ES2105937A1 - Procedimiento para la preparacion del acido 14,15-dihidro-14b-hidroxi-(3*, 16*)-eburnamenina-14-carboxilico. - Google Patents

Procedimiento para la preparacion del acido 14,15-dihidro-14b-hidroxi-(3*, 16*)-eburnamenina-14-carboxilico.

Info

Publication number
ES2105937A1
ES2105937A1 ES09401517A ES9401517A ES2105937A1 ES 2105937 A1 ES2105937 A1 ES 2105937A1 ES 09401517 A ES09401517 A ES 09401517A ES 9401517 A ES9401517 A ES 9401517A ES 2105937 A1 ES2105937 A1 ES 2105937A1
Authority
ES
Spain
Prior art keywords
alpha
eburnamenine
dihydro
hydroxy
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09401517A
Other languages
English (en)
Other versions
ES2105937B1 (es
Inventor
Mondelo Fernando Calvo
Ferrero Maria Teresa Manresa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covex SA
Original Assignee
Covex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covex SA filed Critical Covex SA
Priority to ES9401517A priority Critical patent/ES2105937B1/es
Priority to CN95104860A priority patent/CN1045295C/zh
Publication of ES2105937A1 publication Critical patent/ES2105937A1/es
Application granted granted Critical
Publication of ES2105937B1 publication Critical patent/ES2105937B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DEL ACIDO 14, 15-DIHIDRO -14BE- HIDROXI- (3AL, 16AL)- EBURNAMENINA- 14- CARBOXILICO. COMPRENDE HACER REACCIONAR EL 14, 15-DIHIDRO -14BE- HIDROXI- (3AL, 16AL)- EBURNAMENINA- 14- METANOL (II) CON PEROXIDO DE NIQUEL EN MEDIO BASICO ACUOSO O METANOLICO Y A LA TEMPERATURA DE EBULLICION DEL DISOLVENTE, PARA PRODUCIR EL 14, 15-DIHIDRO -14BE- HIDROXI- (3AL, 16AL)- EBURNAMENINA-14- CARBOXILICO (I). EL COMPUESTO (I) TIENE APLICACION POR SUS PROPIEDADES COMO VASODILATADOR Y OXIGENADOR CEREBRAL. ASIMISMO, ES UN INTERMEDIO UTIL EN LA SINTESIS DE OTRO IMPORTANTE OXIGENADOR CEREBRAL, LA VINPOCETINA.
ES9401517A 1994-07-12 1994-07-12 Procedimiento para la preparacion del acido 14,15-dihidro-14b-hidroxi-(3*, 16*)-eburnamenina-14-carboxilico. Expired - Lifetime ES2105937B1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES9401517A ES2105937B1 (es) 1994-07-12 1994-07-12 Procedimiento para la preparacion del acido 14,15-dihidro-14b-hidroxi-(3*, 16*)-eburnamenina-14-carboxilico.
CN95104860A CN1045295C (zh) 1994-07-12 1995-05-16 14,15－二氢－14β－羟基－(3α,16α)象牙烯宁－14－羧酸的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9401517A ES2105937B1 (es) 1994-07-12 1994-07-12 Procedimiento para la preparacion del acido 14,15-dihidro-14b-hidroxi-(3*, 16*)-eburnamenina-14-carboxilico.

Publications (2)

Publication Number Publication Date
ES2105937A1 true ES2105937A1 (es) 1997-10-16
ES2105937B1 ES2105937B1 (es) 1998-07-01

Family

ID=8286871

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9401517A Expired - Lifetime ES2105937B1 (es) 1994-07-12 1994-07-12 Procedimiento para la preparacion del acido 14,15-dihidro-14b-hidroxi-(3*, 16*)-eburnamenina-14-carboxilico.

Country Status (2)

Country Link
CN (1) CN1045295C (es)
ES (1) ES2105937B1 (es)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2191890A1 (en) * 1972-07-13 1974-02-08 Synthelabo Ethyl vincaminate and its salts - cerebral oxygenator and vasoregulator, prepd from vincaminic acid and diazoethane
ES8506709A1 (es) * 1984-11-02 1985-08-16 Covex Sa Procedimiento para la preparacion de los compuestos 14, 15-dihidro-14 -14 -hidroxi-14 -14 -metanol-eburnamenina
ES2001320A6 (es) * 1986-11-12 1988-05-01 Covex Sa Procedimiento para la preparacion del acido (3 alfa, 16 alfa)-eburnamenina-14-carboxilico

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2191890A1 (en) * 1972-07-13 1974-02-08 Synthelabo Ethyl vincaminate and its salts - cerebral oxygenator and vasoregulator, prepd from vincaminic acid and diazoethane
ES8506709A1 (es) * 1984-11-02 1985-08-16 Covex Sa Procedimiento para la preparacion de los compuestos 14, 15-dihidro-14 -14 -hidroxi-14 -14 -metanol-eburnamenina
ES2001320A6 (es) * 1986-11-12 1988-05-01 Covex Sa Procedimiento para la preparacion del acido (3 alfa, 16 alfa)-eburnamenina-14-carboxilico

Also Published As

Publication number Publication date
CN1045295C (zh) 1999-09-29
ES2105937B1 (es) 1998-07-01
CN1118348A (zh) 1996-03-13

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