ES2105972B1 - A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER. - Google Patents

A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER.

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Publication number
ES2105972B1
ES2105972B1 ES9501587A ES9501587A ES2105972B1 ES 2105972 B1 ES2105972 B1 ES 2105972B1 ES 9501587 A ES9501587 A ES 9501587A ES 9501587 A ES9501587 A ES 9501587A ES 2105972 B1 ES2105972 B1 ES 2105972B1
Authority
ES
Spain
Prior art keywords
azotobacter
obtaining
procedure
hematopoyetic
function
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9501587A
Other languages
Spanish (es)
Other versions
ES2105972A1 (en
Inventor
De Castro Luis Cifuentes
Ranieri Juan Pablo Pivel
Gomez-Pamo Antonio Guerrero
Fernandez Gabriel Maganto
Roncero Jose Antonio Bueren
Amurrio Guillermo Guenechea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industrial Farmaceutica Cantabria SA
Original Assignee
Industrial Farmaceutica Cantabria SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industrial Farmaceutica Cantabria SA filed Critical Industrial Farmaceutica Cantabria SA
Priority to ES9501587A priority Critical patent/ES2105972B1/en
Publication of ES2105972A1 publication Critical patent/ES2105972A1/en
Application granted granted Critical
Publication of ES2105972B1 publication Critical patent/ES2105972B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN PROCEDIMIENTO PARA LA OBTENCION DE MODIFICADORES DE LAS RESPUESTAS BIOLOGICAS CON ACTIVIDAD RECUPERADORA DE LA FUNCION HEMATOPOYETICA A PARTIR, IGUAL E INDISTINTAMENTE, DE DOS CEPAS BACTERIANAS FIJADORAS DE N2 AZOTOBACTER CHROOCOCCUM Y AZOTOBACTER VINELANDII. LA PRESENTE INVENCION DESCRIBE EL PROCEDIMIENTO DE OBTENCION DE DOS PREPARACIONES OBTENIDAS A PARTIR DE CULTIVOS PUROS DE CEPAS SELECCIONADAS DE AZOTOBACTER CHROOCOCCUM Y AZOTOBACTER VINELANDII RESPECTIVAMENTE Y CON PROPIEDADES ESTIMULADORAS DE LA FUNCION HEMATOPOYETICA. DICHO PROCEDIMIENTO CONSISTE EN EL CRECIMIENTO DEL CORRESPONDIENTE CULTIVO BACTERIANO, LA OBTENCION DE UNA FRACCION F1 O FRACCION CELULAR OBTENIDO EN EL SOBRENADANTE DE LAS CELULAS DEL CULTIVO TRAS UN TRATAMIENTO DE CHOQUE ACIDO-BASICO A LAS MISMAS, LA OBTENCION DE UNA FRACCION F2 O FRACCION EXOCELULAR OBTENIDA POR TRATAMIENTO CON HIERRO METALICO DEL SOBRENADANTE DE CULTIVO, LA LIOFILIZACION DE AMBAS FRACCIONES DE CONCENTRACION DEFINIDA DE CADA UNA DE ELLAS. EL PREPARADO ASI OBTENIDO ESTA DOTADO DE ACTIVIDAD ESTIMULADORA DE LA ACTIVIDAD DEL SISTEMA HEMATOPOYETICO, Y ES ACTIVO POR VIA ORAL. TIENE APLICACION PARA USO HUMANO Y VETERINARIO.A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER. THE PRESENT INVENTION DESCRIBES THE PROCEDURE FOR OBTAINING TWO PREPARATIONS OBTAINED FROM PURE CROPS OF SELECTED STRAINS OF AZOTOBACTER CHROOCOCCUM AND AZOTOBACTER VINELANDII RESPECTIVELY AND WITH STIMULATING PROPERTIES OF HEMAT FUNCTION. SUCH PROCEDURE CONSISTS IN THE GROWTH OF THE CORRESPONDING BACTERIAL CULTIVATION, THE OBTAINING OF AN F1 FRACTION OR CELLULAR FRACTION OBTAINED IN THE OVERLAPPING OF THE CELL CELLS AFTER A TREATMENT OF AN ACID-BASIC SHOCK, THROUGH THE SAME FRACTION, OR OBTAINED BY METALLIC IRON TREATMENT OF THE CROP OVERLAB, THE LYOPHILIZATION OF BOTH FRACTIONS OF DEFINED CONCENTRATION OF EACH ONE OF THEM. THE PREPARED SO OBTAINED IS EQUIPPED WITH STIMULATING ACTIVITY OF THE ACTIVITY OF THE HEMATOPOYETIC SYSTEM, AND IT IS ACTIVE BY ORAL WAY. IT HAS APPLICATION FOR HUMAN AND VETERINARY USE.

ES9501587A 1995-08-03 1995-08-03 A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER. Expired - Fee Related ES2105972B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9501587A ES2105972B1 (en) 1995-08-03 1995-08-03 A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9501587A ES2105972B1 (en) 1995-08-03 1995-08-03 A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER.

Publications (2)

Publication Number Publication Date
ES2105972A1 ES2105972A1 (en) 1997-10-16
ES2105972B1 true ES2105972B1 (en) 1998-06-01

Family

ID=8291292

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9501587A Expired - Fee Related ES2105972B1 (en) 1995-08-03 1995-08-03 A PROCEDURE FOR THE OBTAINING OF BIOLOGICAL RESPONSE MODIFIERS WITH RECOVERY ACTIVITY OF THE HEMATOPOYETIC FUNCTION FROM, EQUALLY AND INDISTINCATELY, TWO BACTERIAL STRAINS FIXING N2 AZOTOBACTER CHROOCOCCUM AND VINEL AZOTOBACTER.

Country Status (1)

Country Link
ES (1) ES2105972B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
AU1369088A (en) * 1987-02-06 1988-08-24 Genetics Institute Inc. Colony stimulating factors having reduced levels of carbohydrate

Also Published As

Publication number Publication date
ES2105972A1 (en) 1997-10-16

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