01-12 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von D- bzw.L-bzw. D,L-1,2,3,4-Tetrahydroisochinolin-3-Carbonsäure |
US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
US5846993A (en) * | 1992-12-22 | 1998-12-08 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
US5514801A (en) * | 1992-12-29 | 1996-05-07 | Monsanto Company | Cyclic sulfone containing retroviral protease inhibitors |
US5527829A (en) * | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
ES2135171T5 (es) * | 1995-06-30 | 2006-03-16 | Ajinomoto Co., Inc. | Procedimiento para producir amidas opticamente activas. |
WO1997017050A2 (en) * | 1995-11-09 | 1997-05-15 | Monsanto Company | An improved method for preparation of substituted tetrahydroisoquinolines |
US5587481A (en) * | 1996-02-20 | 1996-12-24 | The Monsanto Company | Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide |
IT1283640B1 (it) * | 1996-07-29 | 1998-04-23 | Archimica Spa | Procedimento per la preparazione di un acido tetraidrochinolincarbossilico otticamente puro |
US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
IT1301825B1 (it) * | 1998-06-26 | 2000-07-07 | Archimica Spa | Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide. |
EP1095022A1 (en) | 1998-07-08 | 2001-05-02 | G.D. Searle & Co. | Retroviral protease inhibitors |
KR100277723B1 (ko) * | 1998-12-14 | 2001-01-15 | 남창우 | 광학적으로 순수한 데카하이드로이소퀴놀린카르복사미드의 연속제조공정 |
CZ299699B6 (cs) * | 1998-12-14 | 2008-10-22 | Sk Corporation | Zpusob výroby [3S-(3alfa, 4alfabeta, 8alfabeta)]-N-terc-butyl-dekahydro-3-izochinolinkarboxamidu s vysokým optickým výtežkem |
IT1318986B1 (it) * | 2000-10-09 | 2003-09-19 | Archimica S P A Ora Clariant L | Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide. |
CN1300115C (zh) * | 2004-03-26 | 2007-02-14 | 厦门大学 | 一种合成1,2,3,4-四氢异喹啉衍生物的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3836536A (en) * | 1972-06-08 | 1974-09-17 | Warner Lambert Co | 1,2,3,4-tetrahydro-3-aminomethyliso-quinolines |
US3906009A (en) * | 1973-07-16 | 1975-09-16 | Phillips Petroleum Co | Oxidative dehydrogenation of alkenes of alkadienes to furan compounds using certain V-P catalyts |
US4912221A (en) * | 1988-10-27 | 1990-03-27 | Occidental Chemical Corporation | Chiral 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and precursors and preparation thereof |
-
1992
- 1992-09-02 US US07/938,750 patent/US5256783A/en not_active Expired - Lifetime
- 1992-09-05 EP EP92115206A patent/EP0533000B1/de not_active Expired - Lifetime
- 1992-09-05 DE DE59208658T patent/DE59208658D1/de not_active Expired - Lifetime
- 1992-09-05 DK DK92115206.2T patent/DK0533000T3/da active
- 1992-09-05 AT AT92115206T patent/ATE154930T1/de active
- 1992-09-05 ES ES92115206T patent/ES2106111T3/es not_active Expired - Lifetime
- 1992-09-16 JP JP4270769A patent/JPH0772179B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0533000A1 (de) | 1993-03-24 |
JPH05213887A (ja) | 1993-08-24 |
EP0533000B1 (de) | 1997-07-02 |
DE59208658D1 (de) | 1997-08-07 |
DK0533000T3 (da) | 1997-10-13 |
US5256783A (en) | 1993-10-26 |
ATE154930T1 (de) | 1997-07-15 |
JPH0772179B2 (ja) | 1995-08-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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