ES2105972A1 - A process for obtaining changes in biological responses with haematopoietic function recovery activity from either of two N2 fixing bacterial strains Azotobacter chroococcum and Azotobacter vinilandii - Google Patents
A process for obtaining changes in biological responses with haematopoietic function recovery activity from either of two N2 fixing bacterial strains Azotobacter chroococcum and Azotobacter vinilandiiInfo
- Publication number
- ES2105972A1 ES2105972A1 ES09501587A ES9501587A ES2105972A1 ES 2105972 A1 ES2105972 A1 ES 2105972A1 ES 09501587 A ES09501587 A ES 09501587A ES 9501587 A ES9501587 A ES 9501587A ES 2105972 A1 ES2105972 A1 ES 2105972A1
- Authority
- ES
- Spain
- Prior art keywords
- azotobacter
- obtaining
- vinilandii
- haematopoietic
- biological responses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
A process for obtaining changes in biological responses with haematopoietic function recovery activity from either of two N2 fixing bacterial strains Azotobacter chroococcum and Azotobacter vinilandii This invention describes the process for obtaining two preparations obtained from pure cultures of selected strains of Azotobacter chroococcum and Azotobacter vinilandii respectively, which have properties which stimulate haematopoietic function. This process comprises growing the corresponding bacterial culture, obtaining an F1 fraction or cell fraction obtained in the supernatant from the culture cells through an acid-base shock treatment, the obtaining of an F2 fraction or exocellular fraction obtained by treatment of the culture supernatant with metal iron, freeze-drying of the two concentration fractions defined by each of these. The preparation so obtained is active in stimulating the activity of the haematopoietic system, and is active when administered orally. It has application for human and veterinary use.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501587A ES2105972B1 (en) | 1995-08-03 | 1995-08-03 | A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501587A ES2105972B1 (en) | 1995-08-03 | 1995-08-03 | A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2105972A1 true ES2105972A1 (en) | 1997-10-16 |
ES2105972B1 ES2105972B1 (en) | 1998-06-01 |
Family
ID=8291292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9501587A Expired - Fee Related ES2105972B1 (en) | 1995-08-03 | 1995-08-03 | A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2105972B1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0276778A2 (en) * | 1987-01-27 | 1988-08-03 | The Du Pont Merck Pharmaceutical Company | High level expression in E. coli of soluble mature hIL-1beta and derivatives with altered biological activity |
WO1988005786A1 (en) * | 1987-02-06 | 1988-08-11 | Genetics Institute, Inc. | Colony stimulating factors having reduced levels of carbohydrate |
-
1995
- 1995-08-03 ES ES9501587A patent/ES2105972B1/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0276778A2 (en) * | 1987-01-27 | 1988-08-03 | The Du Pont Merck Pharmaceutical Company | High level expression in E. coli of soluble mature hIL-1beta and derivatives with altered biological activity |
WO1988005786A1 (en) * | 1987-02-06 | 1988-08-11 | Genetics Institute, Inc. | Colony stimulating factors having reduced levels of carbohydrate |
Also Published As
Publication number | Publication date |
---|---|
ES2105972B1 (en) | 1998-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19971016 Kind code of ref document: A1 Effective date: 19971016 |
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FD1A | Patent lapsed |
Effective date: 20050804 |